Etodolac: Difference between revisions

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{{drugbox
{{DrugProjectFormSinglePage
| IUPAC_name = 1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid
|authorTag=
| image = Etodolac.svg
 
| width = 250px
 
| CAS_number = 41340-25-4
<!--Overview-->
| ATC_prefix = M01
 
| ATC_suffix = AB08
|genericName=
| ATC_supplemental =  
 
| PubChem = 3308
 
| DrugBank = APRD00067
 
| C=17 | H=21 | N=1 | O=3
|aOrAn=
| molecular_weight = 287.354 g/mol
 
| bioavailability =  
a
| protein_bound = 100%
 
| metabolism =  
|drugClass=
| elimination_half-life = 7.3 ± 4.0 hours
 
| pregnancy_category =  
 
| legal_status =  
 
| routes_of_administration =  
|indication=
}}
 
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* Content
 
<!--Adult Indications and Dosage-->
 
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* Dosing Information
 
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=====Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
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<!--Non–Guideline-Supported Use (Adult)-->
 
|offLabelAdultNoGuideSupport=
 
=====Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
 
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=====Condition1=====
 
* Dosing Information
 
:* Dosage
 
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=====Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
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<!--Non–Guideline-Supported Use (Pediatric)-->
 
|offLabelPedNoGuideSupport=
 
=====Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
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|contraindications=
 
* Condition1
 
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|warnings=
 
* Description
 
====Precautions====
 
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<!--Adverse Reactions-->
 
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|clinicalTrials=
 
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=====Body as a Whole=====
 
 
 
 
=====Cardiovascular=====
 
 
 
 
=====Digestive=====
 
 
 
 
=====Endocrine=====
 
 
 
 
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=====Respiratory=====
 
 
 
 
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|postmarketing=
 
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=====Body as a Whole=====
 
 
 
=====Cardiovascular=====
 
 
 
=====Digestive=====
 
 
 
=====Endocrine=====
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
=====Metabolic and Nutritional=====
 
 
 
=====Musculoskeletal=====
 
 
 
=====Neurologic=====
 
 
 
=====Respiratory=====
 
 
 
=====Skin and Hypersensitivy Reactions=====
 
 
 
=====Special Senses=====
 
 
 
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* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
 
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* Oral
 
* Intravenous
 
|monitoring=
 
There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
 
* Description
 
<!--IV Compatibility-->
 
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There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.
 
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|overdose=
 
===Acute Overdose===
 
====Signs and Symptoms====
 
* Description
 
====Management====
 
* Description
 
===Chronic Overdose===
 
There is limited information regarding <i>Chronic Overdose</i> of {{PAGENAME}} in the drug label.
 
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*
 
: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
 
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<!--Pharmacokinetics-->
 
|PK=
 
There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.
 
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There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.


{{SI}}
<!--How Supplied-->


==Overview==
|howSupplied=
'''Etodolac''', [[International Nonproprietary Name]] (INN) of 1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid ([[empirical formula]] C<sub>17</sub>H<sub>21</sub>NO<sub>3</sub>), also sold under the [[trade name]] '''Lodine''' is a [[non-steroidal anti-inflammatory drug]] (NSAID) effective in treating [[fever]], [[pain]], and [[inflammation]] in the body.  As a group, NSAIDs are non-[[narcotic]] relievers of mild to moderate pain of many causes, including injury, menstrual cramps, [[arthritis]], and other [[Musculoskeletal system|musculoskeletal]] conditions.  Since the response to different NSAIDs varies from [[patient]] to patient, it is not unusual for a [[Physician|Doctor]] or [[General practitioner]] (GP) to try different NSAIDs for any given condition.


Etodolac is manufacturered by [[Shire plc|Shire]] under the tradename '''Lodine SR'''.  Etodolac is also available as a generic.
*


==Preparations==
<!--Patient Counseling Information-->
capsules: 200mg, 300mg; tablets: 400mg, 500mg and XL formulations as 400mg and 600mg.


==Prescribed for==
|fdaPatientInfo=
Etodolac is used for the [[Therapy|treatment]] of [[inflammation]] and pain caused by [[osteoarthritis]] and [[rheumatoid arthritis]], as well as soft tissue injuries, such as [[tendinitis]] and [[bursitis]].  Etodolac is also used for rapid relief of moderate to severe pain, such as with [[Dysmenorrhea|menstrual cramp]]s.


==Dosing==
There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.
Should be taken with food.


