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{{Underlinked|date=May 2014}}
{{Underlinked|date=May 2014}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Galactoside 2-alpha-L-fucosyltransferase 2''' is an [[enzyme]] that in humans is encoded by the ''FUT2'' [[gene]].<ref name="pmid1763885">{{cite journal |vauthors=Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R | title = The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9 | journal = Ann Hum Genet | volume = 55 | issue = Pt 3 | pages = 225–33 |date=Feb 1992 | pmid = 1763885 | pmc =  | doi =10.1111/j.1469-1809.1991.tb00417.x  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2524| accessdate = }}</ref> It affects the [[Lewis antigen system|Lewis blood group]].{{cn|date=April 2017}}


Approximately 20% of Caucasians are [[non-secretor]]s due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the [[norovirus]] GII.4.{{cn|date=April 2017}}
'''Galactoside 2-alpha-L-fucosyltransferase 2''' is an [[enzyme]] that in humans is encoded by the ''FUT2'' [[gene]].<ref name="pmid1763885">{{cite journal |vauthors=Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R | title = The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9 | journal = Ann Hum Genet | volume = 55 | issue = Pt 3 | pages = 225–33 |date=Feb 1992 | pmid = 1763885 | pmc = | doi =10.1111/j.1469-1809.1991.tb00417.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2524| accessdate = }}</ref> It affects the [[Lewis antigen system|Lewis blood group]].{{citation needed|date=April 2017}}
 
Approximately 20% of Caucasians are [[non-secretor]]s due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the [[norovirus]] GII.4.{{citation needed|date=April 2017}}


