Extranodal NK-T-cell lymphoma differential diagnosis: Difference between revisions
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Extranodal NK/T-cell lymphoma, nasal type must be diffrentiated from [[Wegener's granulomatosis|Wegner's granulomatosis]], [[Polymorphic]] reticulosis, and Midline malignant [[Lymphomas|lymphoma]].<ref name="pmid58185232">{{cite journal| author=Kassel SH, Echevarria RA, Guzzo FP| title=Midline malignant reticulosis (so-called lethal midline granuloma). | journal=Cancer | year= 1969 | volume= 23 | issue= 4 | pages= 920-35 | pmid=5818523 | doi=10.1002/1097-0142(196904)23:4<920::aid-cncr2820230430>3.0.co;2-m | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5818523 }}</ref> | Extranodal NK/T-cell lymphoma, nasal type must be diffrentiated from [[Wegener's granulomatosis|Wegner's granulomatosis]], [[Polymorphic]] reticulosis, and Midline malignant [[Lymphomas|lymphoma]].<ref name="pmid58185232">{{cite journal| author=Kassel SH, Echevarria RA, Guzzo FP| title=Midline malignant reticulosis (so-called lethal midline granuloma). | journal=Cancer | year= 1969 | volume= 23 | issue= 4 | pages= 920-35 | pmid=5818523 | doi=10.1002/1097-0142(196904)23:4<920::aid-cncr2820230430>3.0.co;2-m | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5818523 }}</ref> | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Extranodal NK t-cell must be differentiated with other NK and T cell hematologic malignancies and EBV-associated T cell or NK cell lymphoprolifrative disorders.<ref name="KarubeAoki2008">{{cite journal|last1=Karube|first1=Kennosuke|last2=Aoki|first2=Ryosuke|last3=Nomura|first3=Yuko|last4=Yamamoto|first4=Kohei|last5=Shimizu|first5=Kay|last6=Yoshida|first6=Shirou|last7=Komatani|first7=Hideki|last8=Sugita|first8=Yasuo|last9=Ohshima|first9=Koichi|title=Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: Analysis of 490 cases|journal=Pathology International|volume=58|issue=2|year=2008|pages=89–97|issn=13205463|doi=10.1111/j.1440-1827.2007.02195.x}}</ref> | |||
Extranodal NK-T-cell lymphoma must be differentiated from other diseases such as:<ref name="Hindawi">Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 19, 2016</ref> | Extranodal NK-T-cell lymphoma must be differentiated from other diseases such as:<ref name="Hindawi">Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 19, 2016</ref> | ||
* [[Anaplastic large cell lymphoma]] | |||
*[[NK cell lukemia]] | |||
*[[Anaplastic large cell lymphoma]] | |||
* Non specific inflammatory process | * Non specific inflammatory process | ||
* [[Enteropathy associated T cell lymphoma]] | *[[Enteropathy associated T cell lymphoma]] | ||
* [[Peripheral T cell lymphoma]] | *[[Peripheral T cell lymphoma]] | ||
Extranodal NK-T cell lymphoma, nasal type shows aggresive lethal midline granuloma macroscopicaly so it must be differentiated from diseases such as:<ref name="pmid5818523">{{cite journal| author=Kassel SH, Echevarria RA, Guzzo FP| title=Midline malignant reticulosis (so-called lethal midline granuloma). | journal=Cancer | year= 1969 | volume= 23 | issue= 4 | pages= 920-35 | pmid=5818523 | doi=10.1002/1097-0142(196904)23:4<920::aid-cncr2820230430>3.0.co;2-m | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5818523 }}</ref> | Extranodal NK-T cell lymphoma, nasal type shows aggresive lethal midline granuloma macroscopicaly so it must be differentiated from diseases such as:<ref name="pmid5818523">{{cite journal| author=Kassel SH, Echevarria RA, Guzzo FP| title=Midline malignant reticulosis (so-called lethal midline granuloma). | journal=Cancer | year= 1969 | volume= 23 | issue= 4 | pages= 920-35 | pmid=5818523 | doi=10.1002/1097-0142(196904)23:4<920::aid-cncr2820230430>3.0.co;2-m | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=5818523 }}</ref> | ||
