Difference between revisions of "Fibroadenoma classification"

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==Overview==
 
==Overview==

Latest revision as of 03:24, 14 September 2019

Fibroadenoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe M.D. [2] Haytham Allaham, M.D. [3]

Overview

Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, giant fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.

Classification

  • Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include:[1]
  • Juvenile fibroadenoma
  • Complex fibroadenoma
  • Giant fibroadenoma
  • Myxoid fibroadenoma
  • Cellular fibroadenoma
  • The table below differentiates between the four main subtypes of fibrodenoma according to microscopic histopathological analysis:[1][2][3]
Fibroadenoma Subtype Description
Juvenile fibroadenoma
  • Commonly found in ages 10 to 18 years.
  • Stromal and epithelial hyperplasia
  • Tapering, thin micropapillae (gynecomastoid hyperplasia)
  • Mitoses is absent
  • Occurs mostly in African Americans
  • Rapid growth
  • Associated with skin ulcerations and prominent veins
  • Referred to as a giant fibroadenoma when it is >5cm, >500g, or replaces more than 80% of the breast


Complex fibroadenoma
  • Excessive proliferation of epithelial cells
  • Apocrine metaplasia
  • Cysts > 3 mm
  • Calcification
  • Sclerosing adenosis
Giant fibroadenoma
  • >5cm in diameter
  • High stromal cellularity
  • Rapid growth
  • Usually seen in pregnant or lactating women
Myxoid fibroadenoma
  • Myxoid stroma
Cellular fibroadenoma
  • Relatively high cellular component
  • Increased mitotic rate
  • Absence of calcification and sclerosing adenosis
  • Sometimes referred to as juvenile fibroadenoma

References

  1. 1.0 1.1 Cerrato F, Labow BI (2013). "Diagnosis and management of fibroadenomas in the adolescent breast". Semin Plast Surg. 27 (1): 23–5. doi:10.1055/s-0033-1343992. PMC 3706050. PMID 24872735.
  2. Giannos A, Stavrou S, Gkali C, Chra E, Marinopoulos S, Chalazonitis A; et al. (2017). "A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review". Int J Surg Case Rep. 41: 427–430. doi:10.1016/j.ijscr.2017.11.026. PMC 5702868. PMID 29546008.
  3. Greenberg R, Skornick Y, Kaplan O (1998). "Management of breast fibroadenomas". J Gen Intern Med. 13 (9): 640–5. PMC 1497021. PMID 9754521.

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