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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminalPDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.[2]
↑Sagara N, Toda G, Hirai M, Terada M, Katoh M (Nov 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochemical and Biophysical Research Communications. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID9813155.
Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA (Oct 1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID10557084.
DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (May 2002). "The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor". Naunyn-Schmiedeberg's Archives of Pharmacology. 365 (5): 341–8. doi:10.1007/s00210-002-0540-3. PMID12012019.
Hering H, Sheng M (Jun 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Letters. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID12067714.
Zilberberg A, Yaniv A, Gazit A (Apr 2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway". The Journal of Biological Chemistry. 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID14739301.
Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID15370539.
Yang L, Yamasaki K, Shirakata Y, Dai X, Tokumaru S, Yahata Y, Tohyama M, Hanakawa Y, Sayama K, Hashimoto K (May 2006). "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes". Journal of Dermatological Science. 42 (2): 111–9. doi:10.1016/j.jdermsci.2005.12.011. PMID16442268.
External links
"Frizzled Receptors: FZD1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.