Folate deficiency historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Historical Perspective
Discovery
- Folate deficiency was first discovered by Lucy Wills, an English hematologist, in 1931 while conducting seminal work in India in the late 1920s and early 1930s on macrocytic anemia of pregnancy. During her study, she found that this nutrient was needed to prevent the anemia of pregnancy. Dr. Wills demonstrated that this condition could be reversed with brewer's yeast.
- It was in the later 1930’s that folate, the naturally occuring form of folic acid, was isolated from brewer's yeast and folic acid was identified in the pathogenesis of anemia in pregnant women.
- In August 1943, Lederle Laboratory scientists, isolated folate crystals feom one and half tons of liver,determined its structure and synthesized it.
- [Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].
- The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
- In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
- In August 1943, Lederle Laboratory scientists, isolated folate crystals feom one and half tons of liver,determined its structure and synthesized it.
Landmark Events in the Development of Treatment Strategies
Impact on Cultural History
Famous Cases
The following are a few famous cases of [disease name]: