Gasdermin D is a protein that in humans is encoded by the GSDMD gene.
[1]
Function
Gasdermin D (GSDMD) is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. GSDMD has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.
Recently, it has become appreciated that GSDMD is the effector molecule for the lytic form of cell death called "pyroptosis." [2][3] This process occurs after activation of the inflammasome, a multi-protein complex that recognizes pathogen associated molecular patterns in the cytosol. GSDMD acts by binding to inner membrane lipids, forming pores, and lysing the cells.[4] It has an additional potential role as an antimicrobial by binding to cardiolipin on bacterial membranes. [5]
↑Dixit, Vishva (2015). "Caspase-11 cleaves gasdermin D for non-canonical inflammasome signaling". Nature. 000.
↑Shao, Feng (2015). "Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death". Nature. 000.
↑Lieberman (2016). "Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores". Nature. 535 (7610): 153-8.
↑Lieberman (2016). "Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores". Nature. 535 (7610): 153-8.
Further reading
Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, Yanagihara K, Ogawa K, Sakamoto H, Yoshida T, Sasaki H (2009). "Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium". Genes Chromosomes Cancer. 48 (3): 261–71. doi:10.1002/gcc.20636. PMID19051310.
