Familial adenomatous polyposis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

If left untreated, the majority of patients with familial adenomatous polyposis may progress to develop melena, [[diarrhea, and anemia. Common complications of familial adenomatous polyposis include colon cancer, and cachexia. Prognosis is generally excellent if colectomy was performed while the polyps are still confined to the inner wall of the colon.

Natural history

Without colectomy, the patient will develop symptoms of colon cancer, which will eventually lead to death.

Complications

Complications that can develop as a result of familial adenomatous polyposis are:

• Colon cancer
• Melena
• Cachexia
• Anemia

Prognosis

The prognosis of familial adenomatous polyposis is excellent with treatment. Without treatment, familial adenomatous polyposis will result in colon cancer.