Flurbiprofen (oral)

Flurbiprofen (oral)
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]

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Black Box Warning

TITLE See full prescribing information for complete Boxed Warning. Condition Name: (Content)

Overview

Flurbiprofen (oral) is an analgesic, NSAID, propionic acid (class) that is FDA approved for the treatment of rheumathoid arthritis and osteoarthritis. There is a Black Box Warning for this drug as shown here. Common adverse reactions include body fluid retention, edema, rash, weight change finding, abdominal pain, constipation, diarrhea, flatulence, heartburn, indigestion, nausea, vomiting, increased liver function test, central nervous system depression, central nervous system stimulation, dizziness, headache, abnormal vision, tinnitus, feeling nervous, rhinitis.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

There is limited information regarding Flurbiprofen (oral) FDA-Labeled Indications and Dosage (Adult) in the drug label.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Flurbiprofen in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Flurbiprofen in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Flurbiprofen (oral) FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Flurbiprofen in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Flurbiprofen in pediatric patients.

Contraindications

There is limited information regarding Flurbiprofen (oral) Contraindications in the drug label.

Warnings

TITLE See full prescribing information for complete Boxed Warning. Condition Name: (Content)

There is limited information regarding Flurbiprofen (oral) Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Flurbiprofen (oral) Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Flurbiprofen (oral) Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Flurbiprofen (oral) Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Flurbiprofen (oral) in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Flurbiprofen (oral) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Flurbiprofen (oral) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Flurbiprofen (oral) in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Flurbiprofen (oral) in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Flurbiprofen (oral) in geriatric settings.

Gender

There is no FDA guidance on the use of Flurbiprofen (oral) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Flurbiprofen (oral) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Flurbiprofen (oral) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Flurbiprofen (oral) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Flurbiprofen (oral) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Flurbiprofen (oral) in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Flurbiprofen (oral) Administration in the drug label.

Monitoring

There is limited information regarding Flurbiprofen (oral) Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Flurbiprofen (oral) and IV administrations.

Overdosage

There is limited information regarding Flurbiprofen (oral) overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Flurbiprofen (oral) Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Flurbiprofen (oral) Mechanism of Action in the drug label.

Structure

There is limited information regarding Flurbiprofen (oral) Structure in the drug label.

Pharmacodynamics

There is limited information regarding Flurbiprofen (oral) Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Flurbiprofen (oral) Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Flurbiprofen (oral) Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Flurbiprofen (oral) Clinical Studies in the drug label.

How Supplied

There is limited information regarding Flurbiprofen (oral) How Supplied in the drug label.

Storage

There is limited information regarding Flurbiprofen (oral) Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Flurbiprofen (oral) Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Flurbiprofen interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Flurbiprofen (oral) Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Flurbiprofen (oral) Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

Flurbiprofen (oral)

File:Flurbiprofen.svg
Clinical data
Pregnancy category	C (U.S.), B2 (Au)
Routes of administration	Oral
ATC code	M01AE09 (WHO) M02AA19 (WHO), S01BC04 (WHO)
Pharmacokinetic data
Protein binding	> 99%
Metabolism	Hepatic (CYP2C9)
Elimination half-life	4.7-5.7 hours
Excretion	Renal
Identifiers
IUPAC name 2-(3-fluoro-4-phenyl-phenyl)propanoic acid
CAS Number	5104-49-4
PubChem CID	3394
DrugBank	APRD00753
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C15H13FO2
Molar mass	244.261 g/mol

Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs) used to treat the inflammation and pain of arthritis. It is also known by the trade name ANSAID and marketed by Pfizer.

Flurbiprofen is also used as an active ingredient in some kinds of throat lozenges.

R-flurbiprofen is the single enantiomer of racemate flurbiprofen; this compound is currently in clinical trials for the treatment of metastatic prostate cancer, and Alzheimer's disease.

Flurbiprofen was mocked by television satirist Stephen Colbert (for its unlikely name) during an interview with Terry Gross aired on October 9, 2007 on National Public Radio's program "Fresh Air." Colbert had been taking the drug after breaking his wrist earlier that year.