GTF2A1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.

Interactions

GTF2A1 has been shown to interact with TATA binding protein and TBPL1.

See also

• Transcription Factor II A

Model organisms

Model organisms have been used in the study of GTF2A1 function. A conditional knockout mouse line called Gtf2a1^{tm1a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

Gtf2a1 knockout mouse phenotype

Characteristic	Phenotype
All data available at.
Insulin	Normal
Homozygous viability at P14	Abnormal
Recessive lethal study	Abnormal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Cytotoxic T Cell Function	Normal
Spleen Immunophenotyping	Normal
Mesenteric Lymph Node Immunophenotyping	Normal
Epidermal Immune Composition	Normal
Influenza Challenge	Normal

Further reading

• Ha I, Lane WS, Reinberg D (Aug 1991). "Cloning of a human gene encoding the general transcription initiation factor IIB". Nature. 352 (6337): 689–95. doi:10.1038/352689a0. PMID 1876184.
• DeJong J, Bernstein R, Roeder RG (Apr 1995). "Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription". Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3313–7. doi:10.1073/pnas.92.8.3313. PMC 42156. PMID 7724559.
• Ozer J, Moore PA, Bolden AH, Lee A, Rosen CA, Lieberman PM (Oct 1994). "Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription". Genes & Development. 8 (19): 2324–35. doi:10.1101/gad.8.19.2324. PMID 7958899.
• Sun X, Ma D, Sheldon M, Yeung K, Reinberg D (Oct 1994). "Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription". Genes & Development. 8 (19): 2336–48. doi:10.1101/gad.8.19.2336. PMID 7958900.
• Ge H, Roeder RG (Jun 1994). "The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein". The Journal of Biological Chemistry. 269 (25): 17136–40. PMID 8006019.
• Ma D, Watanabe H, Mermelstein F, Admon A, Oguri K, Sun X, Wada T, Imai T, Shiroya T, Reinberg D (Nov 1993). "Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription". Genes & Development. 7 (11): 2246–57. doi:10.1101/gad.7.11.2246. PMID 8224850.
• Tang H, Sun X, Reinberg D, Ebright RH (Feb 1996). "Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex". Proceedings of the National Academy of Sciences of the United States of America. 93 (3): 1119–24. doi:10.1073/pnas.93.3.1119. PMC 40041. PMID 8577725.
• Kashanchi F, Khleif SN, Duvall JF, Sadaie MR, Radonovich MF, Cho M, Martin MA, Chen SY, Weinmann R, Brady JN (Aug 1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex". Journal of Virology. 70 (8): 5503–10. PMC 190508. PMID 8764062.
• Zhou Q, Sharp PA (Oct 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. doi:10.1126/science.274.5287.605. PMID 8849451.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Ozer J, Mitsouras K, Zerby D, Carey M, Lieberman PM (Jun 1998). "Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding". The Journal of Biological Chemistry. 273 (23): 14293–300. doi:10.1074/jbc.273.23.14293. PMID 9603936.
• Yokomori K, Verrijzer CP, Tjian R (Jun 1998). "An interplay between TATA box-binding protein and transcription factors IIE and IIA modulates DNA binding and transcription". Proceedings of the National Academy of Sciences of the United States of America. 95 (12): 6722–7. doi:10.1073/pnas.95.12.6722. PMC 22611. PMID 9618479.
• Na SY, Choi HS, Kim JW, Na DS, Lee JW (Nov 1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". The Journal of Biological Chemistry. 273 (47): 30933–8. doi:10.1074/jbc.273.47.30933. PMID 9812988.
• Upadhyaya AB, Lee SH, DeJong J (Jun 1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". The Journal of Biological Chemistry. 274 (25): 18040–8. doi:10.1074/jbc.274.25.18040. PMID 10364255.
• Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (Sep 1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Molecular and Cellular Biology. 19 (9): 6323–32. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.
• Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (Nov 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". The Journal of Biological Chemistry. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
• Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG (Nov 1999). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13720–5. doi:10.1073/pnas.96.24.13720. PMC 24131. PMID 10570139.
• Solow S, Salunek M, Ryan R, Lieberman PM (May 2001). "Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity". The Journal of Biological Chemistry. 276 (19): 15886–92. doi:10.1074/jbc.M009385200. PMID 11278496.
• Xing J, Sheppard HM, Corneillie SI, Liu X (Jun 2001). "p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction". Molecular and Cellular Biology. 21 (11): 3652–61. doi:10.1128/MCB.21.11.3652-3661.2001. PMC 86992. PMID 11340159.