GSTA2

Glutathione S-transferase A2
PDB rendering based on 1ags.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ags​, 1gsd​, 1gse​, 1gsf​, 1guh​, 1k3l​, 1k3o​, 1k3y​, 1pkw​, 1pkz​, 1pl1​, 1pl2​, 1usb​, 1xwg​, 1ydk​
Identifiers
Symbols	GSTA2 ; GST2; GSTA2-2; GTA2; GTH2; MGC10525
External IDs	Template:OMIM5 HomoloGene: 47952
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutathione S-transferase A2, also known as GSTA2, is a human gene.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Further reading

• Röhrdanz E, Nguyen T, Pickett CB (1992). "Isolation and characterization of the human glutathione S-transferase A2 subunit gene". Arch. Biochem. Biophys. 298 (2): 747–52. PMID 1329668.CS1 maint: Multiple names: authors list (link)
• Stenberg G, Björnestedt R, Mannervik B (1992). "Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line". Protein Expr. Purif. 3 (1): 80–4. PMID 1330133.CS1 maint: Multiple names: authors list (link)
• Klöne A, Hussnätter R, Sies H (1992). "Cloning, sequencing and characterization of the human alpha glutathione S-transferase gene corresponding to the cDNA clone pGTH2". Biochem. J. 285 ( Pt 3): 925–8. PMID 1497629.CS1 maint: Multiple names: authors list (link)
• Bogaards JJ, van Ommen B, van Bladeren PJ (1992). "Purification and characterization of eight glutathione S-transferase isoenzymes of hamster. Comparison of subunit composition of enzymes from liver, kidney, testis, pancreas and trachea". Biochem. J. 286 ( Pt 2): 383–8. PMID 1530570.CS1 maint: Multiple names: authors list (link)
• Strange RC, Fryer AA, Matharoo B; et al. (1992). "The human glutathione S-transferases: comparison of isoenzyme expression in normal and astrocytoma brain". Biochim. Biophys. Acta. 1139 (3): 222–8. PMID 1627661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayes JD, Kerr LA, Cronshaw AD (1990). "Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Molecular relationships between the B1 and B2 subunits and other Alpha class glutathione S-transferases". Biochem. J. 264 (2): 437–45. PMID 2604726.CS1 maint: Multiple names: authors list (link)
• Board PG, Webb GC (1987). "Isolation of a cDNA clone and localization of human glutathione S-transferase 2 genes to chromosome band 6p12". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2377–81. PMID 3031680.
• Rhoads DM, Zarlengo RP, Tu CP (1987). "The basic glutathione S-transferases from human livers are products of separate genes". Biochem. Biophys. Res. Commun. 145 (1): 474–81. PMID 3036131.CS1 maint: Multiple names: authors list (link)
• Chow NW, Whang-Peng J, Kao-Shan CS; et al. (1988). "Human glutathione S-transferases. The Ha multigene family encodes products of different but overlapping substrate specificities". J. Biol. Chem. 263 (26): 12797–800. PMID 3138230.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tu CP, Qian B (1988). "Nucleotide sequence of the human liver glutathione S-transferase subunit 1 cDNA". Biochem. Soc. Trans. 15 (4): 734–6. PMID 3678589.
• Tu CP, Qian B (1987). "Human liver glutathione S-transferases: complete primary sequence of an Ha subunit cDNA". Biochem. Biophys. Res. Commun. 141 (1): 229–37. PMID 3800996.
• Satoh K, Kitahara A, Sato K (1985). "Identification of heterogeneous and microheterogeneous subunits of glutathione S-transferase in rat liver cytosol". Arch. Biochem. Biophys. 242 (1): 104–11. PMID 3901925.CS1 maint: Multiple names: authors list (link)
• Zeng K, Rose JP, Chen HC; et al. (1995). "A surface mutant (G82R) of a human alpha-glutathione S-transferase shows decreased thermal stability and a new mode of molecular association in the crystal". Proteins. 20 (3): 259–63. doi:10.1002/prot.340200306. PMID 7892174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anttila S, Hirvonen A, Vainio H; et al. (1994). "Immunohistochemical localization of glutathione S-transferases in human lung". Cancer Res. 53 (23): 5643–8. PMID 8242618.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki T, Johnston PN, Board PG (1994). "Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes". Genomics. 18 (3): 680–6. PMID 8307579.CS1 maint: Multiple names: authors list (link)
• Ahmad H, Singhal SS, Saxena M, Awasthi YC (1993). "Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver". Biochim. Biophys. Acta. 1161 (2–3): 333–6. PMID 8431482.CS1 maint: Multiple names: authors list (link)
• Rowe JD, Nieves E, Listowsky I (1997). "Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera". Biochem. J. 325 ( Pt 2): 481–6. PMID 9230131.CS1 maint: Multiple names: authors list (link)
• Coles BF, Anderson KE, Doerge DR; et al. (2000). "Quantitative analysis of interindividual variation of glutathione S-transferase expression in human pancreas and the ambiguity of correlating genotype with phenotype". Cancer Res. 60 (3): 573–9. PMID 10676639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tetlow N, Liu D, Board P (2001). "Polymorphism of human Alpha class glutathione transferases". Pharmacogenetics. 11 (7): 609–17. PMID 11668220.CS1 maint: Multiple names: authors list (link)
• Coles BF, Morel F, Rauch C; et al. (2002). "Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression". Pharmacogenetics. 11 (8): 663–9. PMID 11692074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)