View source for Gamma-aminobutyric acid receptor subunit alpha-1

{{Infobox_gene}}
'''Gamma-aminobutyric acid receptor subunit alpha-1''' is a [[protein]] that in humans is encoded by the ''GABRA1'' [[gene]].<ref name="pmid1330891">{{cite journal |vauthors=Johnson KJ, Sander T, Hicks AA, van Marle A, Janz D, Mullan MJ, Riley BP, Darlison MG | title = Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis | journal = Genomics | volume = 14 | issue = 3 | pages = 745–8 |date=Dec 1992 | pmid = 1330891 | pmc =  | doi =  10.1016/S0888-7543(05)80178-8}}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = GABA is the major [[inhibitory neurotransmitter]] in the [[mammalian brain]] where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2554| accessdate = }}</ref>
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The GABRA1 receptor is the specific target of the [[z-drug]] class of [[nonbenzodiazepine]] [[hypnotic]] agents and is responsible for their hypnotic and [[hallucinogen]]ic effects.

==See also==
* [[GABAA receptor|GABA<sub>A</sub> receptor]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal   |vauthors=Schofield PR, Pritchett DB, Sontheimer H, etal |title=Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits. |journal=FEBS Lett. |volume=244 |issue= 2 |pages= 361–4 |year= 1989 |pmid= 2465923 |doi=10.1016/0014-5793(89)80563-0  }}
*{{cite journal   |vauthors=Garrett KM, Duman RS, Saito N, etal |title=Isolation of a cDNA clone for the alpha subunit of the human GABA-A receptor. |journal=Biochem. Biophys. Res. Commun. |volume=156 |issue= 2 |pages= 1039–45 |year= 1988 |pmid= 2847710 |doi=10.1016/S0006-291X(88)80949-5  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal   |vauthors=Kang I, Lindquist DG, Kinane TB, etal |title=Isolation and characterization of the promoter of the human GABAA receptor alpha 1 subunit gene. |journal=J. Neurochem. |volume=62 |issue= 4 |pages= 1643–6 |year= 1994 |pmid= 8133292 |doi= 10.1046/j.1471-4159.1994.62041643.x }}
*{{cite journal  |vauthors=Tögel M, Mossier B, Fuchs K, Sieghart W |title=gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties. |journal=J. Biol. Chem. |volume=269 |issue= 17 |pages= 12993–8 |year= 1994 |pmid= 8175718 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  |vauthors=Huang RQ, Dillon GH |title=Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin. |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 243–55 |year= 1998 |pmid= 9655866 |doi=  }}
*{{cite journal   |vauthors=Serretti A, Macciardi F, Cusin C, etal |title=No interaction of GABA(A) alpha-1 subunit and dopamine receptor D4 exon 3 genes in symptomatology of major psychoses. |journal=Am. J. Med. Genet. |volume=88 |issue= 1 |pages= 44–9 |year= 1999 |pmid= 10050966 |doi=10.1002/(SICI)1096-8628(19990205)88:1<44::AID-AJMG8>3.0.CO;2-Y  }}
*{{cite journal   |vauthors=Bonnert TP, McKernan RM, Farrar S, etal |title=theta, a novel gamma-aminobutyric acid type A receptor subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9891–6 |year= 1999 |pmid= 10449790 |doi=10.1073/pnas.96.17.9891 |pmc=22306}}
*{{cite journal   |vauthors=Serretti A, Lilli R, Lorenzi C, etal |title=Dopamine receptor D2 and D4 genes, GABA(A) alpha-1 subunit genes and response to lithium prophylaxis in mood disorders. |journal=Psychiatry Research |volume=87 |issue= 1 |pages= 7–19 |year= 1999 |pmid= 10512150 |doi=10.1016/S0165-1781(99)00056-6  }}
*{{cite journal   |vauthors=Cossette P, Liu L, Brisebois K, etal |title=Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. |journal=Nat. Genet. |volume=31 |issue= 2 |pages= 184–9 |year= 2002 |pmid= 11992121 |doi= 10.1038/ng885 }}
*{{cite journal  |vauthors=Kumar S, Sieghart W, Morrow AL |title=Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. |journal=J. Neurochem. |volume=82 |issue= 1 |pages= 110–7 |year= 2002 |pmid= 12091471 |doi=10.1046/j.1471-4159.2002.00943.x  }}
*{{cite journal  | author=Trudell J |title=Unique assignment of inter-subunit association in GABA(A) alpha 1 beta 3 gamma 2 receptors determined by molecular modeling. |journal=Biochim. Biophys. Acta |volume=1565 |issue= 1 |pages= 91–6 |year= 2002 |pmid= 12225856 |doi=10.1016/S0005-2736(02)00512-6  }}
*{{cite journal  |vauthors=Sarto I, Wabnegger L, Dögl E, Sieghart W |title=Homologous sites of GABA(A) receptor alpha(1), beta(3) and gamma(2) subunits are important for assembly. |journal=Neuropharmacology |volume=43 |issue= 4 |pages= 482–91 |year= 2002 |pmid= 12367595 |doi=10.1016/S0028-3908(02)00160-0  }}
*{{cite journal  |vauthors=Jenkins A, Andreasen A, Trudell JR, Harrison NL |title=Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. |journal=Neuropharmacology |volume=43 |issue= 4 |pages= 669–78 |year= 2002 |pmid= 12367612 |doi=10.1016/S0028-3908(02)00175-2  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
*{{cite journal   |vauthors=Kash TL, Jenkins A, Kelley JC, etal |title=Coupling of agonist binding to channel gating in the GABA(A) receptor. |journal=Nature |volume=421 |issue= 6920 |pages= 272–5 |year= 2003 |pmid= 12529644 |doi= 10.1038/nature01280 }}
*{{cite journal   |vauthors=Lin SK, Chen CK, Ball D, etal |title=Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder. |journal=Pharmacogenomics J. |volume=3 |issue= 6 |pages= 349–55 |year= 2004 |pmid= 14569258 |doi= 10.1038/sj.tpj.6500203 }}
*{{cite journal  |vauthors=Mercik K, Pytel M, Mozrzymas JW |title=Recombinant alpha 1 beta 2 gamma 2 GABA(A) receptors expressed in HEK293 and in QT6 cells show different kinetics. |journal=Neurosci. Lett. |volume=352 |issue= 3 |pages= 195–8 |year= 2004 |pmid= 14625018 |doi=10.1016/j.neulet.2003.08.060  }}
}}
{{refend}}

{{NLM content}}
{{Ligand-gated ion channels}}
{{GABAergics}}

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[[Category:Ion channels]]


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