GAS7: Difference between revisions

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'''Growth arrest-specific protein 7''' is a [[protein]] that in humans is encoded by the ''GAS7'' [[gene]].<ref name="pmid9736752">{{cite journal |vauthors=Ju YT, Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S | title = gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 19 | pages = 11423–11428 |date=Oct 1998 | pmid = 9736752 | pmc = 21658 | doi =10.1073/pnas.95.19.11423 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GAS7 growth arrest-specific 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8522| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Growth arrest-specific 7
| HGNCid = 4169
| Symbol = GAS7
| AltSymbols =; MLL/GAS7; KIAA0394; MGC1348
| OMIM = 603127
| ECnumber = 
| Homologene = 69015
| MGIid = 1202388
| GeneAtlas_image1 = PBB_GE_GAS7_202191_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GAS7_202192_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GAS7_207704_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005884 |text = actin filament}}
| Process = {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0030041 |text = actin filament polymerization}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0051017 |text = actin filament bundle formation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8522
    | Hs_Ensembl = ENSG00000007237
    | Hs_RefseqProtein = NP_003635
    | Hs_RefseqmRNA = NM_003644
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 9754651
    | Hs_GenLoc_end = 10042593
    | Hs_Uniprot = O60861
    | Mm_EntrezGene = 14457
    | Mm_Ensembl = ENSMUSG00000033066
    | Mm_RefseqmRNA = NM_008088
    | Mm_RefseqProtein = NP_032114
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 67363349
    | Mm_GenLoc_end = 67501169
    | Mm_Uniprot = Q0VBR8
  }}
}}
'''Growth arrest-specific 7''', also known as '''GAS7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GAS7 growth arrest-specific 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8522| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.<ref name="entrez">{{cite web | title = Entrez Gene: GAS7 growth arrest-specific 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8522| accessdate = }}</ref>
| summary_text = Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kurtz A, Zimmer A |title=Interspecies fluorescence in situ hybridization further defines synteny homology between mouse chromosome 11 and human chromosome 17. |journal=Mamm. Genome |volume=6 |issue= 5 |pages= 379-80 |year= 1995 |pmid= 7626897 |doi=  }}
*{{cite journal  |vauthors=Kurtz A, Zimmer A |title=Interspecies fluorescence in situ hybridization further defines synteny homology between mouse chromosome 11 and human chromosome 17 |journal=Mamm. Genome |volume=6 |issue= 5 |pages= 379–380 |year= 1995 |pmid= 7626897 |doi=10.1007/BF00364810 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–174 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–156 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S }}
*{{cite journal  | author=Ishikawa K, Nagase T, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 5 |pages= 307-13 |year= 1998 |pmid= 9455477 |doi=  }}
*{{cite journal  | author=Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=4 |issue= 5 |pages= 307–313 |year= 1998 |pmid= 9455477 |doi=10.1093/dnares/4.5.307  |name-list-format=vanc| author2=Nagase T | author3=Nakajima D  | display-authors=3  | last4=Seki  | first4=N  | last5=Ohira | first5=M  | last6=Miyajima  | first6=N  | last7=Tanaka  | first7=A  | last8=Kotani  | first8=H  | last9=Nomura  | first9=N }}
*{{cite journal | author=Ju YT, Chang AC, She BR, ''et al.'' |title=gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11423-8 |year= 1998 |pmid= 9736752 |doi=  }}
*{{cite journal  | author=Megonigal MD |title=Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2814–2819 |year= 2000 |pmid= 10706619 |doi= 10.1073/pnas.050397097 | pmc=16012  |name-list-format=vanc| author2=Cheung NK  | author3=Rappaport EF  | display-authors=3  | last4=Nowell  | first4=PC  | last5=Wilson  | first5=RB  | last6=Jones  | first6=DH  | last7=Addya  | first7=K  | last8=Leonard  | first8=DG  | last9=Kushner  | first9=BH }}
*{{cite journal  | author=Megonigal MD, Cheung NK, Rappaport EF, ''et al.'' |title=Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2814-9 |year= 2000 |pmid= 10706619 |doi= 10.1073/pnas.050397097 }}
*{{cite journal  |vauthors=She BR, Liou GG, Lin-Chao S |title=Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth |journal=Exp. Cell Res. |volume=273 |issue= 1 |pages= 34–44 |year= 2002 |pmid= 11795944 |doi= 10.1006/excr.2001.5435 }}
*{{cite journal  | author=She BR, Liou GG, Lin-Chao S |title=Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth. |journal=Exp. Cell Res. |volume=273 |issue= 1 |pages= 34-44 |year= 2002 |pmid= 11795944 |doi= 10.1006/excr.2001.5435 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Chao CC, Chang PY, Lu HH |title=Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth |journal=J. Neurosci. Res. |volume=81 |issue= 2 |pages= 153–162 |year= 2005 |pmid= 15948147 |doi= 10.1002/jnr.20552 }}
*{{cite journal  | author=Chao CC, Chang PY, Lu HH |title=Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth. |journal=J. Neurosci. Res. |volume=81 |issue= 2 |pages= 153-62 |year= 2005 |pmid= 15948147 |doi= 10.1002/jnr.20552 }}
}}
}}
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Revision as of 08:39, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Growth arrest-specific protein 7 is a protein that in humans is encoded by the GAS7 gene.[1][2]

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.[2]

References

  1. ↑ Ju YT, Chang AC, She BR, Tsaur ML, Hwang HM, Chao CC, Cohen SN, Lin-Chao S (Oct 1998). "gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation". Proc Natl Acad Sci U S A. 95 (19): 11423–11428. doi:10.1073/pnas.95.19.11423. PMC 21658. PMID 9736752.
  2. ↑ 2.0 2.1 "Entrez Gene: GAS7 growth arrest-specific 7".

Further reading



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