FGF18
| Fibroblast growth factor 18 | |||||||||||
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| Symbols | FGF18 ; FGF-18; ZFGF5 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2867 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Fibroblast growth factor 18, also known as FGF18, is a human gene.[1]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.[1]
References
Further reading
- Haque T, Nakada S, Hamdy RC (2007). "A review of FGF18: Its expression, signaling pathways and possible functions during embryogenesis and post-natal development". Histol. Histopathol. 22 (1): 97–105. PMID 17128416.
- Ohbayashi N, Hoshikawa M, Kimura S; et al. (1998). "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18". J. Biol. Chem. 273 (29): 18161–4. PMID 9660775.
- Hu MC, Qiu WR, Wang YP; et al. (1998). "FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation". Mol. Cell. Biol. 18 (10): 6063–74. PMID 9742123.
- Hu MC, Wang YP, Qiu WR (1999). "Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to chromosome 14p11". Oncogene. 18 (16): 2635–42. doi:10.1038/sj.onc.1202616. PMID 10353607.
- Xu J, Liu Z, Ornitz DM (2000). "Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures". Development. 127 (9): 1833–43. PMID 10751172.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Whitmore TE, Maurer MF, Sexson S; et al. (2001). "Assignment of fibroblast growth factor 18 (FGF18) to human chromosome 5q34 by use of radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet. Cell Genet. 90 (3–4): 231–3. PMID 11124520.
- Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
- Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. doi:10.1074/jbc.M405795200. PMID 15199049.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
- Cormier S, Leroy C, Delezoide AL, Silve C (2005). "Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development". Gene Expr. Patterns. 5 (4): 569–73. doi:10.1016/j.modgep.2004.10.008. PMID 15749088.
- Antoine M, Wirz W, Tag CG; et al. (2005). "Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells". Growth Factors. 23 (2): 87–95. doi:10.1080/08977190500096004. PMID 16019430.
- Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
- Antoine M, Wirz W, Tag CG; et al. (2006). "Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation". Biochem. Biophys. Res. Commun. 346 (1): 224–33. doi:10.1016/j.bbrc.2006.05.105. PMID 16756958.
- Riley BM, Mansilla MA, Ma J; et al. (2007). "Impaired FGF signaling contributes to cleft lip and palate". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4512–7. doi:10.1073/pnas.0607956104. PMID 17360555.
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