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==References==
==References==
{{reflist}}
{{Reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Reguigne-Arnould I |title=Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19 |journal=Cytogenet. Cell Genet. |volume=71 |issue= 2 |pages= 158–62 |year= 1995 |pmid= 7656588 |doi=10.1159/000134098 | author2=Couillin P | author3=Mollicone R | display-authors=3 | last4=Faur&Eacute; | first4=S. | last5=Fletcher | first5=A. | last6=Kelly | first6=R.J. | last7=Lowe | first7=J.B. | last8=Oriol | first8=R. }}
*{{cite journal | author=Reguigne-Arnould I |title=Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19 |journal=Cytogenet. Cell Genet. |volume=71 |issue= 2 |pages= 158–62 |year= 1995 |pmid= 7656588 |doi=10.1159/000134098 | author2=Couillin P | author3=Mollicone R | display-authors=3 | last4=Faur&Eacute; | first4=S. | last5=Fletcher | first5=A. | last6=Kelly | first6=R.J. | last7=Lowe | first7=J.B. | last8=Oriol | first8=R. }}
*{{cite journal | author=Rouquier S |title=Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4632–9 |year= 1995 |pmid= 7876234 |doi=10.1074/jbc.270.9.4632 | author2=Lowe JB | author3=Kelly RJ | display-authors=3 | last4=Fertitta | first4=AL | last5=Lennon | first5=GG | last6=Giorgi | first6=D }}
*{{cite journal | author=Rouquier S |title=Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4632–9 |year= 1995 |pmid= 7876234 |doi=10.1074/jbc.270.9.4632 | author2=Lowe JB | author3=Kelly RJ | display-authors=3 | last4=Fertitta | first4=AL | last5=Lennon | first5=GG | last6=Giorgi | first6=D }}
*{{cite journal | author=Kelly RJ |title=Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4640–9 |year= 1995 |pmid= 7876235 |doi= 10.1074/jbc.270.9.4640| author2=Rouquier S | author3=Giorgi D | display-authors=3 | last4=Lennon | first4=GG | last5=Lowe | first5=JB }}
*{{cite journal | author=Kelly RJ |title=Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4640–9 |year= 1995 |pmid= 7876235 |doi= 10.1074/jbc.270.9.4640| author2=Rouquier S | author3=Giorgi D | display-authors=3 | last4=Lennon | first4=GG | last5=Lowe | first5=JB }}
*{{cite journal | author=Kudo T |title=Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals |journal=J. Biol. Chem. |volume=271 |issue= 16 |pages= 9830–7 |year= 1996 |pmid= 8621666 |doi= 10.1074/jbc.271.16.9830| author2=Iwasaki H | author3=Nishihara S | display-authors=3 | last4=Shinya | first4=N | last5=Ando | first5=T | last6=Narimatsu | first6=I | last7=Narimatsu | first7=H }}
*{{cite journal | author=Kudo T |title=Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals |journal=J. Biol. Chem. |volume=271 |issue= 16 |pages= 9830–7 |year= 1996 |pmid= 8621666 |doi= 10.1074/jbc.271.16.9830| author2=Iwasaki H | author3=Nishihara S | display-authors=3 | last4=Shinya | first4=N | last5=Ando | first5=T | last6=Narimatsu | first6=I | last7=Narimatsu | first7=H }}
*{{cite journal |vauthors=Koda Y, Soejima M, Liu Y, Kimura H |title=Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency |journal=Am. J. Hum. Genet. |volume=59 |issue= 2 |pages= 343–50 |year= 1996 |pmid= 8755920 |doi= | pmc=1914724 }}
*{{cite journal |vauthors=Koda Y, Soejima M, Liu Y, Kimura H |title=Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency |journal=Am. J. Hum. Genet. |volume=59 |issue= 2 |pages= 343–50 |year= 1996 |pmid= 8755920 |doi= | pmc=1914724 }}
*{{cite journal |vauthors=Koda Y, Soejima M, Wang B, Kimura H |title=Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2) |journal=Eur. J. Biochem. |volume=246 |issue= 3 |pages= 750–5 |year= 1997 |pmid= 9219535 |doi=10.1111/j.1432-1033.1997.t01-1-00750.x }}
*{{cite journal |vauthors=Koda Y, Soejima M, Wang B, Kimura H |title=Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2) |journal=Eur. J. Biochem. |volume=246 |issue= 3 |pages= 750–5 |year= 1997 |pmid= 9219535 |doi=10.1111/j.1432-1033.1997.t01-1-00750.x }}
*{{cite journal | author=Koda Y |title=Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 1 |pages= 21–5 |year= 1997 |pmid= 9299444 |doi= 10.1006/bbrc.1997.7232 | author2=Soejima M | author3=Johnson PH | display-authors=3 | last4=Smart | first4=E | last5=Kimura | first5=H }}
*{{cite journal | author=Koda Y |title=Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 1 |pages= 21–5 |year= 1997 |pmid= 9299444 |doi= 10.1006/bbrc.1997.7232 | author2=Soejima M | author3=Johnson PH | display-authors=3 | last4=Smart | first4=E | last5=Kimura | first5=H }}
*{{cite journal | author=Liu Y |title=Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa |journal=Hum. Genet. |volume=103 |issue= 2 |pages= 204–10 |year= 1998 |pmid= 9760207 |doi=10.1007/s004390050808 | author2=Koda Y | author3=Soejima M | display-authors=3 | last4=Pang | first4=H. | last5=Schlaphoff | first5=Terry | last6=Du Toit | first6=Ernette D. | last7=Kimura | first7=H. }}
*{{cite journal | author=Liu Y |title=Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa |journal=Hum. Genet. |volume=103 |issue= 2 |pages= 204–10 |year= 1998 |pmid= 9760207 |doi=10.1007/s004390050808 | author2=Koda Y | author3=Soejima M | display-authors=3 | last4=Pang | first4=H. | last5=Schlaphoff | first5=Terry | last6=Du Toit | first6=Ernette D. | last7=Kimura | first7=H. }}
*{{cite journal |vauthors=Domino SE, Zhang L, Lowe JB |title=Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23748–56 |year= 2001 |pmid= 11323419 |doi= 10.1074/jbc.M100735200 }}
*{{cite journal |vauthors=Domino SE, Zhang L, Lowe JB |title=Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23748–56 |year= 2001 |pmid= 11323419 |doi= 10.1074/jbc.M100735200 }}
*{{cite journal |vauthors=Roos C, Kolmer M, Mattila P, Renkonen R |title=Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3168–75 |year= 2002 |pmid= 11698403 |doi= 10.1074/jbc.M107927200 }}
*{{cite journal |vauthors=Roos C, Kolmer M, Mattila P, Renkonen R |title=Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3168–75 |year= 2002 |pmid= 11698403 |doi= 10.1074/jbc.M107927200 }}
