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{{Fabry's disease}}
{{Fabry's disease}}


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{{CMG}} {{AE}} {{GhazalS}}


==Overview==
==Overview==
[[Fabry's disease]] is a rare condition with a [[prevalence]] of approximately 6:100,000 to 0.8:100,000 in men. This disease mostly affects men and has no rational disparities.


==Epidemiology and Demographics==
==Epidemiology and Demographics==


* FD belong to a group of lysosomal storage diseases that are related biochemically but not genetically.   
===Prevalence===
 
*In 2021, the [[prevalence]] of [[Fabry's disease|Fabry's]] disease was estimated to be approximately  6:100,000 to 0.8:100,000 in men.
*The [[prevalence]] of classic [[phenotype]] is estimated approximately 4.5:100,000 to 2.5:100,000 in men.
*The [[prevalence]] of atypical [[phenotype]] is about 100:100,000 to 33:100,000 in men and 16:100,000 to 2.5:100,000 in females.<ref name="pmid28613767">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume=  | issue=  | pages=  | pmid=28613767 | doi= | pmc= | url= }}</ref>
 
===Incidence===
 
*Incidence of [[Fabry's disease|Fabry's]] disease is commonly underestimated.<ref name="pmid28613767">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume=  | issue=  | pages= | pmid=28613767 | doi= | pmc= | url= }}</ref>


* It seems plausible to describe FD as a disease with a wide spectrum of clinical phenotypes. This spectrum includes the classical type that is more severe and predominant in males and the less common asymptomatic or variant type seen in some women carriers of the disease that encompasses a variety of clinical presentations.
===Gender===
* FD is a rare genetic disease that is pan ethnic in origin i.e no particular ethnicity is more involved than the other.
*


variant type is milder and occurs in adolescence or adulthood
*Men are more commonly affected with [[Fabry's disease]] than females. The male to female ratio is approximately 2 to 1.<ref name="pmid28613767">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume=  | issue=  | pages=  | pmid=28613767 | doi= | pmc= | url= }}</ref>


===Prevalence===
===Race===
The [[prevalence]] of Fabry disease is estimated to range from 1:17,000 to 1:117,000 males in Caucasian populations.
 
*The [[prevalence]] of Fabry's disease does not vary by race.<ref name="pmid28613767">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume=  | issue=  | pages=  | pmid=28613767 | doi= | pmc= | url= }}</ref>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
<references />
[[Category:Needs english review]]

Latest revision as of 10:28, 14 July 2022

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ghazal Sanadgol, M.D.[2]

Overview

Fabry's disease is a rare condition with a prevalence of approximately 6:100,000 to 0.8:100,000 in men. This disease mostly affects men and has no rational disparities.

Epidemiology and Demographics

Prevalence

  • In 2021, the prevalence of Fabry's disease was estimated to be approximately 6:100,000 to 0.8:100,000 in men.
  • The prevalence of classic phenotype is estimated approximately 4.5:100,000 to 2.5:100,000 in men.
  • The prevalence of atypical phenotype is about 100:100,000 to 33:100,000 in men and 16:100,000 to 2.5:100,000 in females.[1]

Incidence

  • Incidence of Fabry's disease is commonly underestimated.[1]

Gender

  • Men are more commonly affected with Fabry's disease than females. The male to female ratio is approximately 2 to 1.[1]

Race

References

  1. 1.0 1.1 1.2 1.3 "StatPearls". 2022. PMID 28613767.