Germ cell tumor causes

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  • Individuals with Differences of Sex Development (DSDs) are predisposed to gonadal germ cell tumor (GCT)
  • Common causes of seminoma may include:[1][2]
  • Cryptorchidism
  • Undescended testis
  • Abdominal testis
  • Trauma
  • Mumps
  • Maternal estrogen exposure
  • Genetic Causes
  • Seminoma is caused by a mutation in the KIT gene.
  • 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases.


References

  1. ↑ Ferguson L, Agoulnik AI (2013). "Testicular cancer and cryptorchidism". Front Endocrinol (Lausanne). 4: 32. doi:10.3389/fendo.2013.00032. PMID 23519268.
  2. ↑ Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH (December 2000). "Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma?". J. Urol. 164 (6): 2143–4. PMID 11061944.
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