Fusafungine: Difference between revisions
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{{ | {{Drugbox | ||
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| | | Drugs.com = {{drugs.com|international|fusafungine}} | ||
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | |||
| | | pregnancy_US = <!-- A / B / C / D / X --> | ||
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| | | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> | ||
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> | |||
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> | |||
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | |||
| pregnancy_AU | | legal_status = | ||
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| legal_AU | <!--Pharmacokinetic data--> | ||
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| CAS_number_Ref = {{cascite|correct|??}} | |||
| CAS_number = 1393-87-9 | |||
| ATC_prefix = R02 | |||
| ATC_suffix = AB03 | |||
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| DrugBank_Ref = {{drugbankcite|changed|drugbank}} | |||
| DrugBank = DB08965 | |||
| UNII_Ref = {{fdacite|correct|FDA}} | |||
| UNII = 65DD690W0C | |||
| KEGG_Ref = {{keggcite|changed|kegg}} | |||
| KEGG = D08002 | |||
<!--Chemical data--> | |||
| C=29 | H=51 | N=2 | O=8 | |||
| molecular_weight = 555.72 g/mol<ref>[http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?term=Fusafungin&field=all Fusafungine] at [[Medical Subject Headings|MeSH]]</ref> | |||
| synonyms = Fusafungin | |||
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{{SI}} | {{SI}} | ||
{{CMG}} | {{CMG}} | ||
{{ | ==Overview== | ||
'''Fusafungine''' ([[International Nonproprietary Name|INN]]), also known as '''fusafungin''', is an active agent used in [[antibiotic]]s for treatment of [[nasal infection|nasal]] and [[throat infection]]. It also possesses [[anti-inflammatory]] properties. Fusafungine is a mixture of [[enniatin]] [[depsipeptide|cyclohexadepsipeptides]] made up of alternating <small>D</small>-α-hydroxyvaleric acid and <small>L</small>-''N''-methylamino acid residues,<ref>{{cite journal | journal = [[Biochemical Pharmacology]] | volume =50 |issue=12 22 |year=1995 |pages= 2105–2107 | title=Alkali cation transport through liposomes by the antimicrobial fusafungine and its constitutive enniatins | author = Daniel Levy, Aline Bluzat, Michel Seigneuret and Jean-Louis Rigaud| doi = 10.1016/0006-2952(95)02045-4 | pmid=8849339}}</ref> produced by the [[Ascomycota|ascomycete]] ''Fusarium lateritium'', and marketed by [[Servier]] under the trade names '''Locabiotal''', '''Bioparox''', and '''Locabiosol'''. | |||
According to a pooled analysis study done in the UK for the efficacy of fusafungine in [[Rhinopharyngitis|rhinopharingitis]], it was found that the proportion of patients who showed an improvement in symptoms from Day 0 to Day 4 of infection was 61.5% with fusafungine vs. 46.8% when compared to a placebo.<ref>{{cite pmid|15626253}}</ref> | |||
==References== | |||
{{reflist|2}} | |||
{{Throat preparations}} | {{Throat preparations}} | ||
[[Category:Antimicrobial peptides]] | [[Category:Antimicrobial peptides]] | ||
[[Category:Drug]] | |||
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Latest revision as of 16:34, 13 April 2015
Clinical data | |
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Synonyms | Fusafungin |
AHFS/Drugs.com | International Drug Names |
ATC code | |
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DrugBank | |
UNII | |
KEGG | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C29H51N2O8 |
Molar mass | 555.72 g/mol[1] |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Fusafungine (INN), also known as fusafungin, is an active agent used in antibiotics for treatment of nasal and throat infection. It also possesses anti-inflammatory properties. Fusafungine is a mixture of enniatin cyclohexadepsipeptides made up of alternating D-α-hydroxyvaleric acid and L-N-methylamino acid residues,[2] produced by the ascomycete Fusarium lateritium, and marketed by Servier under the trade names Locabiotal, Bioparox, and Locabiosol.
According to a pooled analysis study done in the UK for the efficacy of fusafungine in rhinopharingitis, it was found that the proportion of patients who showed an improvement in symptoms from Day 0 to Day 4 of infection was 61.5% with fusafungine vs. 46.8% when compared to a placebo.[3]
References
- ↑ Fusafungine at MeSH
- ↑ Daniel Levy, Aline Bluzat, Michel Seigneuret and Jean-Louis Rigaud (1995). "Alkali cation transport through liposomes by the antimicrobial fusafungine and its constitutive enniatins". Biochemical Pharmacology. 50 (12 22): 2105–2107. doi:10.1016/0006-2952(95)02045-4. PMID 8849339.
- ↑ PMID 15626253 (PMID 15626253)
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