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{{Infobox_gene}}
{{PBB_Controls
'''FK506 binding protein 5''', also known as '''FKBP5''', is a [[protein]] which in humans is encoded by the ''FKBP5'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FKBP5 FK506 binding protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2289| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_FKBP5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kt0.
| PDB = {{PDB2|1kt0}}, {{PDB2|1kt1}}
| Name = FK506 binding protein 5
| HGNCid = 3721
| Symbol = FKBP5
| AltSymbols =; P54; PPIase; FKBP51; FKBP54; MGC111006; Ptg-10
| OMIM = 602623
| ECnumber = 
| Homologene = 3038
| MGIid = 104670
| GeneAtlas_image1 = PBB_GE_FKBP5_204560_at_tn.png
| Function = {{GNF_GO|id=GO:0003755 |text = peptidyl-prolyl cis-trans isomerase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005528 |text = FK506 binding}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2289
    | Hs_Ensembl = ENSG00000096060
    | Hs_RefseqProtein = NP_004108
    | Hs_RefseqmRNA = NM_004117
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 35649345
    | Hs_GenLoc_end = 35804338
    | Hs_Uniprot = Q13451
    | Mm_EntrezGene = 14229
    | Mm_Ensembl = ENSMUSG00000024222
    | Mm_RefseqmRNA = NM_010220
    | Mm_RefseqProtein = NP_034350
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 28126686
    | Mm_GenLoc_end = 28213738
    | Mm_Uniprot = Q3TX72
  }}
}}
'''FK506 binding protein 5''', also known as '''FKBP5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FKBP5 FK506 binding protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2289| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the [[Immunophilins|immunophilin protein family]], which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature corticoid receptor hetero-complexes  (i.e. progesterone-, glucocorticoid-, mineralocorticoid-receptor complexes) along with the 90 kDa heat shock protein and P23 protein.
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites.<ref name="entrez">{{cite web | title = Entrez Gene: FKBP5 FK506 binding protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2289| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
The FKBP5 gene has been found to have multiple [[polyadenylation]] sites<ref name="entrez"/> and is statistically associated with a higher rate of depressive disorders.<ref name="pmid15565110">{{cite journal | vauthors = Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Pütz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Künzel HE, Fuchs B, Majer M, Pfennig A, Kern N, Brunner J, Modell S, Baghai T, Deiml T, Zill P, Bondy B, Rupprecht R, Messer T, Köhnlein O, Dabitz H, Brückl T, Müller N, Pfister H, Lieb R, Mueller JC, Lõhmussaar E, Strom TM, Bettecken T, Meitinger T, Uhr M, Rein T, Holsboer F, Muller-Myhsok B | title = Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment | journal = Nat. Genet. | volume = 36 | issue = 12 | pages = 1319–25  | date = December 2004 | pmid = 15565110 | doi = 10.1038/ng1479 }}</ref>
==Further reading==
 
== Interactions ==
 
FKBP5 has been shown to [[Protein-protein interaction|interact]] with [[Heat shock protein 90kDa alpha (cytosolic), member A1]].<ref name=pmid9001212>{{cite journal | vauthors = Nair SC, Rimerman RA, Toran EJ, Chen S, Prapapanich V, Butts RN, Smith DF | title = Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor | journal = Mol. Cell. Biol. | volume = 17 | issue = 2 | pages = 594–603  | date = Feb 1997 | pmid = 9001212 | pmc = 231784 }}</ref>
 
