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'''For patient information, click [[Esophageal stricture (patient information)|here]]'''
'''For patient information, click [[Esophageal stricture (patient information)|here]]'''


{{CMG}}; {{AE}}{{MA}} [mailto:malihash@bidmc.harvard.edu] 
{{CMG}}; {{AE}}{{MA}}  
 
==[[Esophageal stricture overview|Overview]]==
==[[Esophageal stricture overview|Overview]]==


==[[Esophageal stricture historical perspective|Historical Perspective]]==
==[[Esophageal stricture historical perspective|Historical Perspective]]==
First intervention for esophaegal stricture was done in the 17 century by whalebone. The first bougienage was performed in 1801. In 1868, esophagoscope was developed for the first time. In 1877, first surgical [[resection]] for esophaegal [[carcinoma]] was performed by Vincenz Czerny. First stent was introduced in 1990.


==[[Esophageal stricture classification|Classification]]==
==[[Esophageal stricture classification|Classification]]==
There is no established system for the classification of [[esophageal]] [[stricture]], but it may be classified into [[benign]] and [[malignant]] according to causes.


==[[Esophageal stricture pathophysiology|Pathophysiology]]==
==[[Esophageal stricture pathophysiology|Pathophysiology]]==
It is thought that [[esophageal]] [[stricture]] is the result of lower pressure of [[esophageal sphincter]] in [[gastroesophageal reflux disease]], esophageal motor disorder, [[inflammation]] and [[fibrosis]] in [[neoplasia]]. The most characteristic finding in [[gross pathology]] is thickening of the lower [[esophageal]] wall in [[gastroesophageal reflux disease]], pale [[mucosa]] in [[lymphocytic]] [[esophagitis]] and [[hemorrhagic]] [[congestion]] in [[caustic]] ingestion.
[[Microscopic]] [[histopathological]] characteristic findings of [[esophageal]] [[stricture]] is inntraepithelial [[lymphocytes]] and [[basal cell]] [[hyperplasia]] in [[gastroesophageal reflux disease]], [[Infiltration (medical)|infiltration]] T [[lymphocytes]] in [[squamous]] [[mucosa]] in [[lymphocytic]] [[esophagitis]] and [[eosinophilic]] [[necrosis]] in [[caustic]] ingestion


==[[Esophageal stricture causes|Causes]]==
==[[Esophageal stricture causes|Causes]]==
Common causes of [[esophageal]] [[stricture]] include [[gastroesophageal reflux disease]] and [[caustic]] ingestions.


==[[Esophageal stricture differential diagnosis|Differentiating Esophageal stricture from other Disorders]]==
==[[Esophageal stricture differential diagnosis|Differentiating Esophageal stricture from other Disorders]]==
Esophageal stricture must be differentiated from plummer-vinson syndrome, [[achalasia]] , [[diffuse esophageal spasm]], [[systemic sclerosis]], [[zenker's diverticulum]], [[Esophageal cancer|esophageal carcinoma]], [[stroke]], motor disorders, [[GERD]][[Esophageal web|, esophageal web]].


==[[Esophageal stricture epidemiology and demographics|Epidemiology and Demographics]]==
==[[Esophageal stricture epidemiology and demographics|Epidemiology and Demographics]]==
Most of [[esophageal]] [[strictures]] are related to [[gastroesophageal reflux disease]]. Overall incidence of [[esophageal stricture]] is approximately 11 per 100,000 individuals and the [[prevalence]] of [[esophageal]][[stricture]] is approximately 70-120 per 100,000 individuals in united states. The [[incidence]] of [[esophageal]] [[stricture]] increases with age. There is no racial predilection to [[esophageal]] [[stricture]]. The risk of [[esophageal]] [[stricture]] is higher in men under 60 yr but there is similar [[incidence]] in men and women after age 60.


==[[Esophageal stricture risk factors|Risk Factors]]==
==[[Esophageal stricture risk factors|Risk Factors]]==
The most potent [[risk factor]] in the development of [[esophageal]] [[stricture]] is frequent [[acid reflux]]. Other [[risk factor]]<nowiki/>s include [[Hiatus hernia|hiatal hernia]], [[obesity]], [[smoking]], [[esophageal dysmotility]], increased [[gastric]] acidity, and heavy [[alcohol]] use.
 


==[[Esophageal stricture natural history, complications and prognosis|Natural History, Complications, and Prognosis]]==
==[[Esophageal stricture natural history, complications and prognosis|Natural History, Complications, and Prognosis]]==
If left untreated, patients with [[esophageal]] [[stricture]] may progress to develop [[pulmonary aspiration]], [[weight loss]], and [[dehydration]]. Common [[complication]]<nowiki/>s of [[esophageal]] [[stricture]] include [[perforation]], [[bleeding]], [[pneumonia]], [[bacteremia]]. [[Prognosis]] is generally good but recurrence of symptoms after [[dilation]] are prevalent and usually recurrent [[dilation]] is necessary.
 


==Diagnosis==
==Diagnosis==
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* [[Esophageal cancer]]
* [[Esophageal cancer]]
* [[Esophagitis]]
* [[Esophagitis]]
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Latest revision as of 21:40, 29 July 2020

Esophageal stricture
Endoscopic image of a benign peptic stricture
ICD-9 530.3
DiseasesDB 31502
MedlinePlus 000207

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Esophageal stricture from other Disorders

Epidemiology and Demographics

Risk Factors

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Rays | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgical | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

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Case #1

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