GNG3
| Guanine nucleotide binding protein (G protein), gamma 3 | |||||||||||
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| Symbols | GNG3 ; | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 22575 | ||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Guanine nucleotide binding protein (G protein), gamma 3, also known as GNG3, is a human gene.[1]
G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM][1]
References
Further reading
- Wedegaertner PB, Wilson PT, Bourne HR (1995). "Lipid modifications of trimeric G proteins". J. Biol. Chem. 270 (2): 503–6. PMID 7822269.
- Downes GB, Gautam N (2000). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
- Garcia-Higuera I, Thomas TC, Yi F, Neer EJ (1996). "Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma". J. Biol. Chem. 271 (1): 528–35. PMID 8550614.
- Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. PMID 8636150.
- Morishita R, Saga S, Kawamura N; et al. (1997). "Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain". J. Neurochem. 68 (2): 820–7. PMID 9003074.
- Bell B, Xing H, Yan K; et al. (1999). "KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation". J. Biol. Chem. 274 (12): 7982–6. PMID 10075696.
- Hurowitz EH, Melnyk JM, Chen YJ; et al. (2000). "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes". DNA Res. 7 (2): 111–20. PMID 10819326.
- Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001). "Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq". J. Biol. Chem. 276 (26): 23945–53. doi:10.1074/jbc.M101154200. PMID 11294873.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Cuello F, Schulze RA, Heemeyer F; et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
- Kato C, Mizutani T, Tamaki H; et al. (2004). "Characterization of heterotrimeric G protein complexes in rice plasma membrane". Plant J. 38 (2): 320–31. doi:10.1111/j.1365-313X.2004.02046.x. PMID 15078334.
- Schwindinger WF, Giger KE, Betz KS; et al. (2004). "Mice with deficiency of G protein gamma3 are lean and have seizures". Mol. Cell. Biol. 24 (17): 7758–68. doi:10.1128/MCB.24.17.7758-7768.2004. PMID 15314181.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
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