== See also ==
* [[FKBP52| FKBP52 - a functional antagonist to FKBP51 at corticoid receptors]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Schiene-Fischer C, Yu C | title = Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases | journal = FEBS Lett. | volume = 495 | issue = 1-2 | pages = 1–6 | year = 2001 | pmid = 11322937 | doi = 10.1016/S0014-5793(01)02326-2 | url = http://onlinelibrary.wiley.com/doi/10.1016/S0014-5793(01)02326-2/pdf }}
| citations =
* {{cite journal | vauthors = Baughman G, Wiederrecht GJ, Campbell NF, Martin MM, Bourgeois S | title = FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition | journal = Mol. Cell. Biol. | volume = 15 | issue = 8 | pages = 4395–402 | year = 1995 | pmid = 7542743 | pmc = 230679 | doi =  10.1128/mcb.15.8.4395}}
*{{cite journal | author=Schiene-Fischer C, Yu C |title=Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. |journal=FEBS Lett. |volume=495 |issue= 1-2 |pages= 1-6 |year= 2001 |pmid= 11322937 |doi= }}
* {{cite journal | vauthors = Smith DF, Baggenstoss BA, Marion TN, Rimerman RA | title = Two FKBP-related proteins are associated with progesterone receptor complexes | journal = J. Biol. Chem. | volume = 268 | issue = 24 | pages = 18365–71 | year = 1993 | pmid = 7688746 | doi =  }}
*{{cite journal | author=Baughman G, Wiederrecht GJ, Campbell NF, ''et al.'' |title=FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition. |journal=Mol. Cell. Biol. |volume=15 |issue= 8 |pages= 4395-402 |year= 1995 |pmid= 7542743 |doi=  }}
* {{cite journal | vauthors = Smith DF, Albers MW, Schreiber SL, Leach KL, Deibel MR | title = FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts | journal = J. Biol. Chem. | volume = 268 | issue = 32 | pages = 24270–3 | year = 1993 | pmid = 7693698 | doi =  }}
*{{cite journal | author=Smith DF, Baggenstoss BA, Marion TN, Rimerman RA |title=Two FKBP-related proteins are associated with progesterone receptor complexes. |journal=J. Biol. Chem. |volume=268 |issue= 24 |pages= 18365-71 |year= 1993 |pmid= 7688746 |doi=  }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Smith DF, Albers MW, Schreiber SL, ''et al.'' |title=FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 24270-3 |year= 1993 |pmid= 7693698 |doi=  }}
* {{cite journal | vauthors = Johnson J, Corbisier R, Stensgard B, Toft D | title = The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes | journal = J. Steroid Biochem. Mol. Biol. | volume = 56 | issue = 1-6 Spec No | pages = 31–7 | year = 1996 | pmid = 8603045 | doi = 10.1016/0960-0760(95)00221-9 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Nair SC, Rimerman RA, Toran EJ, Chen S, Prapapanich V, Butts RN, Smith DF | title = Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor | journal = Mol. Cell. Biol. | volume = 17 | issue = 2 | pages = 594–603 | year = 1997 | pmid = 9001212 | pmc = 231784 | doi =  }}
*{{cite journal | author=Johnson J, Corbisier R, Stensgard B, Toft D |title=The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes. |journal=J. Steroid Biochem. Mol. Biol. |volume=56 |issue= 1-6 Spec No |pages= 31-7 |year= 1996 |pmid= 8603045 |doi= }}
* {{cite journal | vauthors = Baughman G, Wiederrecht GJ, Chang F, Martin MM, Bourgeois S | title = Tissue distribution and abundance of human FKBP51, and FK506-binding protein that can mediate calcineurin inhibition | journal = Biochem. Biophys. Res. Commun. | volume = 232 | issue = 2 | pages = 437–43 | year = 1997 | pmid = 9125197 | doi = 10.1006/bbrc.1997.6307 }}
*{{cite journal | author=Nair SC, Rimerman RA, Toran EJ, ''et al.'' |title=Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. |journal=Mol. Cell. Biol. |volume=17 |issue= 2 |pages= 594-603 |year= 1997 |pmid= 9001212 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Baughman G, Wiederrecht GJ, Chang F, ''et al.'' |title=Tissue distribution and abundance of human FKBP51, and FK506-binding protein that can mediate calcineurin inhibition. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 2 |pages= 437-43 |year= 1997 |pmid= 9125197 |doi= }}
* {{cite journal | vauthors = Young JC, Obermann WM, Hartl FU | title = Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90 | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18007–10 | year = 1998 | pmid = 9660753 | doi = 10.1074/jbc.273.29.18007 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Young JC, Obermann WM, Hartl FU |title=Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18007-10 |year= 1998 |pmid= 9660753 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Pirkl F, Buchner J | title = Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40 | journal = J. Mol. Biol. | volume = 308 | issue = 4 | pages = 795–806 | year = 2001 | pmid = 11350175 | doi = 10.1006/jmbi.2001.4595 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Davies TH, Ning YM, Sánchez ER | title = A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 4597–600 | year = 2002 | pmid = 11751894 | doi = 10.1074/jbc.C100531200 }}
*{{cite journal | author=Pirkl F, Buchner J |title=Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. |journal=J. Mol. Biol. |volume=308 |issue= 4 |pages= 795-806 |year= 2001 |pmid= 11350175 |doi= 10.1006/jmbi.2001.4595 }}
* {{cite journal | vauthors = Giraudier S, Chagraoui H, Komura E, Barnache S, Blanchet B, LeCouedic JP, Smith DF, Larbret F, Taksin AL, Moreau-Gachelin F, Casadevall N, Tulliez M, Hulin A, Debili N, Vainchenker W | title = Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors | journal = Blood | volume = 100 | issue = 8 | pages = 2932–40 | year = 2002 | pmid = 12351405 | doi = 10.1182/blood-2002-02-0485 }}
*{{cite journal | author=Davies TH, Ning YM, Sánchez ER |title=A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4597-600 |year= 2002 |pmid= 11751894 |doi= 10.1074/jbc.C100531200 }}
* {{cite journal | vauthors = Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J | title = Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 3 | pages = 868–73 | year = 2003 | pmid = 12538866 | pmc = 298693 | doi = 10.1073/pnas.0231020100 }}
*{{cite journal | author=Giraudier S, Chagraoui H, Komura E, ''et al.'' |title=Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors. |journal=Blood |volume=100 |issue= 8 |pages= 2932-40 |year= 2002 |pmid= 12351405 |doi= 10.1182/blood-2002-02-0485 }}
* {{cite journal | vauthors = Hubler TR, Denny WB, Valentine DL, Cheung-Flynn J, Smith DF, Scammell JG | title = The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness | journal = Endocrinology | volume = 144 | issue = 6 | pages = 2380–7 | year = 2003 | pmid = 12746298 | doi = 10.1210/en.2003-0092 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal | author=Sinars CR, Cheung-Flynn J, Rimerman RA, ''et al.'' |title=Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 868-73 |year= 2003 |pmid= 12538866 |doi= 10.1073/pnas.0231020100 }}
*{{cite journal | author=Hubler TR, Denny WB, Valentine DL, ''et al.'' |title=The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness. |journal=Endocrinology |volume=144 |issue= 6 |pages= 2380-7 |year= 2003 |pmid= 12746298 |doi=  }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 23:10, 27 April 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene.[1]

