GRK6

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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
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RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

G protein-coupled receptor kinase 6 is an enzyme that in humans is encoded by the GRK6 gene.

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. GRK6 appears to be involved in responses to morphine.

Further reading

• Bullrich F, Druck T, Kunapuli P, et al. (1995). "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6". Cytogenet. Cell Genet. 70 (3–4): 250–4. doi:10.1159/000134045. PMID 7789183.
• Stoffel RH, Randall RR, Premont RT, et al. (1994). "Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family". J. Biol. Chem. 269 (45): 27791–4. PMID 7961702.
• Loudon RP, Benovic JL (1994). "Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6". J. Biol. Chem. 269 (36): 22691–7. PMID 8077221.
• Benovic JL, Gomez J (1993). "Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family". J. Biol. Chem. 268 (26): 19521–7. PMID 8366096.
• Freedman NJ, Ament AS, Oppermann M, et al. (1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity". J. Biol. Chem. 272 (28): 17734–43. doi:10.1074/jbc.272.28.17734. PMID 9211925.
• Loudon RP, Benovic JL (1997). "Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6". J. Biol. Chem. 272 (43): 27422–7. doi:10.1074/jbc.272.43.27422. PMID 9341194.
• Stoffel RH, Inglese J, Macrae AD, et al. (1998). "Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6". Biochemistry. 37 (46): 16053–9. doi:10.1021/bi981432d. PMID 9819198.
• Premont RT, Claing A, Vitale N, et al. (1998). "β2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14082–7. doi:10.1073/pnas.95.24.14082. PMC 24330. PMID 9826657.
• Milcent MD, Christophe T, Rabiet MJ, et al. (1999). "Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells". Biochem. Biophys. Res. Commun. 259 (1): 224–9. doi:10.1006/bbrc.1999.0758. PMID 10334944.
• Lazari MF, Liu X, Nakamura K, et al. (1999). "Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor". Mol. Endocrinol. 13 (6): 866–78. doi:10.1210/me.13.6.866. PMID 10379886.
• Hall RA, Spurney RF, Premont RT, et al. (1999). "G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction". J. Biol. Chem. 274 (34): 24328–34. doi:10.1074/jbc.274.34.24328. PMID 10446210.
• Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S (1999). "Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium". J. Endocrinol. 162 (3): 401–8. doi:10.1677/joe.0.1620401. PMID 10467231.
• Premont RT, Macrae AD, Aparicio SA, et al. (1999). "The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation". J. Biol. Chem. 274 (41): 29381–9. doi:10.1074/jbc.274.41.29381. PMID 10506199.
• Pronin AN, Morris AJ, Surguchov A, Benovic JL (2000). "Synucleins are a novel class of substrates for G protein-coupled receptor kinases". J. Biol. Chem. 275 (34): 26515–22. doi:10.1074/jbc.M003542200. PMID 10852916.
• Tiruppathi C, Yan W, Sandoval R, et al. (2000). "G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7440–5. doi:10.1073/pnas.97.13.7440. PMC 16564. PMID 10861009.
• Zhou H, Yan F, Tai HH (2001). "Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases". J. Pharmacol. Exp. Ther. 298 (3): 1243–51. PMID 11504827.
• Blaukat A, Pizard A, Breit A, et al. (2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function". J. Biol. Chem. 276 (44): 40431–40. doi:10.1074/jbc.M107024200. PMID 11517230.
• Willets JM, Challiss RA, Nahorski SR (2002). "Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells". J. Biol. Chem. 277 (18): 15523–9. doi:10.1074/jbc.M111217200. PMID 11856737.
• Grange-Midroit M, García-Sevilla JA, Ferrer-Alcón M, et al. (2002). "G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution". Brain Res. Mol. Brain Res. 101 (1–2): 39–51. doi:10.1016/S0169-328X(02)00144-4. PMID 12007830.