Germ cell tumor causes
- Common causes of seminoma may include:[1][2]
- Cryptorchidism
- Undescended testis
- Abdominal testis
- Trauma
- Mumps
- Maternal estrogen exposure
- Genetic Causes
- Seminoma is caused by a mutation in the KIT gene.
- 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases.
- ↑ Ferguson L, Agoulnik AI (2013). "Testicular cancer and cryptorchidism". Front Endocrinol (Lausanne). 4: 32. doi:10.3389/fendo.2013.00032. PMID 23519268.
- ↑ Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH (December 2000). "Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma?". J. Urol. 164 (6): 2143–4. PMID 11061944.