Gallamine: Difference between revisions

Gallamine
	File:Gallamine triethiodide.svg
Clinical data
Trade names	Flaxedil
AHFS/Drugs.com	International Drug Names
ATC code	M03AC02 (WHO) ;
Identifiers
	IUPAC name 2,2’,2’’-[benzene-1,2,3-triyltris(oxy)]tris(N,N,N-triethylethanaminium) triiodide;
CAS Number	65-29-2 ;
PubChem CID	6172;
IUPHAR/BPS	356;
DrugBank	DB00483 ;
ChemSpider	5937 ;
UNII	Q3254X40X2;
KEGG	D02292 ;
ChEBI	CHEBI:503442 ;
ChEMBL	ChEMBL1200993 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C30H60N3O3+3 · 3 I− (gallamine triethiodide); C24H45N3O3 (gallamine)
Molar mass	891.529 g/mol (gallamine triethiodide); 423.633 g/mol; (gallamine)
3D model (JSmol)	Interactive image;
	SMILES [I-].[I-].[I-].O(c1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)CC[N+](CC)(CC)CC;
	InChI InChI=1S/C24H45N3O3/c1-7-25(8-2)16-19-28-22-14-13-15-23(29-20-17-26(9-3)10-4)24(22)30-21-18-27(11-5)12-6/h13-15H,7-12,16-21H2,1-6H3 ; Key:ICLWTJIMXVISSR-UHFFFAOYSA-N ;
(what is this?) (verify)

VisualWikitext

Revision as of 14:23, 10 April 2015

Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant.^[1] It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine.^[2] Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia^[3]^[4] and occasionally hypertension. Very high doses cause histamine release.

Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.^[5]

The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.

References

↑ "Webster's Online Dictionary - Flaxedil". Retrieved 2008-12-15.
↑ "RxMed: Pharmaceutical Information - FLAXEDIL". Retrieved 2008-12-15.
↑ Morgenstern C, Splith G (October 1965). "[Studies on the causes of gallamine tachycardia and its antagonistic modification by beta adrenolytics]". Der Anaesthesist (in German). 14 (10): 298–301. PMID 4380161. |access-date= requires |url= (help)
↑ WALTS LF (1963). "Ventricular tachycardia with gallamine and cyclopropane anesthesia". Anesthesiology. 24: 119. doi:10.1097/00000542-196301000-00024. PMID 13998750. Retrieved 2014-09-20.
↑ Raghavendra T (July 2002). "Neuromuscular blocking drugs: discovery and development". J R Soc Med. 95 (7): 363–7. doi:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515.

[1] "Webster's Online Dictionary - Flaxedil". Retrieved 2008-12-15.

[2] "RxMed: Pharmaceutical Information - FLAXEDIL". Retrieved 2008-12-15.

[pmid4380161-3] Morgenstern C, Splith G (October 1965). "[Studies on the causes of gallamine tachycardia and its antagonistic modification by beta adrenolytics]". Der Anaesthesist (in German). 14 (10): 298–301. PMID 4380161. |access-date= requires |url= (help)

[pmid13998750-4] WALTS LF (1963). "Ventricular tachycardia with gallamine and cyclopropane anesthesia". Anesthesiology. 24: 119. doi:10.1097/00000542-196301000-00024. PMID 13998750. Retrieved 2014-09-20.

[pmid12091515-5] Raghavendra T (July 2002). "Neuromuscular blocking drugs: discovery and development". J R Soc Med. 95 (7): 363–7. doi:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515.

[1]

[2]

[3]

[4]

[5]

@@ Line 52: / Line 52: @@
 | StdInChIKey = ICLWTJIMXVISSR-UHFFFAOYSA-N
 }}
+'''Gallamine triethiodide''' ('''Flaxedil''') is a [[non-depolarising muscle relaxant]].<ref>{{cite web | title=Webster's Online Dictionary - Flaxedil | url=http://www.websters-online-dictionary.org/Fl/Flaxedil.html| accessdate=2008-12-15}}</ref> It acts by combining with the [[cholinergic receptor]] sites in [[muscle]] and competitively blocking the transmitter action of [[acetylcholine]].<ref>{{ cite web | title=RxMed: Pharmaceutical Information - FLAXEDIL | url=http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20F)/FLAXEDIL.html| accessdate=2008-12-15}}</ref> Gallamine triethiodide has a [[parasympatholytic]] effect on the cardiac [[vagus nerve]] which causes [[tachycardia]]<ref name="pmid4380161">{{cite journal |author=Morgenstern C, Splith G |title=[Studies on the causes of gallamine tachycardia and its antagonistic modification by beta adrenolytics] |language=German |journal=Der Anaesthesist |volume=14 |issue=10 |pages=298–301 | date=October  1965 |pmid=4380161 |doi= |url= |accessdate=2014-09-20}}</ref><ref name="pmid13998750">{{cite journal |author=WALTS LF |title=Ventricular tachycardia with gallamine and cyclopropane anesthesia |journal=Anesthesiology |volume=24 |issue= |pages=119 |year=1963 |pmid=13998750 |doi= 10.1097/00000542-196301000-00024|url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0003-3022&volume=24&issue=&spage=119 |accessdate=2014-09-20}}</ref> and occasionally [[hypertension]]. Very high doses cause [[histamine]] release.
+Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.
+It was developed by [[Daniel Bovet]] in 1947.<ref name="pmid12091515">{{cite journal |author=Raghavendra T |title=Neuromuscular blocking drugs: discovery and development |journal=J R Soc Med |volume=95 |issue=7 |pages=363–7 |date=July 2002 |pmid=12091515 |pmc=1279945 |doi= 10.1258/jrsm.95.7.363|url=http://www.jrsm.org/cgi/pmidlookup?view=long&pmid=12091515}}</ref>
+The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.
+[[File:Flaxedil.png|thumb|left|An ampoule of gallamine.]]
+== References ==
+{{Reflist}}

Gallamine: Difference between revisions

Revision as of 14:23, 10 April 2015

References

Navigation menu