FGFR1OP: Difference between revisions
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'''FGFR1 oncogene partner''' is a [[protein]] that in humans is encoded by the ''FGFR1OP'' [[gene]].<ref name="pmid9949182">{{cite journal | vauthors = Popovici C, Zhang B, | '''FGFR1 oncogene partner''' is a [[protein]] that in humans is encoded by the ''FGFR1OP'' [[gene]].<ref name="pmid9949182">{{cite journal | vauthors = Popovici C, Zhang B, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pébusque MJ | title = The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1 | journal = Blood | volume = 93 | issue = 4 | pages = 1381–9 | date = February 1999 | pmid = 9949182 | pmc = | doi = }}</ref><ref name="pmid10373756">{{cite journal | vauthors = Reither A, Hehlmann R, Goldman JM, Cross NC | title = [The 8p11 myeloproliferative syndrome] | journal = Medizinische Klinik | volume = 94 | issue = 4 | pages = 207–10 | date = April 1999 | pmid = 10373756 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FGFR1OP FGFR1 oncogene partner| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11116| access-date = }}</ref> | ||
== Function == | |||
==References== | This gene encodes a largely [[hydrophilic]] protein postulated to be a [[leucine]]-rich protein family member. A t(6;8)(q27;p11) [[chromosomal translocation]], fusing this gene and the fibroblast growth factor receptor 1 ([[FGFR1]]) gene, has been found in cases of [[myeloproliferative disorder]]. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal [[cell proliferation|proliferation]] and [[cell differentiation|differentiation]] of the [[erythroid]] lineage. Alternatively spliced [[transcript variants]] that encode different proteins have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: FGFR1OP FGFR1 oncogene partner| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11116| access-date = }}</ref> | ||
== References == | |||
{{reflist}} | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pébusque MJ | title = 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways | journal = Molecular and Cellular Biology | volume = 21 | issue = 23 | pages = 8129–42 | date = December 2001 | pmid = 11689702 | pmc = 99978 | doi = 10.1128/MCB.21.23.8129-8142.2001 }} | |||
* {{cite journal | vauthors = Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pébusque MJ | title = FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice | journal = Blood | volume = 103 | issue = 1 | pages = 309–12 | date = January 2004 | pmid = 12969958 | doi = 10.1182/blood-2003-05-1690 }} | |||
*{{cite journal | * {{cite journal | vauthors = Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M | title = Proteomic characterization of the human centrosome by protein correlation profiling | journal = Nature | volume = 426 | issue = 6966 | pages = 570–4 | date = December 2003 | pmid = 14654843 | doi = 10.1038/nature02166 }} | ||
*{{cite journal | * {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | date = May 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }} | ||
* {{cite journal | vauthors = Yan X, Habedanck R, Nigg EA | title = A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring | journal = Molecular Biology of the Cell | volume = 17 | issue = 2 | pages = 634–44 | date = February 2006 | pmid = 16314388 | pmc = 1356575 | doi = 10.1091/mbc.E05-08-0810 }} | |||
*{{cite journal | * {{cite journal | vauthors = Mikolajka A, Yan X, Popowicz GM, Smialowski P, Nigg EA, Holak TA | title = Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization | journal = Journal of Molecular Biology | volume = 359 | issue = 4 | pages = 863–75 | date = June 2006 | pmid = 16690081 | doi = 10.1016/j.jmb.2006.03.070 }} | ||
* {{cite journal | vauthors = Mano Y, Takahashi K, Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y | title = Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer | journal = Cancer Science | volume = 98 | issue = 12 | pages = 1902–13 | date = December 2007 | pmid = 17888034 | doi = 10.1111/j.1349-7006.2007.00610.x }} | |||
*{{cite journal | |||
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}} | |||
{{refend}} | {{refend}} | ||
==External links== | |||
*{{Commonscatinline}} | |||
{{PDB Gallery|geneid=11116}} | {{PDB Gallery|geneid=11116}} | ||
{{protein-stub}} | {{protein-stub}} |
Latest revision as of 13:17, 29 October 2018
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.[1][2][3]
Function
This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.[3]
References
- ↑ Popovici C, Zhang B, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pébusque MJ (February 1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood. 93 (4): 1381–9. PMID 9949182.
- ↑ Reither A, Hehlmann R, Goldman JM, Cross NC (April 1999). "[The 8p11 myeloproliferative syndrome]". Medizinische Klinik. 94 (4): 207–10. PMID 10373756.
- ↑ 3.0 3.1 "Entrez Gene: FGFR1OP FGFR1 oncogene partner".
Further reading
- Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pébusque MJ (December 2001). "8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways". Molecular and Cellular Biology. 21 (23): 8129–42. doi:10.1128/MCB.21.23.8129-8142.2001. PMC 99978. PMID 11689702.
- Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pébusque MJ (January 2004). "FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice". Blood. 103 (1): 309–12. doi:10.1182/blood-2003-05-1690. PMID 12969958.
- Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
- Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- Yan X, Habedanck R, Nigg EA (February 2006). "A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring". Molecular Biology of the Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
- Mikolajka A, Yan X, Popowicz GM, Smialowski P, Nigg EA, Holak TA (June 2006). "Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization". Journal of Molecular Biology. 359 (4): 863–75. doi:10.1016/j.jmb.2006.03.070. PMID 16690081.
- Mano Y, Takahashi K, Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y (December 2007). "Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer". Cancer Science. 98 (12): 1902–13. doi:10.1111/j.1349-7006.2007.00610.x. PMID 17888034.
External links
- Media related to [[commons:Lua error in Module:WikidataIB at line 428: attempt to index field 'wikibase' (a nil value).|Lua error in Module:WikidataIB at line 428: attempt to index field 'wikibase' (a nil value).]] at Wikimedia Commons
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