GABRD

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.

Function

γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA_A receptors, which are ligand-gated chloride channels. The GABA_A receptor is generally pentameric. Its five subunits are alpha, beta, gamma, delta, and rho. The GABRD gene encodes the delta subunit. Specifically, the δ-subunit is usually expressed in GABA_A receptors associated with extrasynaptic activity. The most common GABA_A receptors have the gamma subunit, which allows the receptor to bind benzodiazepines. For this reason, receptors containing δ-subunits are sometimes referred to as “benzodiazepine insensitive” GABA_A receptors. The δ-subunit containing receptors are also known to be involved in the ventral tegmental area (VTA) pathway in the brain's hippocampus, which means that they may have implications in learning, memory, and reward.

Cell type-specific expression

In a technical comparison between quantitative reverse transcriptase PCR and digital PCR, the expression of the rat gabrd gene was examined across three cell types in the somatosensory cortex: neurogliaform cells, fast spiking basket cells and pyramidal cells. Gene expression was detected in all three cell types, but showed marked enrichment in neurogliaform cells versus the other cell types examined.

See also

• GABA_A receptor

Further reading

• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Lenzen KP, Heils A, Lorenz S, Hempelmann A, Sander T (Jun 2005). "Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy". Epilepsy Research. 65 (1–2): 53–7. doi:10.1016/j.eplepsyres.2005.04.005. PMID 16023832.
• Windpassinger C, Kroisel PM, Wagner K, Petek E (Jun 2002). "The human gamma-aminobutyric acid A receptor delta (GABRD) gene: molecular characterisation and tissue-specific expression". Gene. 292 (1–2): 25–31. doi:10.1016/S0378-1119(02)00649-2. PMID 12119096.

External links

• GABRD+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.