FGR (gene): Difference between revisions

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Revision as of 21:57, 25 November 2017

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.^[1]^[2]

Function

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[2]

Discovery

The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.^[3]

Interactions

FGR (gene) has been shown to interact with Wiskott-Aldrich syndrome protein.^[4]^[5]^[6]

References

↑ Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "of Sciences of the United States of America". 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.
↑ ^2.0 ^2.1 "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog".
↑ Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology. 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.
↑ Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I (Aug 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Current Biology. 6 (8): 981–8. doi:10.1016/S0960-9822(02)00642-5. PMID 8805332.
↑ Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O, Hsuan JJ, Kellie S (Oct 1996). "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". The Journal of Biological Chemistry. 271 (42): 26291–5. doi:10.1074/jbc.271.42.26291. PMID 8824280.
↑ Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC (Oct 1995). "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology. 15 (10): 5725–31. PMC 230823. PMID 7565724.

Patel M, Faulkner L, Katz DR, Brickell PM (1991). "The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages". Pathobiology. 59 (4): 289–92. doi:10.1159/000163665. PMID 1652975.
Resh MD (Feb 1994). "Myristylation and palmitylation of Src family members: the fats of the matter". Cell. 76 (3): 411–3. doi:10.1016/0092-8674(94)90104-X. PMID 8313462.
Lowell CA, Berton G (Mar 1999). "Integrin signal transduction in myeloid leukocytes". Journal of Leukocyte Biology. 65 (3): 313–20. PMID 10080533.
Snapper SB, Rosen FS (1999). "The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization". Annual Review of Immunology. 17 (1): 905–29. doi:10.1146/annurev.immunol.17.1.905. PMID 10358777.
Tatosyan AG, Mizenina OA (Jan 2000). "Kinases of the Src family: structure and functions". Biochemistry. Biokhimii͡A. 65 (1): 49–58. PMID 10702640.
Patel MS, Mankoo BS, Brickell PM (Apr 1992). "A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1". Human Molecular Genetics. 1 (1): 65. doi:10.1093/hmg/1.1.65-a. PMID 1339476.
Link DC, Gutkind SJ, Robbins KC, Ley TJ (May 1992). "Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter". Oncogene. 7 (5): 877–84. PMID 1373875.
Patel M, Leevers SJ, Brickell PM (Feb 1990). "Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites". Oncogene. 5 (2): 201–6. PMID 1690869.
Biondi A, Paganin C, Rossi V, Benvestito S, Perlmutter RM, Mantovani A, Allavena P (Mar 1991). "Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells". European Journal of Immunology. 21 (3): 843–6. doi:10.1002/eji.1830210348. PMID 1826268.
Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC (Mar 1991). "A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes". Molecular and Cellular Biology. 11 (3): 1500–7. PMC 369433. PMID 1847500.
Patel M, Leevers SJ, Brickell PM (Feb 1990). "Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines". International Journal of Cancer. 45 (2): 342–6. doi:10.1002/ijc.2910450222. PMID 2154410.
Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM (Apr 1985). "Isolation of duplicated human c-src genes located on chromosomes 1 and 20". Molecular and Cellular Biology. 5 (4): 831–8. PMC 366788. PMID 2581127.
Brickell PM, Patel M (Dec 1988). "Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines". British Journal of Cancer. 58 (6): 704–9. doi:10.1038/bjc.1988.294. PMC 2246855. PMID 2852026.
Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proceedings of the National Academy of Sciences of the United States of America. 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.
Cheah MS, Ley TJ, Tronick SR, Robbins KC (1986). "fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection". Nature. 319 (6050): 238–40. doi:10.1038/319238a0. PMID 3003578.
Nishizawa M, Semba K, Yoshida MC, Yamamoto T, Sasaki M, Toyoshima K (Feb 1986). "Structure, expression, and chromosomal location of the human c-fgr gene". Molecular and Cellular Biology. 6 (2): 511–7. PMC 367540. PMID 3023853.
Katamine S, Notario V, Rao CD, Miki T, Cheah MS, Tronick SR, Robbins KC (Jan 1988). "Primary structure of the human fgr proto-oncogene product p55c-fgr". Molecular and Cellular Biology. 8 (1): 259–66. PMC 363113. PMID 3275868.
Inoue K, Ikawa S, Semba K, Sukegawa J, Yamamoto T, Toyoshima K (1988). "Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9". Oncogene. 1 (3): 301–4. PMID 3330776.
Nishizawa M, Semba K, Yamamoto T, Toyoshima K (Mar 1985). "Human c-f gr gene does not contain coding sequence for actin-like protein". Japanese Journal of Cancer Research. 76 (3): 155–9. PMID 3922831.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid2995972-1] Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "of Sciences of the United States of America". 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.

