GZMK

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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Granzyme K is a protein that in humans is encoded by the GZMK gene.[1][2]

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.[2]

References

  1. Przetak MM, Yoast S, Schmidt BF (Jun 1995). "Cloning of cDNA for human granzyme 3". FEBS Lett. 364 (3): 268–71. doi:10.1016/0014-5793(95)00407-Z. PMID 7758581.
  2. 2.0 2.1 "Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)".

Further reading