FGFR1OP: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Underlinked|date=May 2016}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''FGFR1 oncogene partner''' is a [[protein]] that in humans is encoded by the ''FGFR1OP'' [[gene]].<ref name="pmid9949182">{{cite journal | vauthors = Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ | title = The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1 | journal = Blood | volume = 93 | issue = 4 | pages = 1381–9 |date=Mar 1999 | pmid = 9949182 | pmc =  | doi =  }}</ref><ref name="pmid10373756">{{cite journal | vauthors = Reither A, Hehlmann R, Goldman JM, Cross NC | title = [The 8p11 myeloproliferative syndrome] | journal = Med Klin (Munich) | volume = 94 | issue = 4 | pages = 207–10 |date=Aug 1999 | pmid = 10373756 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FGFR1OP FGFR1 oncogene partner| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11116| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FGFR1OP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2d68.
| PDB = {{PDB2|2d68}}
| Name = FGFR1 oncogene partner
| HGNCid = 17012
| Symbol = FGFR1OP
| AltSymbols =; FOP
| OMIM = 605392
| ECnumber =
| Homologene = 5116
| MGIid = 1922546
| Function =  
  | Component =  
  | Process = {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11116
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_008976
    | Hs_RefseqmRNA = NM_007045
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =
    | Hs_GenLoc_end =
    | Hs_Uniprot =   
    | Mm_EntrezGene = 75296
    | Mm_Ensembl = ENSMUSG00000069135
    | Mm_RefseqmRNA = XM_975774
    | Mm_RefseqProtein = XP_980868
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 8003706
    | Mm_GenLoc_end = 8034977
    | Mm_Uniprot = Q8C0Y5
  }}
}}
'''FGFR1 oncogene partner''', also known as '''FGFR1OP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FGFR1OP FGFR1 oncogene partner| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11116| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: FGFR1OP FGFR1 oncogene partner| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11116| accessdate = }}</ref>
| summary_text = This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: FGFR1OP FGFR1 oncogene partner| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11116| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Reither A, Hehlmann R, Goldman JM, Cross NC |title=[The 8p11 myeloproliferative syndrome] |journal=Med. Klin. (Munich) |volume=94 |issue= 4 |pages= 207-10 |year= 1999 |pmid= 10373756 |doi=  }}
*{{cite journal  | vauthors=Guasch G, Ollendorff V, Borg JP |title=8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 8129–42 |year= 2001 |pmid= 11689702 |doi= 10.1128/MCB.21.23.8129-8142.2001 | pmc=99978 |display-authors=etal}}
*{{cite journal  | author=Popovici C, Zhang B, Grégoire MJ, ''et al.'' |title=The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. |journal=Blood |volume=93 |issue= 4 |pages= 1381-9 |year= 1999 |pmid= 9949182 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Guasch G, Ollendorff V, Borg JP, ''et al.'' |title=8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 8129-42 |year= 2001 |pmid= 11689702 |doi= 10.1128/MCB.21.23.8129-8142.2001 }}
*{{cite journal  | vauthors=Guasch G, Delaval B, Arnoulet C |title=FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice. |journal=Blood |volume=103 |issue= 1 |pages= 309–12 |year= 2004 |pmid= 12969958 |doi= 10.1182/blood-2003-05-1690 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
*{{cite journal  | author=Guasch G, Delaval B, Arnoulet C, ''et al.'' |title=FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice. |journal=Blood |volume=103 |issue= 1 |pages= 309-12 |year= 2004 |pmid= 12969958 |doi= 10.1182/blood-2003-05-1690 }}
*{{cite journal  | vauthors=Andersen JS, Wilkinson CJ, Mayor T |title=Proteomic characterization of the human centrosome by protein correlation profiling. |journal=Nature |volume=426 |issue= 6966 |pages= 570–4 |year= 2003 |pmid= 14654843 |doi= 10.1038/nature02166 |display-authors=etal}}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Wilkinson CJ, Mayor T, ''et al.'' |title=Proteomic characterization of the human centrosome by protein correlation profiling. |journal=Nature |volume=426 |issue= 6966 |pages= 570-4 |year= 2003 |pmid= 14654843 |doi= 10.1038/nature02166 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal  | vauthors=Yan X, Habedanck R, Nigg EA |title=A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. |journal=Mol. Biol. Cell |volume=17 |issue= 2 |pages= 634–44 |year= 2006 |pmid= 16314388 |doi= 10.1091/mbc.E05-08-0810 | pmc=1356575 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Mikolajka A, Yan X, Popowicz GM |title=Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. |journal=J. Mol. Biol. |volume=359 |issue= 4 |pages= 863–75 |year= 2006 |pmid= 16690081 |doi= 10.1016/j.jmb.2006.03.070 |display-authors=etal}}
*{{cite journal  | author=Yan X, Habedanck R, Nigg EA |title=A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. |journal=Mol. Biol. Cell |volume=17 |issue= 2 |pages= 634-44 |year= 2006 |pmid= 16314388 |doi= 10.1091/mbc.E05-08-0810 }}
*{{cite journal  | vauthors=Mano Y, Takahashi K, Ishikawa N |title=Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. |journal=Cancer Sci. |volume=98 |issue= 12 |pages= 1902–13 |year= 2007 |pmid= 17888034 |doi= 10.1111/j.1349-7006.2007.00610.x |display-authors=etal}}
*{{cite journal  | author=Mikolajka A, Yan X, Popowicz GM, ''et al.'' |title=Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. |journal=J. Mol. Biol. |volume=359 |issue= 4 |pages= 863-75 |year= 2006 |pmid= 16690081 |doi= 10.1016/j.jmb.2006.03.070 }}
*{{cite journal  | author=Mano Y, Takahashi K, Ishikawa N, ''et al.'' |title=Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. |journal=Cancer Sci. |volume=98 |issue= 12 |pages= 1902-13 |year= 2007 |pmid= 17888034 |doi= 10.1111/j.1349-7006.2007.00610.x }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=11116}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Revision as of 04:47, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.[1][2][3]

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.[3]

References

  1. ↑ Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ (Mar 1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood. 93 (4): 1381–9. PMID 9949182.
  2. ↑ Reither A, Hehlmann R, Goldman JM, Cross NC (Aug 1999). "[The 8p11 myeloproliferative syndrome]". Med Klin (Munich). 94 (4): 207–10. PMID 10373756.
  3. ↑ 3.0 3.1 "Entrez Gene: FGFR1OP FGFR1 oncogene partner".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=FGFR1OP&oldid=1421097"