FRS3: Difference between revisions

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{{Infobox_gene}}
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'''Fibroblast growth factor receptor substrate 3''' is a [[protein]] that in humans is encoded by the ''FRS3'' [[gene]].<ref name="pmid8761293">{{cite journal |vauthors=Wang JK, Xu H, Li HC, Goldfarb M | title = Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras | journal = Oncogene | volume = 13 | issue = 4 | pages = 721–9 |date=Oct 1996 | pmid = 8761293 | pmc = | doi =  }}</ref><ref name="pmid9660748">{{cite journal |vauthors=Xu H, Lee KW, Goldfarb M | title = Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins | journal = J Biol Chem | volume = 273 | issue = 29 | pages = 17987–90 |date=Aug 1998 | pmid = 9660748 | pmc = | doi =10.1074/jbc.273.29.17987 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10817| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Fibroblast growth factor receptor substrate 3
| HGNCid = 16970
| Symbol = FRS3
| AltSymbols =; SNT2; FRS2B; FRS2beta; MGC17167; SNT-2
| OMIM = 607744
| ECnumber =
| Homologene = 4845
| MGIid = 2135965
| GeneAtlas_image1 = PBB_GE_FRS3_219907_at_tn.png
| Function = {{GNF_GO|id=GO:0005158 |text = insulin receptor binding}}
  | Component = {{GNF_GO|id=GO:0016020 |text = membrane}}  
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008543 |text = fibroblast growth factor receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10817
    | Hs_Ensembl = ENSG00000137218
    | Hs_RefseqProtein = NP_006644
    | Hs_RefseqmRNA = NM_006653
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 41845892
    | Hs_GenLoc_end = 41855616
    | Hs_Uniprot = O43559
    | Mm_EntrezGene = 107971
    | Mm_Ensembl = ENSMUSG00000023266
    | Mm_RefseqmRNA = NM_144939
    | Mm_RefseqProtein = NP_659188
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 47160378
    | Mm_GenLoc_end = 47167477
    | Mm_Uniprot = Q91WJ0
  }}
}}
'''Fibroblast growth factor receptor substrate 3''', also known as '''FRS3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10817| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.<ref name="entrez">{{cite web | title = Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10817| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.<ref name="entrez">{{cite web | title = Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10817| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wang JK, Xu H, Li HC, Goldfarb M |title=Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras. |journal=Oncogene |volume=13 |issue= 4 |pages= 721-9 |year= 1996 |pmid= 8761293 |doi=  }}
*{{cite journal  |vauthors=Lim YP, Low BC, Lim J |title=Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19025–34 |year= 1999 |pmid= 10383403 |doi=10.1074/jbc.274.27.19025 |display-authors=etal}}
*{{cite journal  | author=Xu H, Lee KW, Goldfarb M |title=Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 17987-90 |year= 1998 |pmid= 9660748 |doi=  }}
*{{cite journal  |vauthors=Ong SH, Guy GR, Hadari YR |title=FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 979–89 |year= 2000 |pmid= 10629055 |doi=10.1128/MCB.20.3.979-989.2000 | pmc=85215  |display-authors=etal}}
*{{cite journal  | author=Lim YP, Low BC, Lim J, ''et al.'' |title=Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19025-34 |year= 1999 |pmid= 10383403 |doi=  }}
*{{cite journal  |vauthors=Yamada M, Suzuki K, Mizutani M |title=Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system. |journal=J. Biochem. |volume=130 |issue= 1 |pages= 157–65 |year= 2001 |pmid= 11432792 |doi=  10.1093/oxfordjournals.jbchem.a002955|display-authors=etal}}
*{{cite journal  | author=Ong SH, Guy GR, Hadari YR, ''et al.'' |title=FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 979-89 |year= 2000 |pmid= 10629055 |doi=  }}
*{{cite journal  |vauthors=Yan KS, Kuti M, Yan S |title=FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 17088–94 |year= 2002 |pmid= 11877385 |doi= 10.1074/jbc.M107963200 |display-authors=etal}}
*{{cite journal  | author=Yamada M, Suzuki K, Mizutani M, ''et al.'' |title=Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system. |journal=J. Biochem. |volume=130 |issue= 1 |pages= 157-65 |year= 2001 |pmid= 11432792 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Yan KS, Kuti M, Yan S, ''et al.'' |title=FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 17088-94 |year= 2002 |pmid= 11877385 |doi= 10.1074/jbc.M107963200 }}
*{{cite journal  |vauthors=Ranzi V, Meakin SO, Miranda C |title=The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins. |journal=Endocrinology |volume=144 |issue= 3 |pages= 922–8 |year= 2003 |pmid= 12586769 |doi=10.1210/en.2002-221002 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
*{{cite journal  | author=Ranzi V, Meakin SO, Miranda C, ''et al.'' |title=The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins. |journal=Endocrinology |volume=144 |issue= 3 |pages= 922-8 |year= 2003 |pmid= 12586769 |doi=  }}
*{{cite journal  |vauthors=Gotoh N, Laks S, Nakashima M |title=FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. |journal=FEBS Lett. |volume=564 |issue= 1-2 |pages= 14–8 |year= 2004 |pmid= 15094036 |doi= 10.1016/S0014-5793(04)00287-X |display-authors=etal}}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  |vauthors=Hassel S, Eichner A, Yakymovych M |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346–58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770 |display-authors=etal}}
*{{cite journal  | author=Gotoh N, Laks S, Nakashima M, ''et al.'' |title=FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. |journal=FEBS Lett. |volume=564 |issue= 1-2 |pages= 14-8 |year= 2004 |pmid= 15094036 |doi= 10.1016/S0014-5793(04)00287-X }}
*{{cite journal  |vauthors=Huang L, Gotoh N, Zhang S |title=SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 3 |pages= 1011–7 |year= 2004 |pmid= 15485655 |doi= 10.1016/j.bbrc.2004.09.152 |display-authors=etal}}
*{{cite journal  | author=Hassel S, Eichner A, Yakymovych M, ''et al.'' |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346-58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Huang L, Gotoh N, Zhang S, ''et al.'' |title=SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 3 |pages= 1011-7 |year= 2004 |pmid= 15485655 |doi= 10.1016/j.bbrc.2004.09.152 }}
*{{cite journal  |vauthors=Harada A, Katoh H, Negishi M |title=Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18418–24 |year= 2005 |pmid= 15738000 |doi= 10.1074/jbc.M411356200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Huang L, Watanabe M, Chikamori M |title=Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. |journal=Oncogene |volume=25 |issue= 49 |pages= 6457–66 |year= 2006 |pmid= 16702953 |doi= 10.1038/sj.onc.1209656 |display-authors=etal}}
*{{cite journal  | author=Harada A, Katoh H, Negishi M |title=Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18418-24 |year= 2005 |pmid= 15738000 |doi= 10.1074/jbc.M411356200 }}
*{{cite journal  | author=Huang L, Watanabe M, Chikamori M, ''et al.'' |title=Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways. |journal=Oncogene |volume=25 |issue= 49 |pages= 6457-66 |year= 2006 |pmid= 16702953 |doi= 10.1038/sj.onc.1209656 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 04:57, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.[1][2][3]

The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.[3]

References

  1. ↑ Wang JK, Xu H, Li HC, Goldfarb M (Oct 1996). "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene. 13 (4): 721–9. PMID 8761293.
  2. ↑ Xu H, Lee KW, Goldfarb M (Aug 1998). "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". J Biol Chem. 273 (29): 17987–90. doi:10.1074/jbc.273.29.17987. PMID 9660748.
  3. ↑ 3.0 3.1 "Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3".

Further reading



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