FARSA (gene): Difference between revisions
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'''Phenylalanyl-tRNA synthetase alpha chain''' is an [[enzyme]] that in humans is encoded by the ''FARSA'' [[gene]].<ref name="pmid9177188">{{cite journal | vauthors = Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA | title = Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 12 | pages = 6164–9 |date=Jul 1997 | pmid = 9177188 | pmc = 21020 | doi =10.1073/pnas.94.12.6164 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2193| accessdate = }}</ref> | '''Phenylalanyl-tRNA synthetase alpha chain''' is an [[enzyme]] that in humans is encoded by the ''FARSA'' [[gene]].<ref name="pmid9177188">{{cite journal | vauthors = Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA | title = Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 12 | pages = 6164–9 |date=Jul 1997 | pmid = 9177188 | pmc = 21020 | doi =10.1073/pnas.94.12.6164 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2193| accessdate = }}</ref> | ||
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| summary_text = Aminoacyl-tRNA synthetases are a class of enzymes that charge | | summary_text = Aminoacyl-tRNA synthetases are a class of enzymes that charge [[tRNA]]s with their cognate [[amino acid]]s. This gene encodes a product which is similar to the catalytic subunit of [[prokaryote|prokaryotic]] and [[Saccharomyces cerevisiae]] [[phenylalanyl]]-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression<ref name="entrez" /> | ||
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Latest revision as of 07:24, 30 August 2018
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Phenylalanyl-tRNA synthetase alpha chain is an enzyme that in humans is encoded by the FARSA gene.[1][2]
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression[2]
References
- ↑ Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA (Jul 1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc Natl Acad Sci U S A. 94 (12): 6164–9. doi:10.1073/pnas.94.12.6164. PMC 21020. PMID 9177188.
- ↑ 2.0 2.1 "Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit".
Further reading
- Rodova M, Ankilova V, Safro MG (1999). "Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells". Biochem. Biophys. Res. Commun. 255 (3): 765–73. doi:10.1006/bbrc.1999.0141. PMID 10049785.
- Sang Lee J, Gyu Park S, Park H, et al. (2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
- Moor N, Linshiz G, Safro M (2002). "Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes". Protein Expr. Purif. 24 (2): 260–7. doi:10.1006/prep.2001.1560. PMID 11858721.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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