Fibroadenoma classification: Difference between revisions

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{{Fibroadenoma}}
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==Overview==
==Overview==
Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.<ref name="patho">Fibroadenoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Fibroadenoma Accessed on January, 29 2016</ref>
Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, giant fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.
 
==Classification==
==Classification==
* Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include:<ref name="patho">Fibroadenoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Fibroadenoma Accessed on January, 29 2016</ref>  
* Fibroadenoma may be classified according to microscopic histopathological analysis into five subtypes, which include:<ref name="pmid24872735">{{cite journal| author=Cerrato F, Labow BI| title=Diagnosis and management of fibroadenomas in the adolescent breast. | journal=Semin Plast Surg | year= 2013 | volume= 27 | issue= 1 | pages= 23-5 | pmid=24872735 | doi=10.1055/s-0033-1343992 | pmc=3706050 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24872735  }} </ref>
:* Juvenile fibroadenoma  
:* Juvenile fibroadenoma  
:* Complex fibroadenoma  
:* Complex fibroadenoma  
:* Giant fibroadenoma
:* Myxoid fibroadenoma
:* Myxoid fibroadenoma
:* Cellular fibroadenoma  
:* Cellular fibroadenoma
 
* The table below differentiates between the main subtypes of fibrodenoma according to microscopic histopathological analysis:<ref name="pmid24872735">{{cite journal| author=Cerrato F, Labow BI| title=Diagnosis and management of fibroadenomas in the adolescent breast. | journal=Semin Plast Surg | year= 2013 | volume= 27 | issue= 1 | pages= 23-5 | pmid=24872735 | doi=10.1055/s-0033-1343992 | pmc=3706050 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24872735  }} </ref><ref name="pmid29546008">{{cite journal| author=Giannos A, Stavrou S, Gkali C, Chra E, Marinopoulos S, Chalazonitis A et al.| title=A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review. | journal=Int J Surg Case Rep | year= 2017 | volume= 41 | issue=  | pages= 427-430 | pmid=29546008 | doi=10.1016/j.ijscr.2017.11.026 | pmc=5702868 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29546008  }} </ref><ref name="pmid9754521">{{cite journal| author=Greenberg R, Skornick Y, Kaplan O| title=Management of breast fibroadenomas. | journal=J Gen Intern Med | year= 1998 | volume= 13 | issue= 9 | pages= 640-5 | pmid=9754521 | doi= | pmc=1497021 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9754521  }} </ref>
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
|valign=top|
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! style="background: #4479BA; width: 250px; color: #FFFFFF;"|'''Fibroadenoma Subtype'''
 
! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Description'''
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Juvenile fibroadenoma '''|| style="padding: 5px 5px; background: #F5F5F5;" |
:* Commonly found in ages 10 to 18 years.
:* Stromal and epithelial hyperplasia
:* Tapering, thin micropapillae (gynecomastoid hyperplasia)
:* Mitoses is absent
:* Occurs mostly in African Americans
:* Rapid growth
:* Associated with skin ulcerations and prominent veins
:* Referred to as a giant fibroadenoma when it is >5cm, >500g, or replaces more than 80% of the breast
 
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Complex fibroadenoma '''|| style="padding: 5px 5px; background: #F5F5F5;"|
:* Excessive proliferation of epithelial cells
:* Apocrine metaplasia
:* Cysts > 3 mm
:* Calcification
:* Sclerosing adenosis
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Giant fibroadenoma ''' || style="padding: 5px 5px; background: #F5F5F5;"|
:* >5cm in diameter
:* High stromal cellularity
:* Rapid growth
:* Usually seen in pregnant or lactating women
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Myxoid fibroadenoma'''|| style="padding: 5px 5px; background: #F5F5F5;"|
:* Myxoid stroma
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Cellular fibroadenoma '''|| style="padding: 5px 5px; background: #F5F5F5;" |
:* Relatively high cellular component 
:* Increased mitotic rate
:* Absence of calcification and sclerosing adenosis
:* Sometimes referred to as juvenile fibroadenoma
|}
 
==References==
==References==
{{reflist|1}}
{{reflist|1}}


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Latest revision as of 21:45, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe, M.D. [2] Haytham Allaham, M.D. [3]

Overview

Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, giant fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.

Classification

  • Fibroadenoma may be classified according to microscopic histopathological analysis into five subtypes, which include:[1]
  • Juvenile fibroadenoma
  • Complex fibroadenoma
  • Giant fibroadenoma
  • Myxoid fibroadenoma
  • Cellular fibroadenoma
  • The table below differentiates between the main subtypes of fibrodenoma according to microscopic histopathological analysis:[1][2][3]
Fibroadenoma Subtype Description
Juvenile fibroadenoma
  • Commonly found in ages 10 to 18 years.
  • Stromal and epithelial hyperplasia
  • Tapering, thin micropapillae (gynecomastoid hyperplasia)
  • Mitoses is absent
  • Occurs mostly in African Americans
  • Rapid growth
  • Associated with skin ulcerations and prominent veins
  • Referred to as a giant fibroadenoma when it is >5cm, >500g, or replaces more than 80% of the breast


Complex fibroadenoma
  • Excessive proliferation of epithelial cells
  • Apocrine metaplasia
  • Cysts > 3 mm
  • Calcification
  • Sclerosing adenosis
Giant fibroadenoma
  • >5cm in diameter
  • High stromal cellularity
  • Rapid growth
  • Usually seen in pregnant or lactating women
Myxoid fibroadenoma
  • Myxoid stroma
Cellular fibroadenoma
  • Relatively high cellular component
  • Increased mitotic rate
  • Absence of calcification and sclerosing adenosis
  • Sometimes referred to as juvenile fibroadenoma

References

  1. 1.0 1.1 Cerrato F, Labow BI (2013). "Diagnosis and management of fibroadenomas in the adolescent breast". Semin Plast Surg. 27 (1): 23–5. doi:10.1055/s-0033-1343992. PMC 3706050. PMID 24872735.
  2. Giannos A, Stavrou S, Gkali C, Chra E, Marinopoulos S, Chalazonitis A; et al. (2017). "A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review". Int J Surg Case Rep. 41: 427–430. doi:10.1016/j.ijscr.2017.11.026. PMC 5702868. PMID 29546008.
  3. Greenberg R, Skornick Y, Kaplan O (1998). "Management of breast fibroadenomas". J Gen Intern Med. 13 (9): 640–5. PMC 1497021. PMID 9754521.

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