Extranodal NK-T-cell lymphoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
First known case of Natural-Killer-cell lymphoma was diagnosed in a 19-years old boy. The diagnosis of Natural-Killer-cell lymphoma was confirmed by pathology as Wegener's Granulomatosis was ruled out.
Historical Perspective
- First known case of Natural-Killer-cell lymphoma was a 19-years old man, with a tumor affecting nasal cavity.[1]
- Natural-Killer-cell lymphoma was diagnosed as "Granuloma Gangraenescens" which was considered as unclassified sarcoma.
- The diagnosis of Natural-Killer-cell lymphoma was confirmed by pathology as Wegener's Granulomatosis was ruled out.
- 33 years later,in 1998, the patient had a relapse with skin lesions which progressed with nasal involvement in 2002, and the final mortal relapse was in 2003 with leukemic disease.
- Reanalysis of stored slides of 1965 revealed an immunophenotype typical of NK cell which was similar to those found in 1998 skin lesions, 2002 nasal tissue and 2003 blood.
- Biopsy specimen collected in 1998 and 2002 contained EBV virus encoded RNA transcripts and then diagnosed as a Natural-killer-cell lymphoma.
References
- ↑ Schrader C, Janssen D, Kneba M, Lennert K (2004). "A 38-year history of natural-killer-cell lymphoma". N Engl J Med. 350 (4): 418–9. doi:10.1056/NEJM200401223500423. PMID 14736941.