FBXO5: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''F-box only protein 5''' is a [[protein]] that in humans is encoded by the ''FBXO5'' [[gene]].<ref name="pmid10531035">{{cite journal | vauthors = Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M | title = Identification of a family of human F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1177–9 | date = Dec 1999 | pmid = 10531035 | pmc =  | doi = 10.1016/S0960-9822(00)80020-2 }}</ref><ref name="pmid10531037">{{cite journal | vauthors = Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW | title = A family of mammalian F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1180–2 | date = Dec 1999 | pmid = 10531037 | pmc =  | doi = 10.1016/S0960-9822(00)80021-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FBXO5 F-box protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26271| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = F-box protein 5
| HGNCid = 13584
| Symbol = FBXO5
| AltSymbols =; EMI1; FBX5; Fbxo31
| OMIM = 606013
| ECnumber = 
| Homologene = 8135
| MGIid = 1914391
| GeneAtlas_image1 = PBB_GE_FBXO5_218875_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005819 |text = spindle}}
| Process = {{GNF_GO|id=GO:0000089 |text = mitotic metaphase}} {{GNF_GO|id=GO:0001556 |text = oocyte maturation}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007346 |text = regulation of progression through mitotic cell cycle}} {{GNF_GO|id=GO:0051301 |text = cell division}} {{GNF_GO|id=GO:0051436 |text = negative regulation of ubiquitin ligase activity during mitotic cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26271
    | Hs_Ensembl = ENSG00000112029
    | Hs_RefseqProtein = NP_036309
    | Hs_RefseqmRNA = NM_012177
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 153333353
    | Hs_GenLoc_end = 153346407
    | Hs_Uniprot = Q9UKT4
    | Mm_EntrezGene = 67141
    | Mm_Ensembl = ENSMUSG00000019773
    | Mm_RefseqmRNA = NM_025995
    | Mm_RefseqProtein = NP_080271
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 4541152
    | Mm_GenLoc_end = 4547381
    | Mm_Uniprot = Q7TSG3
  }}
}}
'''F-box protein 5''', also known as '''FBXO5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FBXO5 F-box protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26271| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.<ref name="entrez">{{cite web | title = Entrez Gene: FBXO5 F-box protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26271| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
FBXO5 has been shown to [[Protein-protein interaction|interact]] with:
* [[CDC20]],<ref name = pmid11988738/>
* [[FZR1]],<ref name = pmid11988738>{{cite journal | vauthors = Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK | title = E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1) | journal = Nat. Cell Biol. | volume = 4 | issue = 5 | pages = 358–66 | date = May 2002 | pmid = 11988738 | doi = 10.1038/ncb785 }}</ref>  and
* [[SKP1A]].<ref name = autogenerated1>{{cite journal | vauthors = Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M | title = Identification of a family of human F-box proteins | journal = Curr. Biol. | volume = 9 | issue = 20 | pages = 1177–9 | date = Oct 1999 | pmid = 10531035 | doi = 10.1016/S0960-9822(00)80020-2 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Gubin AN, Njoroge JM, Bouffard GG, Miller JL | title = Gene expression in proliferating human erythroid cells | journal = Genomics | volume = 59 | issue = 2 | pages = 168–77 | year = 1999 | pmid = 10409428 | doi = 10.1006/geno.1999.5855 }}
| citations =
* {{cite journal | vauthors = Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M | title = Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors | journal = Cytogenet. Cell Genet. | volume = 88 | issue = 3–4 | pages = 255–8 | year = 2000 | pmid = 10828603 | doi = 10.1159/000015532 }}
*{{cite journal | author=Gubin AN, Njoroge JM, Bouffard GG, Miller JL |title=Gene expression in proliferating human erythroid cells. |journal=Genomics |volume=59 |issue= 2 |pages= 168-77 |year= 1999 |pmid= 10409428 |doi= 10.1006/geno.1999.5855 }}
* {{cite journal | vauthors = Reimann JD, Freed E, Hsu JY, Kramer ER, Peters JM, Jackson PK | title = Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex | journal = Cell | volume = 105 | issue = 5 | pages = 645–55 | year = 2001 | pmid = 11389834 | doi = 10.1016/S0092-8674(01)00361-0 }}
*{{cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, ''et al.'' |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177-9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2 }}
* {{cite journal | vauthors = Reimann JD, Jackson PK | title = Emi1 is required for cytostatic factor arrest in vertebrate eggs | journal = Nature | volume = 416 | issue = 6883 | pages = 850–4 | year = 2002 | pmid = 11976684 | doi = 10.1038/416850a }}
*{{cite journal  | author=Winston JT, Koepp DM, Zhu C, ''et al.'' |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180-2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4 }}
* {{cite journal | vauthors = Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK | title = E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1) | journal = Nat. Cell Biol. | volume = 4 | issue = 5 | pages = 358–66 | year = 2002 | pmid = 11988738 | doi = 10.1038/ncb785 }}
*{{cite journal  | author=Chiaur DS, Murthy S, Cenciarelli C, ''et al.'' |title=Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 255-8 |year= 2000 |pmid= 10828603 |doi= }}
