FLNC (gene)

Filamin C, gamma (actin binding protein 280)
PDB rendering based on 1v05.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1v05​, 2brq​, 2d7m​, 2d7n​, 2d7o​, 2d7p​, 2d7q​
Identifiers
Symbols	FLNC ; ABP-280; ABP280A; ABPA; ABPL; FLJ10186; FLN2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37481
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Filamin C, gamma (actin binding protein 280), also known as FLNC, is a human gene.

This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain.

Further reading

• Stossel TP, Condeelis J, Cooley L; et al. (2001). "Filamins as integrators of cell mechanics and signalling". Nat. Rev. Mol. Cell Biol. 2 (2): 138–45. doi:10.1038/35052082. PMID 11252955.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maestrini E, Patrosso C, Mancini M; et al. (1993). "Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7". Hum. Mol. Genet. 2 (6): 761–6. PMID 7689010.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gariboldi M, Maestrini E, Canzian F; et al. (1994). "Comparative mapping of the actin-binding protein 280 genes in human and mouse". Genomics. 21 (2): 428–30. PMID 8088838.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lanfranchi G, Muraro T, Caldara F; et al. (1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Res. 6 (1): 35–42. PMID 8681137.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marti A, Luo Z, Cunningham C; et al. (1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. 272 (5): 2620–8. PMID 9006895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu G, Thomas L, Warren RA; et al. (1998). "Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway". J. Cell Biol. 139 (7): 1719–33. PMID 9412467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu W, Xie Z, Chung DW, Davie EW (1998). "A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha". Blood. 92 (4): 1268–76. PMID 9694715.CS1 maint: Multiple names: authors list (link)
• Xie Z, Xu W, Davie EW, Chung DW (1998). "Molecular cloning of human ABPL, an actin-binding protein homologue". Biochem. Biophys. Res. Commun. 251 (3): 914–9. PMID 9791010.CS1 maint: Multiple names: authors list (link)
• Thompson TG, Chan YM, Hack AA; et al. (2000). "Filamin 2 (FLN2): A muscle-specific sarcoglycan interacting protein". J. Cell Biol. 148 (1): 115–26. PMID 10629222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van der Ven PF, Obermann WM, Lemke B; et al. (2000). "Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation". Cell Motil. Cytoskeleton. 45 (2): 149–62. doi:10.1002/(SICI)1097-0169(200002)45:2<149::AID-CM6>3.0.CO;2-G. PMID 10658210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Faulkner G, Pallavicini A, Comelli A; et al. (2001). "FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle". J. Biol. Chem. 275 (52): 41234–42. doi:10.1074/jbc.M007493200. PMID 10984498.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van der Ven PF, Wiesner S, Salmikangas P; et al. (2000). "Indications for a novel muscular dystrophy pathway. gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin". J. Cell Biol. 151 (2): 235–48. PMID 11038172.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petrecca K, Miller DM, Shrier A (2001). "Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin". J. Neurosci. 20 (23): 8736–44. PMID 11102480.CS1 maint: Multiple names: authors list (link)
• Chakarova C, Wehnert MS, Uhl K; et al. (2001). "Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family". Hum. Genet. 107 (6): 597–611. PMID 11153914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takada F, Vander Woude DL, Tong HQ; et al. (2001). "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1595–600. doi:10.1073/pnas.041609698. PMID 11171996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dyson JM, O'Malley CJ, Becanovic J; et al. (2002). "The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin". J. Cell Biol. 155 (6): 1065–79. doi:10.1083/jcb.200104005. PMID 11739414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frey N, Olson EN (2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. PMID 11842093.
• Donaldson JC, Dise RS, Ritchie MD, Hanks SK (2002). "Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity". J. Biol. Chem. 277 (32): 29028–35. doi:10.1074/jbc.M111697200. PMID 12006559.CS1 maint: Multiple names: authors list (link)
• Shoeman RL, Hartig R, Hauses C, Traub P (2003). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease". Cell Biol. Int. 26 (6): 529–39. PMID 12119179.CS1 maint: Multiple names: authors list (link)