FRS3

Fibroblast growth factor receptor substrate 3
Identifiers
Symbols	FRS3 ; SNT2; FRS2B; FRS2beta; MGC17167; SNT-2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4845
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fibroblast growth factor receptor substrate 3, also known as FRS3, is a human gene.

The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.

Further reading

• Wang JK, Xu H, Li HC, Goldfarb M (1996). "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene. 13 (4): 721–9. PMID 8761293.CS1 maint: Multiple names: authors list (link)
• Xu H, Lee KW, Goldfarb M (1998). "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". J. Biol. Chem. 273 (29): 17987–90. PMID 9660748.CS1 maint: Multiple names: authors list (link)
• Lim YP, Low BC, Lim J; et al. (1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". J. Biol. Chem. 274 (27): 19025–34. PMID 10383403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ong SH, Guy GR, Hadari YR; et al. (2000). "FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors". Mol. Cell. Biol. 20 (3): 979–89. PMID 10629055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamada M, Suzuki K, Mizutani M; et al. (2001). "Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system". J. Biochem. 130 (1): 157–65. PMID 11432792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan KS, Kuti M, Yan S; et al. (2002). "FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors". J. Biol. Chem. 277 (19): 17088–94. doi:10.1074/jbc.M107963200. PMID 11877385.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ranzi V, Meakin SO, Miranda C; et al. (2003). "The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins". Endocrinology. 144 (3): 922–8. PMID 12586769.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gotoh N, Laks S, Nakashima M; et al. (2004). "FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts". FEBS Lett. 564 (1–2): 14–8. doi:10.1016/S0014-5793(04)00287-X. PMID 15094036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hassel S, Eichner A, Yakymovych M; et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang L, Gotoh N, Zhang S; et al. (2004). "SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation". Biochem. Biophys. Res. Commun. 324 (3): 1011–7. doi:10.1016/j.bbrc.2004.09.152. PMID 15485655.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada A, Katoh H, Negishi M (2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells". J. Biol. Chem. 280 (18): 18418–24. doi:10.1074/jbc.M411356200. PMID 15738000.CS1 maint: Multiple names: authors list (link)
• Huang L, Watanabe M, Chikamori M; et al. (2006). "Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways". Oncogene. 25 (49): 6457–66. doi:10.1038/sj.onc.1209656. PMID 16702953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)