[entrez-2] 2.0 ^2.1 "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog".

[pmid6175084-3] Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology. 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.

[pmid8805332-4] Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I (Aug 1996). "Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases". Current Biology. 6 (8): 981–8. doi:10.1016/S0960-9822(02)00642-5. PMID 8805332.

[pmid8824280-5] Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O, Hsuan JJ, Kellie S (Oct 1996). "Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains". The Journal of Biological Chemistry. 271 (42): 26291–5. doi:10.1074/jbc.271.42.26291. PMID 8824280.

[pmid7565724-6] Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC (Oct 1995). "Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains". Molecular and Cellular Biology. 15 (10): 5725–31. PMC 230823. PMID 7565724.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog''', also known as '''FGR''', is a [[protein]] which in humans is encoded by the ''FGR'' [[gene]].<ref name="pmid2995972">{{cite journal | vauthors = Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC | title =  of Sciences of the United States of America | volume = 82 | issue = 19 | pages = 6595–9 | date = Oct 1985 | pmid = 2995972 | pmc = 391256 | doi = 10.1073/pnas.82.19.6595 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2268| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
- | HGNCid = 3697
- | Symbol = FGR
- | AltSymbols =; FLJ43153; MGC75096; SRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr
- | OMIM = 164940
- | ECnumber =
- | Homologene = 3842
- | MGIid = 95527
- | GeneAtlas_image1 = PBB_GE_FGR_208438_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component =
- | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 2268
-    | Hs_Ensembl = ENSG00000000938
-    | Hs_RefseqProtein = NP_001036194
-    | Hs_RefseqmRNA = NM_001042729
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 27811162
-    | Hs_GenLoc_end = 27834375
-    | Hs_Uniprot = P09769
-    | Mm_EntrezGene = 14191
-    | Mm_Ensembl = ENSMUSG00000028874
-    | Mm_RefseqmRNA = NM_010208
-    | Mm_RefseqProtein = NP_034338
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 4
-    | Mm_GenLoc_start = 132246266
-    | Mm_GenLoc_end = 132273953
-    | Mm_Uniprot = Q6GTF2
-  }}
-}}
-'''Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog''', also known as '''FGR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2268| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This gene is a member of the Src family of protein [[tyrosine kinase]]s (PTKs). The encoded protein contains [[N-terminus|N-terminal]] sites for [[myristoylation]] and [[palmitoylation]], a PTK domain, and [[SH2 domain|SH2]] and [[SH3 domain|SH3]] domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell [[cell migration|migration]] and [[cell adhesion|adhesion]] triggered by the beta-2 [[integrin]] signal transduction pathway. Infection with [[Epstein-Barr virus]] results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2268| accessdate = }}</ref>
-}}
-==References==
+== Discovery  ==
-{{reflist|2}}
-==Further reading==
+The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.<ref name="pmid6175084">{{cite journal | vauthors = Rasheed S, Barbacid M, Aaronson S, Gardner MB | title = Origin and biological properties of a new feline sarcoma virus | journal = Virology | volume = 117 | issue = 1 | pages = 238–44 | date = Feb 1982 | pmid = 6175084 | doi = 10.1016/0042-6822(82)90522-0 }}</ref>
+== Interactions ==