| Line 19: | Line 23: | ||
* Midline malignant [[Lymphomas|lymphoma]] | * Midline malignant [[Lymphomas|lymphoma]] | ||
=== Differentiating extranodal NK T-cell from other hematologic malignancies by immunophenotype and EBV infection: === | |||
{| class="wikitable sortable mw-collapsible mw-collapsed" | |||
|+ | |||
!Disease | |||
!immunophenotype | |||
| | !EBV | ||
! | |||
|- | |- | ||
| | |[[NK cell leukemia]] | ||
|CD16+ | |||
| + | |||
|- | |- | ||
|[[Lymphomatoid granulomatosis]] | |||
|CD20+ | |||
| + | |||
|- | |- | ||
| | |[[Diffuse large B cell lymphoma|EBV-positive diffuse large B cell lymphoma, NOS]] | ||
|CD20+ & CD76+ | |||
| + | |||
| | |||
| | |||
|- | |- | ||
| | |[[Peripheral T cell lymphoma|Peripheral T cell lymphoma, unspecified]] | ||
| | |CD3+ & CD56- | ||
| | | - | ||
|- | |- | ||
| | |[[Anaplastic large cell lymphoma, ALK positive|Anaplastic large cell lymphoma]] | ||
|CD30+ | |||
| - | |||
| | |||
|- | |||
|- | |- | ||
| | |[[Hepatosplenic T cell lymphoma]] | ||
|CD2+ & CD7+&CD3+ | |||
| - | |||
| | |||
|- | |||
|} | |} | ||
==References== | ==References== | ||
Revision as of 14:37, 26 August 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
Extranodal NK-T-cell lymphoma must be differentiated from other diseases such as anaplastic large cell lymphoma, non specific inflammatory process, enteropathy associated T cell lymphoma, and peripheral T cell lymphoma.[1]
Extranodal NK/T-cell lymphoma, nasal type must be diffrentiated from Wegner's granulomatosis, Polymorphic reticulosis, and Midline malignant lymphoma.[2]
Differential Diagnosis
Extranodal NK t-cell must be differentiated with other NK and T cell hematologic malignancies and EBV-associated T cell or NK cell lymphoprolifrative disorders.[3]
Extranodal NK-T-cell lymphoma must be differentiated from other diseases such as:[1]
- NK cell lukemia
- Anaplastic large cell lymphoma
- Non specific inflammatory process
- Enteropathy associated T cell lymphoma
- Peripheral T cell lymphoma
Extranodal NK-T cell lymphoma, nasal type shows aggresive lethal midline granuloma macroscopicaly so it must be differentiated from diseases such as:[4]
- Wegner's granulomatosis
- Polymorphic reticulosis
- Midline malignant lymphoma
Differentiating extranodal NK T-cell from other hematologic malignancies by immunophenotype and EBV infection:
| Disease | immunophenotype | EBV |
|---|---|---|
| NK cell leukemia | CD16+ | + |
| Lymphomatoid granulomatosis | CD20+ | + |
| EBV-positive diffuse large B cell lymphoma, NOS | CD20+ & CD76+ | + |
| Peripheral T cell lymphoma, unspecified | CD3+ & CD56- | - |
| Anaplastic large cell lymphoma | CD30+ | - |
| Hepatosplenic T cell lymphoma | CD2+ & CD7+&CD3+ | - |
References
- ↑ 1.0 1.1 Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 19, 2016
- ↑ Kassel SH, Echevarria RA, Guzzo FP (1969). "Midline malignant reticulosis (so-called lethal midline granuloma)". Cancer. 23 (4): 920–35. doi:10.1002/1097-0142(196904)23:4<920::aid-cncr2820230430>3.0.co;2-m. PMID 5818523.
- ↑ Karube, Kennosuke; Aoki, Ryosuke; Nomura, Yuko; Yamamoto, Kohei; Shimizu, Kay; Yoshida, Shirou; Komatani, Hideki; Sugita, Yasuo; Ohshima, Koichi (2008). "Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: Analysis of 490 cases". Pathology International. 58 (2): 89–97. doi:10.1111/j.1440-1827.2007.02195.x. ISSN 1320-5463.
- ↑ Kassel SH, Echevarria RA, Guzzo FP (1969). "Midline malignant reticulosis (so-called lethal midline granuloma)". Cancer. 23 (4): 920–35. doi:10.1002/1097-0142(196904)23:4<920::aid-cncr2820230430>3.0.co;2-m. PMID 5818523.