F11 receptor

F11 receptor
PDB rendering based on 1nbq.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1nbq​
Identifiers
Symbols	F11R ; KAT; CD321; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; PAM-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 14255
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

F11 receptor, also known as F11R, is a human gene. KDR has also been designated as CD321 (cluster of differentiation 321).

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple transcript variants encoding two different isoforms have been found for this gene.

Further reading

• Muller WA (2003). "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response". Trends Immunol. 24 (6): 327–34. PMID 12810109.
• Bazzoni G (2004). "The JAM family of junctional adhesion molecules". Curr. Opin. Cell Biol. 15 (5): 525–30. PMID 14519386.
• Naik UP, Eckfeld K (2004). "Junctional adhesion molecule 1 (JAM-1)". J. Biol. Regul. Homeost. Agents. 17 (4): 341–7. PMID 15065765.
• Kornecki E, Walkowiak B, Naik UP, Ehrlich YH (1990). "Activation of human platelets by a stimulatory monoclonal antibody". J. Biol. Chem. 265 (17): 10042–8. PMID 2351647.CS1 maint: Multiple names: authors list (link)
• Naik UP, Ehrlich YH, Kornecki E (1995). "Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor". Biochem. J. 310 ( Pt 1): 155–62. PMID 7646439.CS1 maint: Multiple names: authors list (link)
• Ozaki H, Ishii K, Horiuchi H; et al. (1999). "Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells". J. Immunol. 163 (2): 553–7. PMID 10395639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Williams LA, Martin-Padura I, Dejana E; et al. (2000). "Identification and characterisation of human Junctional Adhesion Molecule (JAM)". Mol. Immunol. 36 (17): 1175–88. PMID 10698320.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sobocka MB, Sobocki T, Banerjee P; et al. (2000). "Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation". Blood. 95 (8): 2600–9. PMID 10753840.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Y, Nusrat A, Schnell FJ; et al. (2000). "Human junction adhesion molecule regulates tight junction resealing in epithelia". J. Cell. Sci. 113 ( Pt 13): 2363–74. PMID 10852816.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ebnet K, Schulz CU, Meyer Zu Brickwedde MK; et al. (2000). "Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1". J. Biol. Chem. 275 (36): 27979–88. doi:10.1074/jbc.M002363200. PMID 10856295.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bazzoni G, Martinez-Estrada OM, Orsenigo F; et al. (2000). "Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin". J. Biol. Chem. 275 (27): 20520–6. doi:10.1074/jbc.M905251199. PMID 10877843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta SK, Pillarisetti K, Ohlstein EH (2001). "Platelet agonist F11 receptor is a member of the immunoglobulin superfamily and identical with junctional adhesion molecule (JAM): regulation of expression in human endothelial cells and macrophages". IUBMB Life. 50 (1): 51–6. PMID 11087121.CS1 maint: Multiple names: authors list (link)
• Martinez-Estrada OM, Villa A, Breviario F; et al. (2001). "Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells". J. Biol. Chem. 276 (12): 9291–6. doi:10.1074/jbc.M006991200. PMID 11120739.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Naik UP, Naik MU, Eckfeld K; et al. (2001). "Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody". J. Cell. Sci. 114 (Pt 3): 539–47. PMID 11171323.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barton ES, Forrest JC, Connolly JL; et al. (2001). "Junction adhesion molecule is a receptor for reovirus". Cell. 104 (3): 441–51. PMID 11239401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ebnet K, Suzuki A, Horikoshi Y; et al. (2001). "The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)". EMBO J. 20 (14): 3738–48. doi:10.1093/emboj/20.14.3738. PMID 11447115.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Itoh M, Sasaki H, Furuse M; et al. (2001). "Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions". J. Cell Biol. 154 (3): 491–7. doi:10.1083/jcb.200103047. PMID 11489913.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamazaki Y, Itoh M, Sasaki H; et al. (2002). "Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". J. Biol. Chem. 277 (1): 455–61. doi:10.1074/jbc.M109005200. PMID 11689568.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• KDR+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.