+FGR (gene) has been shown to [[Protein-protein interaction|interact]] with [[Wiskott-Aldrich syndrome protein]].<ref name=pmid8805332>{{cite journal | vauthors = Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I | title = Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases | journal = Current Biology | volume = 6 | issue = 8 | pages = 981–8 | date = Aug 1996 | pmid = 8805332 | doi = 10.1016/S0960-9822(02)00642-5 }}</ref><ref name=pmid8824280>{{cite journal | vauthors = Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O, Hsuan JJ, Kellie S | title = Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains | journal = The Journal of Biological Chemistry | volume = 271 | issue = 42 | pages = 26291–5 | date = Oct 1996 | pmid = 8824280 | doi = 10.1074/jbc.271.42.26291 }}</ref><ref name=pmid7565724>{{cite journal | vauthors = Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC | title = Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains | journal = Molecular and Cellular Biology | volume = 15 | issue = 10 | pages = 5725–31 | date = Oct 1995 | pmid = 7565724 | pmc = 230823 }}</ref>
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Patel M, Faulkner L, Katz DR, Brickell PM | title = The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages | journal = Pathobiology | volume = 59 | issue = 4 | pages = 289–92 | year = 1991 | pmid = 1652975 | doi = 10.1159/000163665 }}
-| citations =
+* {{cite journal | vauthors = Resh MD | title = Myristylation and palmitylation of Src family members: the fats of the matter | journal = Cell | volume = 76 | issue = 3 | pages = 411–3 | date = Feb 1994 | pmid = 8313462 | doi = 10.1016/0092-8674(94)90104-X }}
-*{{cite journal  | author=Patel M, Faulkner L, Katz DR, Brickell PM |title=The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages. |journal=Pathobiology |volume=59 |issue= 4 |pages= 289-92 |year= 1991 |pmid= 1652975 |doi=  }}
+* {{cite journal | vauthors = Lowell CA, Berton G | title = Integrin signal transduction in myeloid leukocytes | journal = Journal of Leukocyte Biology | volume = 65 | issue = 3 | pages = 313–20 | date = Mar 1999 | pmid = 10080533 | doi =  }}
-*{{cite journal  | author=Resh MD |title=Myristylation and palmitylation of Src family members: the fats of the matter. |journal=Cell |volume=76 |issue= 3 |pages= 411-3 |year= 1994 |pmid= 8313462 |doi=  }}
+* {{cite journal | vauthors = Snapper SB, Rosen FS | title = The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization | journal = Annual Review of Immunology | volume = 17 | issue = 1 | pages = 905–29 | year = 1999 | pmid = 10358777 | doi = 10.1146/annurev.immunol.17.1.905 }}
-*{{cite journal  | author=Lowell CA, Berton G |title=Integrin signal transduction in myeloid leukocytes. |journal=J. Leukoc. Biol. |volume=65 |issue= 3 |pages= 313-20 |year= 1999 |pmid= 10080533 |doi=  }}
+* {{cite journal | vauthors = Tatosyan AG, Mizenina OA | title = Kinases of the Src family: structure and functions | journal = Biochemistry. Biokhimii͡A | volume = 65 | issue = 1 | pages = 49–58 | date = Jan 2000 | pmid = 10702640 | doi =  }}
-*{{cite journal  | author=Snapper SB, Rosen FS |title=The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization. |journal=Annu. Rev. Immunol. |volume=17 |issue=  |pages= 905-29 |year= 1999 |pmid= 10358777 |doi= 10.1146/annurev.immunol.17.1.905 }}
+* {{cite journal | vauthors = Patel MS, Mankoo BS, Brickell PM | title = A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1 | journal = Human Molecular Genetics | volume = 1 | issue = 1 | pages = 65 | date = Apr 1992 | pmid = 1339476 | doi = 10.1093/hmg/1.1.65-a }}
