Eye neoplasm

Eye Neoplasm Microchapters
Patient Information
Overview
Classification Choroidal Tumors Conjunctival Tumors
Causes
Differential Diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Eye neoplasm; eye cancer

Overview

Ocular oncology is the branch of medicine dealing with tumors relating to the eye and its adnexa. Eye cancer can affect all parts of the eye.

Classification

Choroidal tumors

• Choroidal hemangioma

• Choroidal melanoma

• Choroidal metastasis

• Choroidal nevus

• Choroidal osteoma

• Ciliary body melanoma

• The nevus of Ota

Conjunctival tumors

File:Conjunctival carcinoma - 6.jpg

Advanced conjunctival carcinoma protruding through the palpebral fissure.

• Conjunctival Kaposi's sarcoma

• Epibulbar dermoid

• Malignant conjunctival tumors

• Lymphoma of the conjunctiva

• Melanoma and PAM with atypia

• Pigmented conjunctival tumors

• Pingueculum

• Pterygium

• Squamous carcinoma and intraepithelial neoplasia of the conjunctiva

Epidemiology and Demographics

Origin and location

Eye cancers can be primary (starts within the eye) and metastatic cancer (spread to the eye from another organ). The two most common cancers that spread to the eye from another organ are breast cancer and lung cancer. Other less common sites of origin include the prostate, kidney, thyroid, skin, colon and blood or bone marrow.

Types

Tumors in the eye and orbit can be benign like dermoid cysts, or malignant like rhabdomyosarcoma and retinoblastoma.

Malignant

The most common eyelid tumor is called basal cell carcinoma. This tumor can grow around the eye but rarely spreads to other parts of the body. Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. The most common orbital malignancy is orbital lymphoma. This tumor can be diagnosed by biopsy with histopathologic and immunohistochemical analysis. Most patients with orbital lymphoma can be offered chemotherapy or radiation therapy.

Adults

• The most common malignant primary intraocular tumor in adults is uveal melanoma. These tumors can occur in the choroid, iris and ciliary body. The latter are sometimes called iris or ciliary body melanoma.
• The next most common is primary intraocular lymphoma (PIOL) which is usually non-Hodgkin’s, large cell lymphoma of the B-cell type, although T cell lymphomas have also been described.

Children

• The most common malignant intraocular tumor in children is retinoblastoma, affecting approximately 325 children per year in North America. Early detection has allowed for cures exceeding 95%.
• The second most common is medulloepithelioma (also called diktyoma) which can occur in the ciliary body and the uvea of the eye.

Benign

Orbital dermoid cysts are benign choristomas which are typically found at the junction of sutures, most commonly at the fronto-zygomatic suture. Large deep orbital dermoid cysts can cause pressure effects on the muscles and optic nerve, leading to diplopia and loss of vision.

Diagnosis

History and Symptoms | Physical Examination | CT | MRI | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Related Chapters

• List of eye diseases and disorders