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| | | {{Details0|Gentamicin (Injection)}} |
| {{SI}} | | {{Details0|Gentamicin (ophthalmic)}} |
| {{CMG}} | | {{Details0|Gentamicin (topical)}} |
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| __NOTOC__
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| {{XXXXX}} | |
| {{CMG}}
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| ==Overview==
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| '''Gentamicin''' is an [[aminoglycoside]] [[antibiotic]], and can treat many types of [[bacterium|bacteria]]l infections, particularly [[Gram-negative]] infection. However, gentamicin is not used for ''[[Neisseria gonorrhoeae]]'', ''[[Neisseria meningitidis]]'' or ''[[Legionella pneumophila]]'' infections.
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| It is synthesized by ''[[Micromonospora]]'', a genus of Gram-positive bacteria widely present in the environment (water and soil). Gentamicin is a [[bactericidal]] antibiotic that works by binding the 30S subunit of the bacterial [[ribosome]], interrupting protein synthesis.
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| Like all aminoglycosides, when gentamicin is given orally, it is not systemically active. This is because it is not absorbed to any appreciable extent from the [[small intestine]]. It appears to be completely eliminated unchanged in the urine. Urine must be collected for many days to recover all of a given dose because the drug binds avidly to certain tissues. It is administered [[Intravenous therapy|intravenously]], [[Intramuscular injection|intramuscularly]] or [[topical]]ly to treat infections.
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| ''[[Escherichia coli|E. coli]]'' has shown some resistance to gentamicin, despite being Gram-negative.
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| Gentamicin is one of the few heat-stable antibiotics that remain active even after autoclaving, which makes it particularly useful in the preparation of certain microbiological growth media.
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| Treatment of susceptible bacterial infections, normally gram-negative organisms including ''Pseudomonas'', ''Proteus'', ''Serratia'', AND Gram-positive ''Staphylococcus'';
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| http://www.merck.com/mmpe/lexicomp/gentamicin.html
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| ==Category==
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| ==US Brand Names==
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| ==FDA Package Insert==
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| ''' [[XXXXX description|Description]]'''
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| '''| [[XXXXX clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[XXXXX microbiology|Microbiology]]'''
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| '''| [[XXXXX indications and usage|Indications and Usage]]'''
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| '''| [[XXXXX contraindications|Contraindications]]'''
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| '''| [[XXXXX warnings and precautions|Warnings and Precautions]]'''
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| '''| [[XXXXX adverse reactions|Adverse Reactions]]'''
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| '''| [[XXXXX drug interactions|Drug Interactions]]'''
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| '''| [[XXXXX overdosage|Overdosage]]'''
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| '''| [[XXXXX clinical studies|Clinical Studies]]'''
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| '''| [[XXXXX dosage and administration|Dosage and Administration]]'''
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| '''| [[XXXXX how supplied|How Supplied]]'''
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| '''| [[XXXXX labels and packages|Labels and Packages]]'''
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| APOGEN, BRISTAGEN, GARAMYCIN, GENOPTIC, GENTACIDIN, GENTAFAIR, GENTAK, GENTAMICIN, GENTAMICIN SULFATE, U-GENCIN
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| ==Mechanism of Action==
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antibiotics]]
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| [[Category:Wikinfect]]
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