-*{{cite journal  | author=Tatosyan AG, Mizenina OA |title=Kinases of the Src family: structure and functions. |journal=Biochemistry Mosc. |volume=65 |issue= 1 |pages= 49-58 |year= 2000 |pmid= 10702640 |doi=  }}
+* {{cite journal | vauthors = Link DC, Gutkind SJ, Robbins KC, Ley TJ | title = Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter | journal = Oncogene | volume = 7 | issue = 5 | pages = 877–84 | date = May 1992 | pmid = 1373875 | doi =  }}
-*{{cite journal  | author=Patel MS, Mankoo BS, Brickell PM |title=A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1. |journal=Hum. Mol. Genet. |volume=1 |issue= 1 |pages= 65 |year= 1993 |pmid= 1339476 |doi=  }}
+* {{cite journal | vauthors = Patel M, Leevers SJ, Brickell PM | title = Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites | journal = Oncogene | volume = 5 | issue = 2 | pages = 201–6 | date = Feb 1990 | pmid = 1690869 | doi =  }}
-*{{cite journal  | author=Link DC, Gutkind SJ, Robbins KC, Ley TJ |title=Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter. |journal=Oncogene |volume=7 |issue= 5 |pages= 877-84 |year= 1992 |pmid= 1373875 |doi=  }}
+* {{cite journal | vauthors = Biondi A, Paganin C, Rossi V, Benvestito S, Perlmutter RM, Mantovani A, Allavena P | title = Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells | journal = European Journal of Immunology | volume = 21 | issue = 3 | pages = 843–6 | date = Mar 1991 | pmid = 1826268 | doi = 10.1002/eji.1830210348 }}
-*{{cite journal  | author=Patel M, Leevers SJ, Brickell PM |title=Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites. |journal=Oncogene |volume=5 |issue= 2 |pages= 201-6 |year= 1990 |pmid= 1690869 |doi=  }}
+* {{cite journal | vauthors = Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC | title = A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes | journal = Molecular and Cellular Biology | volume = 11 | issue = 3 | pages = 1500–7 | date = Mar 1991 | pmid = 1847500 | pmc = 369433 | doi =  }}
-*{{cite journal  | author=Biondi A, Paganin C, Rossi V, ''et al.'' |title=Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells. |journal=Eur. J. Immunol. |volume=21 |issue= 3 |pages= 843-6 |year= 1991 |pmid= 1826268 |doi=  }}
+* {{cite journal | vauthors = Patel M, Leevers SJ, Brickell PM | title = Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines | journal = International Journal of Cancer | volume = 45 | issue = 2 | pages = 342–6 | date = Feb 1990 | pmid = 2154410 | doi = 10.1002/ijc.2910450222 }}
-*{{cite journal  | author=Gutkind JS, Link DC, Katamine S, ''et al.'' |title=A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes. |journal=Mol. Cell. Biol. |volume=11 |issue= 3 |pages= 1500-7 |year= 1991 |pmid= 1847500 |doi=  }}
+* {{cite journal | vauthors = Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM | title = Isolation of duplicated human c-src genes located on chromosomes 1 and 20 | journal = Molecular and Cellular Biology | volume = 5 | issue = 4 | pages = 831–8 | date = Apr 1985 | pmid = 2581127 | pmc = 366788 | doi =  }}
-*{{cite journal  | author=Patel M, Leevers SJ, Brickell PM |title=Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines. |journal=Int. J. Cancer |volume=45 |issue= 2 |pages= 342-6 |year= 1990 |pmid= 2154410 |doi=  }}
+* {{cite journal | vauthors = Brickell PM, Patel M | title = Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines | journal = British Journal of Cancer | volume = 58 | issue = 6 | pages = 704–9 | date = Dec 1988 | pmid = 2852026 | pmc = 2246855 | doi = 10.1038/bjc.1988.294 }}
-*{{cite journal  | author=Parker RC, Mardon G, Lebo RV, ''et al.'' |title=Isolation of duplicated human c-src genes located on chromosomes 1 and 20. |journal=Mol. Cell. Biol. |volume=5 |issue= 4 |pages= 831-8 |year= 1985 |pmid= 2581127 |doi=  }}
