Gentamicin: Difference between revisions

Jump to navigation Jump to search
mNo edit summary
No edit summary
 
(20 intermediate revisions by 3 users not shown)
Line 1: Line 1:
__NOTOC__
{{Details0|Gentamicin (Injection)}}
{{Gentamicin}}
{{Details0|Gentamicin (ophthalmic)}}
{{CMG}}
{{Details0|Gentamicin (topical)}}
 
==Overview==
 
'''Gentamicin''' is an [[aminoglycoside]] [[antibiotic]], and can treat many types of [[bacterium|bacteria]]l infections, particularly [[Gram-negative]] infection. However, gentamicin is not used for ''[[Neisseria gonorrhoeae]]'', ''[[Neisseria meningitidis]]'' or ''[[Legionella pneumophila]]'' infections.
 
It is synthesized by ''[[Micromonospora]]'', a genus of Gram-positive bacteria widely present in the environment (water and soil). Gentamicin is a [[bactericidal]] antibiotic that works by binding the 30S subunit of the bacterial [[ribosome]], interrupting protein synthesis.
 
Like all aminoglycosides, when gentamicin is given orally, it is not systemically active. This is because it is not absorbed to any appreciable extent from the [[small intestine]]. It appears to be completely eliminated unchanged in the urine. Urine must be collected for many days to recover all of a given dose because the drug binds avidly to certain tissues. It is administered [[Intravenous therapy|intravenously]], [[Intramuscular injection|intramuscularly]] or [[topical]]ly to treat infections.
 
''[[Escherichia coli|E. coli]]'' has shown some resistance to gentamicin, despite being Gram-negative.
 
Gentamicin is one of the few heat-stable antibiotics that remain active even after autoclaving, which makes it particularly useful in the preparation of certain microbiological growth media.
 
Treatment of susceptible bacterial infections, normally gram-negative organisms including ''Pseudomonas'', ''Proteus'', ''Serratia'', and Gram-positive ''Staphylococcus''.
 
==Category==
 
Aminoglycoside
 
==US Brand Names==
 
APOGEN<sup>®</sup>, BRISTAGEN<sup>®</sup>, GARAMYCIN<sup>®</sup>, GENOPTIC<sup>®</sup>, GENTACIDIN<sup>®</sup>, GENTAFAIR<sup>®</sup>, GENTAK<sup>®</sup>, GENTAMICIN<sup>®</sup>, GENTAMICIN SULFATE<sup>®</sup>, U-GENCIN<sup>®</sup>
 
==FDA Package Insert==
 
'''  [[Gentamicin description|Description]]'''
'''| [[Gentamicin clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Gentamicin microbiology|Microbiology]]'''
'''| [[Gentamicin indications and usage|Indications and Usage]]'''
'''| [[Gentamicin contraindications|Contraindications]]'''
'''| [[Gentamicin warnings and precautions|Warnings and Precautions]]'''
'''| [[Gentamicin adverse reactions|Adverse Reactions]]'''
'''| [[Gentamicin drug interactions|Drug Interactions]]'''
'''| [[Gentamicin overdosage|Overdosage]]'''
'''| [[Gentamicin clinical studies|Clinical Studies]]'''
'''| [[Gentamicin dosage and administration|Dosage and Administration]]'''
'''| [[Gentamicin how supplied|How Supplied]]'''
'''| [[Gentamicin labels and packages|Labels and Packages]]'''
 
==Mechanism of Action==
 
Gentamicin is a [[bactericidal]] antibiotic that works by irreversibly binding the [[30S]] subunit of the bacterial [[ribosome]], interrupting protein synthesis.  This mechanism of action is similar to other [[aminoglycosides]].
 
==References==
{{Reflist|2}}
 
[[Category:Antibiotics]]
[[Category:Wikinfect]]

Latest revision as of 19:44, 7 May 2015