GAL3ST1

Galactose-3-O-sulfotransferase 1
Identifiers
Symbols	GAL3ST1 ; CST
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3574
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Galactose-3-O-sulfotransferase 1, also known as GAL3ST1, is a human gene.

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.

Further reading

• Siegrist HP, Jutzi H, Steck AJ; et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochim. Biophys. Acta. 489 (1): 58–63. PMID 911873.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stein C, Gieselmann V, Kreysing J; et al. (1989). "Cloning and expression of human arylsulfatase A.". J. Biol. Chem. 264 (2): 1252–9. PMID 2562955.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochem. Biophys. Res. Commun. 52 (3): 951–8. PMID 4710574.
• Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694–702. PMID 5562350.
• Costantino-Ceccarini E, Waehneldt TV, Ginalski H; et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res. 7 (1): 1–12. PMID 6280086.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. Neurochem. 38 (1): 233–41. PMID 6955451.CS1 maint: Multiple names: authors list (link)
• Honke K, Yamane M, Ishii A; et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells". J. Biochem. 119 (3): 421–7. PMID 8830034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Honke K, Tsuda M, Hirahara Y; et al. (1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J. Biol. Chem. 272 (8): 4864–8. PMID 9030544.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Tsuda M, Egashira M, Niikawa N; et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene". Eur. J. Biochem. 267 (9): 2672–9. PMID 10785389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase". Biochem. J. 368 (Pt 1): 317–24. doi:10.1042/BJ20020946. PMID 12175333.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)