FBXO5

F-box protein 5
Identifiers
Symbols	FBXO5 ; EMI1; FBX5; Fbxo31
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8135
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

F-box protein 5, also known as FBXO5, is a human gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.

Further reading

• Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.CS1 maint: Multiple names: authors list (link)
• Cenciarelli C, Chiaur DS, Guardavaccaro D; et al. (1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winston JT, Koepp DM, Zhu C; et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chiaur DS, Murthy S, Cenciarelli C; et al. (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet. Cell Genet. 88 (3–4): 255–8. PMID 10828603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reimann JD, Freed E, Hsu JY; et al. (2001). "Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex". Cell. 105 (5): 645–55. PMID 11389834.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reimann JD, Jackson PK (2002). "Emi1 is required for cytostatic factor arrest in vertebrate eggs". Nature. 416 (6883): 850–4. doi:10.1038/416850a. PMID 11976684.
• Hsu JY, Reimann JD, Sørensen CS; et al. (2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Z, Hu CY, Mo BQ; et al. (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng. 22 (4): 380–4. PMID 12703993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Margottin-Goguet F, Hsu JY, Loktev A; et al. (2003). "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase". Dev. Cell. 4 (6): 813–26. PMID 12791267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moshe Y, Boulaire J, Pagano M, Hershko A (2004). "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome". Proc. Natl. Acad. Sci. U.S.A. 101 (21): 7937–42. doi:10.1073/pnas.0402442101. PMID 15148369.CS1 maint: Multiple names: authors list (link)
• Hansen DV, Loktev AV, Ban KH, Jackson PK (2005). "Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1". Mol. Biol. Cell. 15 (12): 5623–34. doi:10.1091/mbc.E04-07-0598. PMID 15469984.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eldridge AG, Loktev AV, Hansen DV; et al. (2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1". Cell. 124 (2): 367–80. doi:10.1016/j.cell.2005.10.038. PMID 16439210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehman NL, Verschuren EW, Hsu JY; et al. (2006). "Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells". Cell Cycle. 5 (14): 1569–73. PMID 16861914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miller JJ, Summers MK, Hansen DV; et al. (2006). "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor". Genes Dev. 20 (17): 2410–20. doi:10.1101/gad.1454006. PMID 16921029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marangos P, Verschuren EW, Chen R; et al. (2007). "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)". J. Cell Biol. 176 (1): 65–75. doi:10.1083/jcb.200607070. PMID 17190794.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)