FUT7

Fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
Identifiers
Symbols	FUT7 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3296
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fucosyltransferase 7 (alpha (1,3) fucosyltransferase), also known as FUT7, is a human gene.

The sialyl Lewis x oligosaccharide determinant is an essential component of leukocyte counterreceptors for E-selectin- (MIM 131210) and P-selectin- (MIM 173610) mediated adhesions of leukocytes. This oligosaccharide molecule is displayed on the surfaces of granulocytes, monocytes, and natural killer cells. Formation of leukocyte adhesions to these selectins is an early and important step in the process that ultimately allows leukocytes to leave the vascular tree and become recruited into lymphoid tissues and sites of inflammation.[supplied by OMIM]

Further reading

• Natsuka S, Gersten KM, Zenita K; et al. (1994). "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant". J. Biol. Chem. 269 (32): 20806. PMID 8051184.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasaki K, Kurata K, Funayama K; et al. (1994). "Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes". J. Biol. Chem. 269 (20): 14730–7. PMID 8182079.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Natsuka S, Gersten KM, Zenita K; et al. (1994). "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant". J. Biol. Chem. 269 (24): 16789–94. PMID 8207002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith PL, Gersten KM, Petryniak B; et al. (1996). "Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands". J. Biol. Chem. 271 (14): 8250–9. PMID 8626519.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Le Marer N, Palcic MM, Clarke JL; et al. (1997). "Developmental regulation of alpha 1,3-fucosyltransferase expression in CD34 positive progenitors and maturing myeloid cells isolated from normal human bone marrow". Glycobiology. 7 (3): 357–65. PMID 9147044.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mas E, Pasqualini E, Caillol N; et al. (1998). "Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines". Glycobiology. 8 (6): 605–13. PMID 9592127.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bengtson P, Larson C, Lundblad A; et al. (2001). "Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene". J. Biol. Chem. 276 (34): 31575–82. doi:10.1074/jbc.M104165200. PMID 11404359.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Vries T, Yen TY, Joshi RK; et al. (2001). "Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures". Glycobiology. 11 (5): 423–32. PMID 11425803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.CS1 maint: Multiple names: authors list (link)
• Zerfaoui M, Fukuda M, Langlet C; et al. (2002). "The cytosolic and transmembrane domains of the beta 1,6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant". Glycobiology. 12 (1): 15–24. PMID 11825883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hiraiwa N, Yabuta T, Yoritomi K; et al. (2003). "Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element". Blood. 101 (9): 3615–21. doi:10.1182/blood-2002-07-2301. PMID 12506041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zisoulis DG, Kansas GS (2004). "H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells". J. Biol. Chem. 279 (38): 39495–504. doi:10.1074/jbc.M407904200. PMID 15262995.
• Miyashiro M, Furuya S, Fujishige K, Sugita T (2004). "Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII". Biochem. Biophys. Res. Commun. 324 (1): 98–107. doi:10.1016/j.bbrc.2004.09.025. PMID 15464988.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martinez M, Joffraud M, Giraud S; et al. (2005). "Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII". J. Biol. Chem. 280 (7): 5378–90. doi:10.1074/jbc.M410899200. PMID 15579466.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prorok-Hamon M, Notel F, Mathieu S; et al. (2006). "N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding". Biochem. J. 391 (Pt 3): 491–502. doi:10.1042/BJ20050344. PMID 15926890.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brown V, Brown RA, Ozinsky A; et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMID 16482509.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang QY, Zhang Y, Chen HJ; et al. (2007). "Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway". FEBS J. 274 (2): 526–38. doi:10.1111/j.1742-4658.2006.05599.x. PMID 17229154.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)