* {{cite journal | vauthors = Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y | title = [Effect of beta-carotene on gene expression of breast cancer cells] | journal = Ai Zheng | volume = 22 | issue = 4 | pages = 380–4 | year = 2003 | pmid = 12703993 | doi =  }}
*{{cite journal | author=Reimann JD, Freed E, Hsu JY, ''et al.'' |title=Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. |journal=Cell |volume=105 |issue= 5 |pages= 645-55 |year= 2001 |pmid= 11389834 |doi= }}
* {{cite journal | vauthors = Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK | title = Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase | journal = Dev. Cell | volume = 4 | issue = 6 | pages = 813–26 | year = 2003 | pmid = 12791267 | doi = 10.1016/S1534-5807(03)00153-9 }}
*{{cite journal | author=Reimann JD, Jackson PK |title=Emi1 is required for cytostatic factor arrest in vertebrate eggs. |journal=Nature |volume=416 |issue= 6883 |pages= 850-4 |year= 2002 |pmid= 11976684 |doi= 10.1038/416850a }}
* {{cite journal | vauthors = Moshe Y, Boulaire J, Pagano M, Hershko A | title = Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 21 | pages = 7937–42 | year = 2004 | pmid = 15148369 | pmc = 419535 | doi = 10.1073/pnas.0402442101 }}
*{{cite journal | author=Hsu JY, Reimann JD, Sørensen CS, ''et al.'' |title=E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). |journal=Nat. Cell Biol. |volume=4 |issue= 5 |pages= 358-66 |year= 2002 |pmid= 11988738 |doi= 10.1038/ncb785 }}
* {{cite journal | vauthors = Hansen DV, Loktev AV, Ban KH, Jackson PK | title = Plk1 Regulates Activation of the Anaphase Promoting Complex by Phosphorylating and Triggering SCFβTrCP-dependent Destruction of the APC Inhibitor Emi1 | journal = Mol. Biol. Cell | volume = 15 | issue = 12 | pages = 5623–34 | year = 2005 | pmid = 15469984 | pmc = 532041 | doi = 10.1091/mbc.E04-07-0598 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Li Z, Hu CY, Mo BQ, ''et al.'' |title=[Effect of beta-carotene on gene expression of breast cancer cells] |journal=Ai Zheng |volume=22 |issue= 4 |pages= 380-4 |year= 2003 |pmid= 12703993 |doi=  }}
* {{cite journal | vauthors = Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK | title = The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1 | journal = Cell | volume = 124 | issue = 2 | pages = 367–80 | year = 2006 | pmid = 16439210 | doi = 10.1016/j.cell.2005.10.038 }}
*{{cite journal | author=Margottin-Goguet F, Hsu JY, Loktev A, ''et al.'' |title=Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. |journal=Dev. Cell |volume=4 |issue= 6 |pages= 813-26 |year= 2003 |pmid= 12791267 |doi=  }}
* {{cite journal | vauthors = Lehman NL, Verschuren EW, Hsu JY, Cherry AM, Jackson PK | title = Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells | journal = Cell Cycle | volume = 5 | issue = 14 | pages = 1569–73 | year = 2006 | pmid = 16861914 | doi = 10.4161/cc.5.14.2925 }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
* {{cite journal | vauthors = Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK | title = Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor | journal = Genes Dev. | volume = 20 | issue = 17 | pages = 2410–20 | year = 2006 | pmid = 16921029 | pmc = 1560415 | doi = 10.1101/gad.1454006 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Marangos P, Verschuren EW, Chen R, Jackson PK, Carroll J | title = Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APCCdh1 | journal = J. Cell Biol. | volume = 176 | issue = 1 | pages = 65–75 | year = 2007 | pmid = 17190794 | pmc = 2063628 | doi = 10.1083/jcb.200607070 }}
*{{cite journal | author=Moshe Y, Boulaire J, Pagano M, Hershko A |title=Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 21 |pages= 7937-42 |year= 2004 |pmid= 15148369 |doi= 10.1073/pnas.0402442101 }}
*{{cite journal | author=Hansen DV, Loktev AV, Ban KH, Jackson PK |title=Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5623-34 |year= 2005 |pmid= 15469984 |doi= 10.1091/mbc.E04-07-0598 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Eldridge AG, Loktev AV, Hansen DV, ''et al.'' |title=The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. |journal=Cell |volume=124 |issue= 2 |pages= 367-80 |year= 2006 |pmid= 16439210 |doi= 10.1016/j.cell.2005.10.038 }}
*{{cite journal | author=Lehman NL, Verschuren EW, Hsu JY, ''et al.'' |title=Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells. |journal=Cell Cycle |volume=5 |issue= 14 |pages= 1569-73 |year= 2006 |pmid= 16861914 |doi= }}
*{{cite journal | author=Miller JJ, Summers MK, Hansen DV, ''et al.'' |title=Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. |journal=Genes Dev. |volume=20 |issue= 17 |pages= 2410-20 |year= 2006 |pmid= 16921029 |doi= 10.1101/gad.1454006 }}
*{{cite journal | author=Marangos P, Verschuren EW, Chen R, ''et al.'' |title=Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). |journal=J. Cell Biol. |volume=176 |issue= 1 |pages= 65-75 |year= 2007 |pmid= 17190794 |doi= 10.1083/jcb.200607070 }}
}}
{{refend}}
{{refend}}


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Revision as of 02:00, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.[1][2][3]

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.[3]

Interactions

FBXO5 has been shown to interact with:

References

  1. ↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
  2. ↑ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
  3. ↑ 3.0 3.1 "Entrez Gene: FBXO5 F-box protein 5".
  4. ↑ 4.0 4.1 Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738.
  5. ↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

Further reading


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