Epithelioid sarcoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

The symptoms of epithelioid sarcoma usually develop in the second decade of life and start with symptoms such as mass. Epithelioid sarcoma has a tendency to lymph node metastasis. The most common sites of epithelioid metastasis include lungs, lymph nodes, and scalp. Common complications of epithelioid sarcoma include metastasis, nerve compression, and numbness. The prognosis of epithelioid sarcoma is good for females.

Natural History

The symptoms of epithelioid sarcoma usually develop in the second decade of life and start with symptoms such as mass. Epitheliod sarcoma has a tendency to lymph node metastasis. The most common sites of epithelioid metastasis include lungs, lymph nodes, and scalp.

Complications

  • Metastasis
  • Contractures
  • Nerve compression
  • Muscle weakness
  • Numbness

Prognosis

  • The prognosis of epithelioid sarcoma is good for females.
  • Five-year survival rate for patients with epithelioid sarcoma is approximately 50-70%
  • Ten-year survival rate for patients with epithelioid sarcoma is approximately 42-55%
  • Prognosis varies with:
  • Age of diagnosis- Earlier age of diagnosis is associated with better outcome
  • Gender
  • Site- Proximal lesions have worse prognosis
  • Microscopic pathology- Necrosis and vascular invasion have been associated with poor prognosis
  • Tumor size- Tumors of more than 2 cm size has been associated with poor prognosis[1]
  • Mitotic index

References

  1. Epithelioid sarcoma. Sarcomahelp (2016). http://sarcomahelp.org/epithelioid-sarcoma.html Accessed on February 8, 2016


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