GADD45A
| Growth arrest and DNA-damage-inducible, alpha | |||||||||||
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| Symbols | GADD45A ; DDIT1; GADD45 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1449 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Growth arrest and DNA-damage-inducible, alpha, also known as GADD45A, is a human gene.[1]
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.[1]
See also
References
Further reading
- Hildesheim J, Fornace AJ (2003). "Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer". Clin. Cancer Res. 8 (8): 2475–9. PMID 12171872.
- Papathanasiou MA, Kerr NC, Robbins JH; et al. (1991). "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.". Mol. Cell. Biol. 11 (2): 1009–16. PMID 1990262.
- Chen IT, Smith ML, O'Connor PM, Fornace AJ (1995). "Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA". Oncogene. 11 (10): 1931–7. PMID 7478510.
- Kearsey JM, Coates PJ, Prescott AR; et al. (1995). "Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1". Oncogene. 11 (9): 1675–83. PMID 7478594.
- Hall PA, Kearsey JM, Coates PJ; et al. (1995). "Characterisation of the interaction between PCNA and Gadd45". Oncogene. 10 (12): 2427–33. PMID 7784094.
- Carrier F, Smith ML, Bae I; et al. (1995). "Characterization of human Gadd45, a p53-regulated protein". J. Biol. Chem. 269 (51): 32672–7. PMID 7798274.
- Smith ML, Chen IT, Zhan Q; et al. (1994). "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen". Science. 266 (5189): 1376–80. PMID 7973727.
- Hollander MC, Alamo I, Jackman J; et al. (1993). "Analysis of the mammalian gadd45 gene and its response to DNA damage". J. Biol. Chem. 268 (32): 24385–93. PMID 8226988.
- Warbrick E, Lane DP, Glover DM, Cox LS (1997). "Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair". Oncogene. 14 (19): 2313–21. doi:10.1038/sj.onc.1201072. PMID 9178907.
- Warbrick E, Heatherington W, Lane DP, Glover DM (1998). "PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain". Nucleic Acids Res. 26 (17): 3925–32. PMID 9705499.
- Takekawa M, Saito H (1998). "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK". Cell. 95 (4): 521–30. PMID 9827804.
- Carrier F, Georgel PT, Pourquier P; et al. (1999). "Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin". Mol. Cell. Biol. 19 (3): 1673–85. PMID 10022855.
- Zhan Q, Antinore MJ, Wang XW; et al. (1999). "Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45". Oncogene. 18 (18): 2892–900. doi:10.1038/sj.onc.1202667. PMID 10362260.
- Jin S, Antinore MJ, Lung FD; et al. (2000). "The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression". J. Biol. Chem. 275 (22): 16602–8. doi:10.1074/jbc.M000284200. PMID 10747892.
- Vairapandi M, Azam N, Balliet AG; et al. (2000). "Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control". J. Biol. Chem. 275 (22): 16810–9. PMID 10828065.
- Yi YW, Kim D, Jung N; et al. (2000). "Gadd45 family proteins are coactivators of nuclear hormone receptors". Biochem. Biophys. Res. Commun. 272 (1): 193–8. PMID 10872826.
- Zhao H, Jin S, Antinore MJ; et al. (2000). "The central region of Gadd45 is required for its interaction with p21/WAF1". Exp. Cell Res. 258 (1): 92–100. doi:10.1006/excr.2000.4906. PMID 10912791.
- Yang Q, Manicone A, Coursen JD; et al. (2001). "Identification of a functional domain in a GADD45-mediated G2/M checkpoint". J. Biol. Chem. 275 (47): 36892–8. doi:10.1074/jbc.M005319200. PMID 10973963.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Kovalsky O, Lung FD, Roller PP, Fornace AJ (2001). "Oligomerization of human Gadd45a protein". J. Biol. Chem. 276 (42): 39330–9. doi:10.1074/jbc.M105115200. PMID 11498536.
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