Etazolate

Etazolate
Clinical data
Synonyms	Etazolate
Identifiers
	IUPAC name Ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[4,5-e]pyridine-5-carboxylate;
CAS Number	51022-77-6;
PubChem CID	3277;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C14H19N5O2
Molar mass	289.33 g/mol
3D model (JSmol)	Interactive image;
	SMILES CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC;

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Etazolate is a pyrazolopyridine derivative drug,^[1] which acts as an anxiolytic.^[2]

It has several mechanisms of action, acting as an adenosine antagonist,^[3] a subtype-selective GABA_A receptor partial agonist,^[4] and a phosphodiesterase inhibitor selective for the PDE4 subtype.^[5]

References

↑ Ticku MK, Davis WC (1982). "Molecular interactions of etazolate with benzodiazepine and picrotoxinin binding sites". J. Neurochem. 38 (4): 1180–2. PMID 6278085.
↑ Williams M. Anxioselective anxiolytics. Journal of Medicinal Chemistry. 1983 May;26(5):619-28. PMID 6132997
↑ Williams M, Jarvis MF. Adenosine antagonists as potential therapeutic agents. Pharmacology Biochemistry and Behaviour. 1988 Feb;29(2):433-41. PMID 3283781
↑ Zezula J, Slany A, Sieghart W. Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. European Journal of Pharmacology. 1996 Apr 22;301(1-3):207-14. PMID 8773466
↑ Wang P, Myers JG, Wu P, Cheewatrakoolpong B, Egan RW, Billah MM. Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. Biochemical and Biophysical Research Communications. 1997 May 19;234(2):320-4. PMID 9177268

Template:Phosphodiesterase inhibitors Template:Anxiolytics

Template:WikiDoc Sources

[pmid6278085-1] Ticku MK, Davis WC (1982). "Molecular interactions of etazolate with benzodiazepine and picrotoxinin binding sites". J. Neurochem. 38 (4): 1180–2. PMID 6278085.

[2] Williams M. Anxioselective anxiolytics. Journal of Medicinal Chemistry. 1983 May;26(5):619-28. PMID 6132997

[3] Williams M, Jarvis MF. Adenosine antagonists as potential therapeutic agents. Pharmacology Biochemistry and Behaviour. 1988 Feb;29(2):433-41. PMID 3283781

[4] Zezula J, Slany A, Sieghart W. Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. European Journal of Pharmacology. 1996 Apr 22;301(1-3):207-14. PMID 8773466

[5] Wang P, Myers JG, Wu P, Cheewatrakoolpong B, Egan RW, Billah MM. Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. Biochemical and Biophysical Research Communications. 1997 May 19;234(2):320-4. PMID 9177268

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Etazolate

Overview

See also

References

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