+* {{cite journal | vauthors = Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC | title = Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 82 | issue = 19 | pages = 6595–9 | date = Oct 1985 | pmid = 2995972 | pmc = 391256 | doi = 10.1073/pnas.82.19.6595 }}
-*{{cite journal  | author=Brickell PM, Patel M |title=Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines. |journal=Br. J. Cancer |volume=58 |issue= 6 |pages= 704-9 |year= 1989 |pmid= 2852026 |doi=  }}
+* {{cite journal | vauthors = Cheah MS, Ley TJ, Tronick SR, Robbins KC | title = fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection | journal = Nature | volume = 319 | issue = 6050 | pages = 238–40 | year = 1986 | pmid = 3003578 | doi = 10.1038/319238a0 }}
-*{{cite journal  | author=Tronick SR, Popescu NC, Cheah MS, ''et al.'' |title=Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 19 |pages= 6595-9 |year= 1985 |pmid= 2995972 |doi=  }}
+* {{cite journal | vauthors = Nishizawa M, Semba K, Yoshida MC, Yamamoto T, Sasaki M, Toyoshima K | title = Structure, expression, and chromosomal location of the human c-fgr gene | journal = Molecular and Cellular Biology | volume = 6 | issue = 2 | pages = 511–7 | date = Feb 1986 | pmid = 3023853 | pmc = 367540 | doi =  }}
-*{{cite journal  | author=Cheah MS, Ley TJ, Tronick SR, Robbins KC |title=fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. |journal=Nature |volume=319 |issue= 6050 |pages= 238-40 |year= 1986 |pmid= 3003578 |doi= 10.1038/319238a0 }}
+* {{cite journal | vauthors = Katamine S, Notario V, Rao CD, Miki T, Cheah MS, Tronick SR, Robbins KC | title = Primary structure of the human fgr proto-oncogene product p55c-fgr | journal = Molecular and Cellular Biology | volume = 8 | issue = 1 | pages = 259–66 | date = Jan 1988 | pmid = 3275868 | pmc = 363113 | doi =  }}
-*{{cite journal  | author=Nishizawa M, Semba K, Yoshida MC, ''et al.'' |title=Structure, expression, and chromosomal location of the human c-fgr gene. |journal=Mol. Cell. Biol. |volume=6 |issue= 2 |pages= 511-7 |year= 1987 |pmid= 3023853 |doi=  }}
+* {{cite journal | vauthors = Inoue K, Ikawa S, Semba K, Sukegawa J, Yamamoto T, Toyoshima K | title = Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9 | journal = Oncogene | volume = 1 | issue = 3 | pages = 301–4 | year = 1988 | pmid = 3330776 | doi =  }}
-*{{cite journal  | author=Katamine S, Notario V, Rao CD, ''et al.'' |title=Primary structure of the human fgr proto-oncogene product p55c-fgr. |journal=Mol. Cell. Biol. |volume=8 |issue= 1 |pages= 259-66 |year= 1988 |pmid= 3275868 |doi=  }}
+* {{cite journal | vauthors = Nishizawa M, Semba K, Yamamoto T, Toyoshima K | title = Human c-f gr gene does not contain coding sequence for actin-like protein | journal = Japanese Journal of Cancer Research | volume = 76 | issue = 3 | pages = 155–9 | date = Mar 1985 | pmid = 3922831 | doi =  }}
-*{{cite journal  | author=Inoue K, Ikawa S, Semba K, ''et al.'' |title=Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9. |journal=Oncogene |volume=1 |issue= 3 |pages= 301-4 |year= 1988 |pmid= 3330776 |doi=  }}
-*{{cite journal  | author=Nishizawa M, Semba K, Yamamoto T, Toyoshima K |title=Human c-f gr gene does not contain coding sequence for actin-like protein. |journal=Jpn. J. Cancer Res. |volume=76 |issue= 3 |pages= 155-9 |year= 1985 |pmid= 3922831 |doi=  }}
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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

FGR (gene): Difference between revisions

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