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==Overview==
 
==Overview==
 
Dupont et al described in 1994 the risk of invasive breast cancer in patients with fibroadenoma. Later in a study with Carter, atypia within a fibroadenoma was assessed for the risk of cancer development. In another study, the excision of a complex fibroadenoma discovered via core biopsy was advised.
 
Dupont et al described in 1994 the risk of invasive breast cancer in patients with fibroadenoma. Later in a study with Carter, atypia within a fibroadenoma was assessed for the risk of cancer development. In another study, the excision of a complex fibroadenoma discovered via core biopsy was advised.

Latest revision as of 03:23, 14 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe M.D. [2] Haytham Allaham, M.D. [3]

Overview

Dupont et al described in 1994 the risk of invasive breast cancer in patients with fibroadenoma. Later in a study with Carter, atypia within a fibroadenoma was assessed for the risk of cancer development. In another study, the excision of a complex fibroadenoma discovered via core biopsy was advised.

Historical Perspective

  • In 1994, Dupont et al addressed in their retrospective cohort study that fibroadenoma is associated with a long term risk of invasive breast cancer, with the risk further increased in women with complex fibroadenomas, a family history of breast cancer and those with proliferative disease. Later in a study with Carter in 2001, they found that the presence of atypia within a fibroadenoma cannot foretell the presence of one in the adjacent breast parenchyma. They also found that atypia within a fibroadenoma does not present a relevant risk of development of breast cancer greater than that of a fibroadenoma with no atypia within.[1][2]
  • In 2008, Solar-Levy et al reported the presence of invasive lobular carcinoma in about 1.6% of patients with complex fibroadenomas and advised that any complex fibroadenoma with a high risk lesion on core biopsy should be excised. They also recommended that simple fibroadenomas with a volume growth rate of less than 16% per month (in patients younger than 50 years of age) and less than 13% per month (more than 50 years) should be followed up with imaging studies.[3][4][5]

References

  1. Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD, Rados MS; et al. (1994). "Long-term risk of breast cancer in women with fibroadenoma". N Engl J Med. 331 (1): 10–5. doi:10.1056/NEJM199407073310103. PMID 8202095.
  2. Carter BA, Page DL, Schuyler P, Parl FF, Simpson JF, Jensen RA; et al. (2001). "No elevation in long-term breast carcinoma risk for women with fibroadenomas that contain atypical hyperplasia". Cancer. 92 (1): 30–6. PMID 11443606.
  3. Sklair-Levy M, Sella T, Alweiss T, Craciun I, Libson E, Mally B (2008). "Incidence and management of complex fibroadenomas". AJR Am J Roentgenol. 190 (1): 214–8. doi:10.2214/AJR.07.2330. PMID 18094314.
  4. Sanders LM, Sara R (2015). "The growing fibroadenoma". Acta Radiol Open. 4 (4): 2047981615572273. doi:10.1177/2047981615572273. PMC 4406922. PMID 25922691.
  5. Gordon PB, Gagnon FA, Lanzkowsky L (2003). "Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: acceptable rates of growth at long-term follow-up". Radiology. 229 (1): 233–8. doi:10.1148/radiol.2291010282. PMID 14519878.

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