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G protein-coupled receptor 112 is a protein encoded by the ADGRG4gene.[1][2] GPR112 is a member of the adhesion GPCR family.[3][4]
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5]
GPR112 is expressed in human enterochromaffin cells[6] and in the mouse intestine.[7] The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules.[7] GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.[6]
↑Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN1-4419-7912-3.
↑Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID23695165.