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature corticoid receptor hetero-complexes (i.e. progesterone-, glucocorticoid-, mineralocorticoid-receptor complexes) along with the 90 kDa heat shock protein and P23 protein.

Clinical significance

The FKBP5 gene has been found to have multiple polyadenylation sites[1] and is statistically associated with a higher rate of depressive disorders.[2]

Interactions

FKBP5 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1.[3]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: FKBP5 FK506 binding protein 5".
  2. ↑ Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Pütz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Künzel HE, Fuchs B, Majer M, Pfennig A, Kern N, Brunner J, Modell S, Baghai T, Deiml T, Zill P, Bondy B, Rupprecht R, Messer T, Köhnlein O, Dabitz H, Brückl T, Müller N, Pfister H, Lieb R, Mueller JC, Lõhmussaar E, Strom TM, Bettecken T, Meitinger T, Uhr M, Rein T, Holsboer F, Muller-Myhsok B (December 2004). "Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment". Nat. Genet. 36 (12): 1319–25. doi:10.1038/ng1479. PMID 15565110.
  3. ↑ Nair SC, Rimerman RA, Toran EJ, Chen S, Prapapanich V, Butts RN, Smith DF (Feb 1997). "Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor". Mol. Cell. Biol. 17 (2): 594–603. PMC 231784. PMID 9001212.

Further reading

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