==Interactions==
<!--Precautions with Alcohol-->
Etodolac should be avoided by patients with a history of [[asthma]] attacks, [[Urticaria|hives]], or other [[Allergy|allergic reactions]] to [[aspirin]] or other NSAIDs.  Rare but severe allergic reactions have been reported in such individuals.  It also should be avoided by patients with [[peptic ulcer]] disease or poor [[Renal physiology|kidney function]], since this medication can aggravate both conditions.  Etodolac is generally used with caution in patients taking blood thinning medications ([[anticoagulant]]s), such as [[warfarin]] (Coumadin), because of increased risk of [[bleeding]].  Patients taking [[lithium]] can develop toxic blood lithium levels.  Patients also taking [[ciclosporin]] (Sandimmune) can develop kidney toxicity.  Use in [[children]] has not been adequately studied.  Etodolac is not habit-forming.  NSAIDs should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines.  Etodolac is best discontinued at least four days in advance of the procedure.


Persons who have more than 3 alcoholic beverages per day are at increased risk of developing stomach ulcers when taking etodolac or other NSAIDs.
|alcohol=


==Pregnancy==
* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Etodolac is generally avoided during [[pregnancy]].


==Nursing mothers==
<!--Brand Names-->
Etodolac is generally avoided in nursing mothers.


==Side Effects==
|brandNames=
Etodolac may cause [[side effects]], or [[Adverse drug reaction]].  Tell your doctor if any of these [[symptom]]s are severe or do not go away:


[[constipation]], [[diarrhea]], [[flatulence|gas]] or [[bloating]], [[vomiting]], [[headache]], [[dizziness]], [[Tinnitus|ringing in the ears]], [[Rhinorrhea|runny nose]], [[Pharyngitis|sore throat]], [[blurred vision]].
* ®<ref>{{Cite web | title =  | url =  }}</ref>


Some side effects can be ''serious''.  If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately.  Do not take any more etodolac until you speak to your doctor:
<!--Look-Alike Drug Names-->


unexplained [[weight gain]], [[Swelling (medical)|swelling]] of the [[eye]]s, [[face]], [[lip]]s, [[tongue]], [[throat]], [[hand]]s, [[Foot|feet]], [[ankle]]s, or [[Human leg|lower leg]]s, [[fever]] or [[Rigor (medicine)|chills]], [[blister]]s, [[rash]], [[itch]]ing, [[hives]], [[Dysphonia|hoarseness]], difficulty [[breath]]ing or [[swallowing]], yellowing of the skin or eyes, excessive [[Fatigue (medical)|tiredness]], unusual [[bleeding]] or [[Bruise|bruising]], lack of energy, [[Anorexia (symptom)|loss of appetite]], pain in the upper right part of the [[stomach]], [[Influenza|flu]]-like symptoms, pale skin, fast [[Cardiac cycle|heartbeat]], cloudy, discolored, or [[Hematuria|bloody urine]], difficult or painful [[urination]], [[back pain]].
|lookAlike=


Etodolac may cause other side effects.
* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>


Sold under the name Etogesic for veterinary use
<!--Drug Shortage Status-->


==References==
|drugShortage=
* [http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00749 DrugBank info]
}}
* [http://www.medicinenet.com/etodolac/article.htm]


==External links==
<!--Pill Image-->
*[http://www.rxlist.com/cgi/generic/etodolac.htm Information on Etodolac from rxlist.com]


{{NSAIDs}}
{{PillImage
{{Anti-inflammatory and antirheumatic products}}
|fileName=No image.jpg|This image is provided by the National Library of Medicine.
{{Analgesics}}
|drugName=
|NDC=
|drugAuthor=
|ingredients=
|pillImprint=
|dosageValue=
|dosageUnit=
|pillColor=
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|pillSize=
|pillScore=
}}


<!--Label Display Image-->


[[Category:Non-steroidal anti-inflammatory drugs]]
{{LabelImage
[[Category:Drugs]]
|fileName={{PAGENAME}}11.png|This image is provided by the National Library of Medicine.
}}
 
{{LabelImage
|fileName={{PAGENAME}}11.png|This image is provided by the National Library of Medicine.
}}


[[tr:Etodolak]]
<!--Category-->
[[vi:Etodolac]]


{{WH}}
[[Category:Drug]]
{{WS}}

Revision as of 18:15, 3 October 2014

Etodolac
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Etodolac is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Etodolac in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Etodolac in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Etodolac in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Etodolac in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Etodolac in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Etodolac in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Etodolac in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Etodolac in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Etodolac during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Etodolac with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Etodolac with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Etodolac with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Etodolac with respect to specific gender populations.

Race

There is no FDA guidance on the use of Etodolac with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Etodolac in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Etodolac in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Etodolac in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Etodolac in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Etodolac in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Etodolac in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Etodolac in the drug label.

Pharmacology

There is limited information regarding Etodolac Pharmacology in the drug label.

Mechanism of Action

Structure

File:Etodolac01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Etodolac in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Etodolac in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Etodolac in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Etodolac in the drug label.

How Supplied

Storage

There is limited information regarding Etodolac Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Etodolac |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Etodolac |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Etodolac in the drug label.

Precautions with Alcohol

  • Alcohol-Etodolac interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)


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