FABP5

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene.

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.

Interactions

FABP5 has been shown to interact with S100A7.

Further reading

• Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
• Siegenthaler G, Hotz R, Chatellard-Gruaz D, et al. (1994). "Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro". Biochem. J. 302 (2): 363–71. PMC 1137237. PMID 8092987.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Siegenthaler G, Hotz R, Chatellard-Gruaz D, et al. (1993). "Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP)". Biochem. Biophys. Res. Commun. 190 (2): 482–7. doi:10.1006/bbrc.1993.1073. PMID 8427590.
• Masouyé I, Saurat JH, Siegenthaler G (1996). "Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study". Dermatology. 192 (3): 208–13. doi:10.1159/000246367. PMID 8726632.
• Jaworski C, Wistow G (1997). "LP2, a differentiation-associated lipid-binding protein expressed in bovine lens". Biochem. J. 320 (1): 49–54. PMC 1217896. PMID 8947466.
• Masouyé I, Hagens G, Van Kuppevelt TH, et al. (1997). "Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein". Circ. Res. 81 (3): 297–303. doi:10.1161/01.res.81.3.297. PMID 9285630.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Watanabe R, Fujii H, Yamamoto A, et al. (1998). "Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin". J. Dermatol. Sci. 16 (1): 17–22. doi:10.1016/S0923-1811(97)00615-4. PMID 9438903.
• Hagens G, Masouyé I, Augsburger E, et al. (1999). "Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes". Biochem. J. 339 (2): 419–27. doi:10.1042/0264-6021:3390419. PMC 1220173. PMID 10191275.
• Hagens G, Roulin K, Hotz R, et al. (1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. 192 (1–2): 123–8. doi:10.1023/A:1006894909694. PMID 10331666.
• Hohoff C, Börchers T, Rüstow B, et al. (1999). "Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein". Biochemistry. 38 (38): 12229–39. doi:10.1021/bi990305u. PMID 10493790.
• O'Shaughnessy RF, Seery JP, Celis JE, et al. (2001). "PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation". FEBS Lett. 486 (2): 149–54. doi:10.1016/S0014-5793(00)02252-3. PMID 11113456.
• Gutiérrez-González LH, Ludwig C, Hohoff C, et al. (2002). "Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP)". Biochem. J. 364 (Pt 3): 725–37. doi:10.1042/BJ20020039. PMC 1222622. PMID 12049637.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Ruse M, Broome AM, Eckert RL (2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. 121 (1): 132–41. doi:10.1046/j.1523-1747.2003.12309.x. PMID 12839573.
• Ha MK, Chung KY, Lee JH, et al. (2005). "Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells". Exp. Dermatol. 13 (9): 543–50. doi:10.1111/j.0906-6705.2004.00196.x. PMID 15335354.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.