*{{cite journal | author=Milland J |title=The cytoplasmic tail of alpha 1,3-galactosyltransferase inhibits Golgi localization of the full-length enzyme |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10374–8 |year= 2002 |pmid= 11777923 |doi= 10.1074/jbc.M111799200 | author2=Russell SM | author3=Dodson HC | display-authors=3 | last4=McKenzie | first4=IF | last5=Sandrin | first5=MS }}
*{{cite journal | author=Milland J |title=The cytoplasmic tail of alpha 1,3-galactosyltransferase inhibits Golgi localization of the full-length enzyme |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10374–8 |year= 2002 |pmid= 11777923 |doi= 10.1074/jbc.M111799200 | author2=Russell SM | author3=Dodson HC | display-authors=3 | last4=McKenzie | first4=IF | last5=Sandrin | first5=MS }}
*{{cite journal | author=Chang JG |title=Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation |journal=J. Hum. Genet. |volume=47 |issue= 2 |pages= 60–5 |year= 2002 |pmid= 11916003 |doi=10.1007/s100380200001 | author2=Ko YC | author3=Lee JC | display-authors=3 | last4=Chang | first4=S.-J. | last5=Liu | first5=T.-C. | last6=Shih | first6=M.-C. | last7=Peng | first7=C.-T. }}
*{{cite journal | author=Chang JG |title=Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation |journal=J. Hum. Genet. |volume=47 |issue= 2 |pages= 60–5 |year= 2002 |pmid= 11916003 |doi=10.1007/s100380200001 | author2=Ko YC | author3=Lee JC | display-authors=3 | last4=Chang | first4=S.-J. | last5=Liu | first5=T.-C. | last6=Shih | first6=M.-C. | last7=Peng | first7=C.-T. }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
*{{cite journal | author=Lindesmith L |title=Human susceptibility and resistance to Norwalk virus infection |journal=Nat. Med. |volume=9 |issue= 5 |pages= 548–53 |year= 2003 |pmid= 12692541 |doi= 10.1038/nm860 | author2=Moe C | author3=Marionneau S | display-authors=3 | last4=Ruvoen | first4=Nathalie | last5=Jiang | first5=Xi | last6=Lindblad | first6=Lauren | last7=Stewart | first7=Paul | last8=Lependu | first8=Jacques | last9=Baric | first9=Ralph }}
*{{cite journal | author=Lindesmith L |title=Human susceptibility and resistance to Norwalk virus infection |journal=Nat. Med. |volume=9 |issue= 5 |pages= 548–53 |year= 2003 |pmid= 12692541 |doi= 10.1038/nm860 | author2=Moe C | author3=Marionneau S | display-authors=3 | last4=Ruvoen | first4=Nathalie | last5=Jiang | first5=Xi | last6=Lindblad | first6=Lauren | last7=Stewart | first7=Paul | last8=Lependu | first8=Jacques | last9=Baric | first9=Ralph }}
*{{cite journal | author=Guo ZH |title=[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=21 |issue= 5 |pages= 417–21 |year= 2004|pmid= 15476160 |doi= | author2=Xiang D | author3=Zhu ZY | display-authors=3 | last4=Wang | first4=JL | last5=Zhang | first5=JM | last6=Liu | first6=X | last7=Shen | first7=W | last8=Chen | first8=HP }}
*{{cite journal | author=Guo ZH |title=[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=21 |issue= 5 |pages= 417–21 |year= 2004|pmid= 15476160 |doi= | author2=Xiang D | author3=Zhu ZY | display-authors=3 | last4=Wang | first4=JL | last5=Zhang | first5=JM | last6=Liu | first6=X | last7=Shen | first7=W | last8=Chen | first8=HP }}
*{{cite journal | author=Chen DP |title=Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese |journal=Ann. Clin. Lab. Sci. |volume=34 |issue= 3 |pages= 314–8 |year= 2005 |pmid= 15487706 |doi= | author2=Tseng CP | author3=Wang WT | display-authors=3 | last4=Peng | first4=CT | last5=Tsao | first5=KC | last6=Wu | first6=TL | last7=Lin | first7=KT | last8=Sun | first8=CF }}
*{{cite journal | author=Chen DP |title=Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese |journal=Ann. Clin. Lab. Sci. |volume=34 |issue= 3 |pages= 314–8 |year= 2005 |pmid= 15487706 |doi= | author2=Tseng CP | author3=Wang WT | display-authors=3 | last4=Peng | first4=CT | last5=Tsao | first5=KC | last6=Wu | first6=TL | last7=Lin | first7=KT | last8=Sun | first8=CF }}
*{{cite journal |vauthors=Pang H, Soejima M, Koda Y, Kimura H |title=A novel tetrameric short tandem repeat located in the 3' flanking region of the human ABO-secretor gene (FUT2) and association between FUT2 and FUT2/01 loci |journal=Hum. Biol. |volume=76 |issue= 5 |pages= 789–95 |year= 2005 |pmid= 15757249 |doi=10.1353/hub.2005.0008 }}
*{{cite journal |vauthors=Pang H, Soejima M, Koda Y, Kimura H |title=A novel tetrameric short tandem repeat located in the 3' flanking region of the human ABO-secretor gene (FUT2) and association between FUT2 and FUT2/01 loci |journal=Hum. Biol. |volume=76 |issue= 5 |pages= 789–95 |year= 2005 |pmid= 15757249 |doi=10.1353/hub.2005.0008 }}
*{{cite journal | author=Madjd Z |title=High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas |journal=Breast Cancer Res. |volume=7 |issue= 5 |pages= R780–7 |year= 2006 |pmid= 16168124 |doi= 10.1186/bcr1305 | pmc=1242157 | author2=Parsons T | author3=Watson NF | display-authors=3 | last4=Spendlove | first4=Ian | last5=Ellis | first5=Ian | last6=Durrant | first6=Lindy G }}
*{{cite journal | author=Madjd Z |title=High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas |journal=Breast Cancer Res. |volume=7 |issue= 5 |pages= R780–7 |year= 2006 |pmid= 16168124 |doi= 10.1186/bcr1305 | pmc=1242157 | author2=Parsons T | author3=Watson NF | display-authors=3 | last4=Spendlove | first4=Ian | last5=Ellis | first5=Ian | last6=Durrant | first6=Lindy G }}
*{{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 | author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
*{{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 | author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
}}
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Latest revision as of 14:05, 10 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene.[1][2] It affects the Lewis blood group.[citation needed]

Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.[citation needed]


References

  1. ↑ Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885.
  2. ↑ "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)".

Further reading



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