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Prognosis is generally poor and the 5 year survival rate of patients with follicular lymphoma is approximately 72-77%.
Prognosis is generally poor and the 5 year survival rate of patients with follicular lymphoma is approximately 72-77%.
==Prognosis==
==Prognosis==
*Follicular lymphoma is regarded as incurable (although allogenic [[stem cell transplantation]] may be curative, the mortality from the procedure is too high to be a first line option). The [[median]] survival is around 10 years, but the range is wide, from less than one year, to more than 20 years. Some patients may never need treatment. The overall survival rate at 5 years is 72-77%<ref>{{EMedicine|article|203268|Lymphoma, Follicular}}</ref>.
*Follicular lymphoma is regarded as incurable (although allogenic [[stem cell transplantation]] may be curative, the mortality from the procedure is too high to be a first line option). The [[median]] survival is around 10 years, but the range is wide, from less than one year, to more than 20 years. Some patients may never need treatment. The overall survival rate at 5 years is 72-77%.<ref>{{EMedicine|article|203268|Lymphoma, Follicular}}</ref>
*Follicular lymphoma is graded according to the proportion of large cells (centroblasts). Studies suggest this histologic grading predicts clinical outcome, with more large cells behaving more aggressively and having a higher likelihood of transformation to diffuse large cell lymphoma. When any area of diffuse large-B-cell lymphoma is present in a follicular lymphoma the disease should be reported as diffuse large B-cell lymphoma<ref name="seer">National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>.  
*The following factors are associated with poor prognosis:<ref name="seer">National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>.
*There was no difference in survival outcomes between patients with Grade 3A and 3B follicular lymphoma, whereas patients with Grade 3 follicular lymphoma with more than 50% diffuse component have an inferior survival similar to the survival of those with diffuse large cell lymphoma.
:*Grade 3 histopathologic grading
*Grade 3B follicular lymphoma with cytogenetic abnormalities of ''BCL6'' (at 3q27) are thought to be genetically more akin to germinal center type diffuse large B-cell lymphoma than Grade 1-3A follicular lymphoma, and is associated with a more aggressive clinical course.
:*Presence of cytogenic abnormalities of ''BCL-6'' gene
*Patients with Grade-3B follicular lymphoma with ''BCL2'' [[translocation]] appear to have a clinical course similar to patients with Grade 3A follicular lymphoma. Since Grade 3B follicular lymphoma is rare, the clinical behavior of Grade 3 follicular lymphoma in most studies is based mainly on Grade 3A follicular lymphoma cases.


==References==
==References==

Revision as of 13:55, 2 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Prognosis is generally poor and the 5 year survival rate of patients with follicular lymphoma is approximately 72-77%.

Prognosis

  • Follicular lymphoma is regarded as incurable (although allogenic stem cell transplantation may be curative, the mortality from the procedure is too high to be a first line option). The median survival is around 10 years, but the range is wide, from less than one year, to more than 20 years. Some patients may never need treatment. The overall survival rate at 5 years is 72-77%.[1]
  • The following factors are associated with poor prognosis:[2].
  • Grade 3 histopathologic grading
  • Presence of cytogenic abnormalities of BCL-6 gene


References

  1. Lymphoma, Follicular at eMedicine
  2. National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov