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{{Eosinophilia}}
{{Eosinophilia}}
{{CMG}}; {{AOEIC}} {{LG}}
{{CMG}}; {{AOEIC}} {{LG}}, George Leef MD


== Overview ==
{{SK}} Eosinophil count raised (peripheral blood), hereditary eosinophilia
 
*Eosinphilia refers to a group of idiopathic, neoplastic, infectious and allergic illnesses
*Eosinphilia is associated with abnormally high number of eosinphil granulocytes in the serum and/or tissue
* Reference range: '''0-450 ul'''


== Differential Diagnosis of Causes of {{PAGENAME}} ==
==[[Eosinophilia overview|Overview]]==
===By Organ System===
{|height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Endomyocardial fibrosis]], [[Cholesterol embolism]], [[Loeffler  endocarditis ]],  [[Eosinophilic myocarditis]]
|-
|-bgcolor="LightSteelBlue"
| '''Chemical / poisoning'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| [[Erythema multiforme]], [[Atopic dermatitis]], [[Dermatitis herpetiformis]], [[fasciitis|Eosinophilic fasciitis]], [[folliculitis|Eosinophilic pustular folliculitis]], [[Pemphigus vulgaris]], [[Psoriasis]], [[Systemic lupus erythematosus]], [[Scabies|Sarcoptes scabiei]], [[Eczema ]], [[Exfoliative dermatitis  ]], [[Urticaria ]], [[Eosinophilic panniculitis    ]], [[Shulman’s syndrome ]], [[Stevens -  Johnson syndrome ]], [[Duhring disease ]], [[Histiositosis with cutaneous involvement ]]


|-
==[[Eosinophilia historical perspective|Historical Perspective]]==
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Sulphonamides]], [[Allopurinol]], [[Amitriptyline]], [[Capreomycin]], [[Caspofungin]], [[Chlorpropamide]], [[Clomipramine]], [[Daptomycin]], [[Desipramine]], [[Dothiepin]], [[Doxycycline]], [[Enfuvirtide]], [[Etravirine]], [[Gold salts]], [[Granulocyte-macrophage colony stimulating factor]], [[Hydralazine]], [[Imipramine]], [[Interleukin 2]], [[Micafungin]], [[Minocycline]], [[Nalidixic acid]], [[Nitrofurantoin]], [[Nortriptyline]], [[Olanzapine]], [[Oxytetracycline]], [[Pentostatin]], [[Procarbazine]], [[Smoking|Tobacco smoking]], [[Tryptophan]], [[Vancomycin]], [[Aldesleukin ]], [[Amikacin Sulfate  ]], [[Capastat Sulfate ]], [[Capreomycin Sulfate  ]], [[Cefotaxime Sodium  ]], [[Cefoxitin Sodium ]], [[Ceftazidime ]], [[Cefuroxime ]], [[LyphocinMaolate]]


|-
==[[Eosinophilia pathophysiology|Pathophysiology]]==
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| [[Adrenal cortex insufficiency]], [[Addisons disease ]], [[Adrenocortical insufficiency]]


|-
==[[Eosinophilia causes|Causes]]==
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| An allergic reaction to an environmental antigen
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Inflammatory Bowel Disease ]], [[Cirrhosis of liver ]], [[Chronic active hepatitis ]], [[Eosinophilic Gastroenteritis ]], [[Peritoneal dialysis ]]


|-
==[[Eosinophilia differential diagnosis|Differentiating Eosinophilia from other Diseases]]==
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| [[Autoimmune lymphoproliferative syndrome|Autoimmune lymphoproliferative syndrome type 1]], [[Autoimmune lymphoproliferative syndrome|Autoimmune lymphoproliferative syndrome type 2]], [[Familial eosinophilia]], [[Kostmann disease]], [[Omenn syndrome]], [[Wiskott-Aldrich syndrome]], [[TAR syndrome]], [[kostmann syndrome]], [[Chromosome 21 partial deletion ]]


|-
==[[Eosinophilia epidemiology and demographics|Epidemiology and Demographics]]==
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| [[Acute lymphoblastic leukemia]], [[Chronic myeloid leukaemia]], [[Hodgkin lymphoma]], [[Thrombocytopenia  with absent radii ]], [[Familial reticuloendotheliosis with  eosinophilia]]


|-
==[[Eosinophilia risk factors|Risk Factors]]==
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| [[Radiotherapy]]
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| [[Acanthocheilonemiasis]], [[Alveolar hydatid disease]], [[Ancylostoma caninum]], [[Ancylostoma duodenale]], [[Angiostrongyliasis]], [[Anisakiasis]], [[Ascariasis]], [[Capillaria]], [[Clonorchiasis]], [[Coccidioidomycosis]], [[Dicrocoelium dendriticum fluke]], [[Dracunculiasis]], [[Echinococcus granulosus]], [[Fasciola hepatica]], [[Gnathostomiasis]], [[Heterophyiasis]], [[Lepromatous leprosy]], [[Loa loa filariasis]], [[Lymphatic filariasis]], [[Mansonelliasis]], [[Metagonimiasis]], [[Mycobacterium tuberculosis]], [[Onchocerciasis]], [[Opisthorchiasis]], [[Paragonimiasis]], [[Schistosoma haematobium]], [[Schistosoma mansoni]], [[Strongyloidiasis]], [[Toxocariasis]], [[Trichinella spiralis]], [[Pneumocystis  jirovecii infection ]], [[Visceral larva migrans ]], [[Brucellosis ]], [[Cat-scratch fever ]], [[Chlamydial pneumonia of infancy ]], [[Infectious lymphocytosis ]], [[Infectious mononucleosis ]], [[Scarlet fever]], [[Amebiasis ]], [[Malaria ]]


|-
==[[Eosinophilia natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal / Ortho'''
|bgcolor="Beige"| [[Polyarteritis nodosa]], [[Polymyositis]], [[Rheumatoid disease]], [[Dressler's  syndrome ]], [[Eosinophilic fasciitis ]], [[Idiopathic eosinophilic synovitis ]], [[Progressive systemic sclerosis  (scleroderma) ]], [[SLE ]], [[Sjögren's syndrome ]], [[Sarcoidosis  ]], [[Eosinophilia – Myalgia syndrome ]], [[Dermatomyositis ]]


|-
==Diagnosis==
|-bgcolor="LightSteelBlue"
[[Eosinophilia history and symptoms|History and Symptoms]] | [[Eosinophilia physical examination|Physical Examination]] | [[Eosinophilia laboratory findings|Laboratory Findings]] | [[Eosinophilia CT|CT]] | [[Eosinophilia other diagnostic studies|Other Diagnostic Studies]]
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional / Metabolic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| [[Acute lymphoblastic leukemia]], [[Chronic myeloid leukaemia]], [[Hodgkin lymphoma]], [[Immunoblastic  lymphadenopathy ]], [[Sarcomas and carcinomas of ovary]], [[Carcinoma of pancreas ]], [[Carcinoma of lung ]], [[Carcinoma of colon]], [[Carcinoma of cervix ]], [[Acute eosinophilic leukemia  ]], [[Chronic eosinophilic leukemia ]], [[Brain tumors  ]]


|-
==Treatment==
|-bgcolor="LightSteelBlue"
[[Eosinophilia medical therapy|Medical Therapy]] | [[Eosinophilia surgery|Surgery]] | [[Eosinophilia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Eosinophilia future or investigational therapies|Future or Investigational Therapies]]
| '''Opthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose / Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| [[Simple pulmonary eosinophilia]], [[Visceral larva migrans]], [[Allergic bronchopulmonary aspergillosis]], [[Extrinsic allergic alveolitis]], [[Tropical pulmonary eosinophilia]], [[Churg-Strauss syndrome]], [[Bronchial asthma]], [[Allergic  Rhinitis]], [[Chronic eosinophilic pneumonia ]], [[Occupational lung diseases ]], [[Idiopathic eosinophilic chronic  pneumopathy ]], [[Magrassi- Leonardi syndrome ]]


|-
==Case Studies==
|-bgcolor="LightSteelBlue"
[[Eosinophilia case study one|Case #1]]
| '''Renal / Electrolyte'''
|bgcolor="Beige"| [[Interstitial nephritis]], [[Eosinophilic cystitis ]], [[Hemodialysis ]], [[CRF not on renal replacement therapy ]], [[Diffuse proliferative glomerular  nephritis ]], [[Thrombotic thrombocytopenic purpura ]], [[Renal cell carcinoma]]
 
|-
|-bgcolor="LightSteelBlue"
| '''Rheum / Immune / Allergy''' 
|bgcolor="Beige"| [[Eosinophilia-myalgia syndrome]],[[Hyper-IgE  syndrome ]], [[IgA deficiency ]], [[Wiskott-Aldrich syndrome  ]],[[Graft versus host immunologic reactions  ]],[[Milk protein allergy ]], [[Omenn syndrome ]], [[Severe congenital Neutropenia ]]
 
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| [[Angiolymphoid hyperplasia with eosinophilia]], [[cellulitis|Eosinophilic cellulitis]], [[Hypereosinophilic syndrome]], [[Kimura disease]], [[Familial  eosinophilia ]], [[Episodic angioedema with  eosinophilia  ]], [[Aggressive systemic mastocytosis ]]
|-
|}
 
===In alphabetical order <ref>Sailer, Christian, Wasner, Susanne.  Differential Diagnosis Pocket.  Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:127-128 ISBN 1591032016
</ref>===
 
*[[Acanthocheilonemiasis]]
 
*[[Acute lymphoblastic  leukemia ]]
 
*[[Acute eosinophilic leukemia ]]
 
*[[Chronic  eosinophilic leukemia ]]
 
*[[Addisons disease ]]
 
*[[Adrenocortical  insufficiency]]
 
*[[Aggressive systemic  mastocytosis ]]
 
*[[Aldesleukin ]]
 
*[[Allergic bronchopulmonary  aspergillosis ]]
 
*[[Allergic Rhinitis]]
 
*[[Allopurinol ]]
 
*[[Alveolar hydatid disease ]]
 
*[[Amebiasis ]]
 
*[[Amikacin Sulfate  ]]
 
*[[Amitriptyline ]]
 
*[[Ancylostoma caninum ]]
 
*[[Ancylostoma duodenale ]]
 
*[[Angiolymphoid hyperplasia  with eosinophilia ]]
 
*[[Angiostrongyliasis ]]
 
*[[Anisakiasis ]]
 
*[[Ascariasis ]]
 
*[[Atopic dermatitis ]]
 
*[[Autoimmune  lymphoproliferative syndrome type 1 ]]
 
*[[Autoimmune  lymphoproliferative syndrome type 2 ]]
 
*[[Brain Tumors  ]]
 
*[[Bronchial asthma ]]
 
*[[Brucellosis ]]
 
*[[Capastat Sulfate ]]
 
*[[Capillaria ]]
 
*[[Capreomycin ]]
 
*[[Caspofungin ]]
 
*[[Cat-scratch fever ]]
 
*[[Cefotaxime Sodium  ]]
 
*[[Cefoxitin Sodium ]]
 
*[[Ceftazidime ]]
 
*[[Cefuroxime ]]
 
*[[Chlamydial pneumonia of  infancy ]]
 
*[[Chlorpropamide ]]
 
*[[Cholesterol embolism  ]]
 
*[[Chromosome 21 partial  deletion    ]]
 
*[[Chronic active hepatitis ]]
 
*[[Chronic eosinophilic  pneumonia ]]
 
*[[Chronic myeloid leukaemia  ]]
 
*[[Churg-Strauss syndrome ]]
 
*[[Cirrhosis ]]
 
*[[Cirrhosis of liver ]]
 
*[[Clomipramine]]
 
*[[Clonorchiasis ]]
 
*[[Coccidioidomycosis ]]
 
*[[CRF not on renal  replacement therapy ]]
 
*[[Daptomycin ]]
 
*[[Dermatitis herpetiformis ]]
 
*[[Dermatomyositis ]]
 
*[[Desipramine ]]
 
*[[Dicrocoelium dendriticum  fluke ]]
 
*[[Diffuse proliferative  glomerular nephritis ]]
 
*[[Dothiepin ]]
 
*[[Doxycycline ]]
 
*[[Dracunculiasis ]]
 
*[[Dressler's syndrome ]]
 
*[[Duhring's disease ]]
 
*[[Echinococcus granulosus ]]
 
*[[Eczema ]]
 
*[[Endomyocardial fibrosis ]]
 
*[[Enfuvirtide ]]
 
*[[Eosinophilia – myalgia  syndrome ]]
 
*[[Eosinophilic cellulitis ]]
 
*[[Eosinophilic cystitis ]]
 
*[[Eosinophilic fasciitis ]]
 
*[[Eosinophilic  gastroenteritis ]]
 
*[[Eosinophilic myocarditis]]
 
*[[Eosinophilic  panniculitis  ]]
 
*[[Eosinophilic pustular  folliculitis ]]
 
*[[Episodic angioedema with  eosinophilia ]]
 
*[[Erythema multiforme ]]
 
*[[Etravirine ]]
 
*[[Exfoliative dermatitis  ]]
 
*[[Extrinsic allergic  alveolitis ]]
 
*[[Familial eosinophilia ]]
 
*[[Familial eosinophilia]]
 
*[[Familial  reticuloendotheliosis with eosinophilia]]
 
*[[Fasciola hepatica ]]
 
*[[Gnathostomiasis ]]
 
*[[Gold salts ]]
 
*[[Graft versus host  immunologic reactions ]]
 
*[[Granulocyte-macrophage  colony stimulating factor ]]
 
*[[Hemodialysis ]]
 
*[[Heterophyiasis ]]
 
*[[Histiositosis with  Cutaneous involvement ]]
 
*[[Hodgkin lymphoma ]]
 
*[[Hydralazine ]]
 
*[[Hypereosinophilic  syndrome  ]]
 
*[[Hyper-IgE syndrome ]]
 
*[[Idiopathic eosinophilic  chronic pneumopathy ]]
 
*[[Idiopathic eosinophilic  synovitis ]]
 
*[[IgA deficiency ]]
 
*[[Imipramine ]]
 
*[[Immunoblastic  lymphadenopathy ]]
 
*[[Infectious lymphocytosis ]]
 
*[[Infectious mononucleosis ]]
 
*[[Inflammatory Bowel Disease  ]]
 
*[[Interleukin 2 ]]
 
*[[Interstitial nephritis ]]
 
*[[Kimura disease ]]
 
*[[Kostmann syndrome]]
 
*[[Lepromatous leprosy ]]
 
*[[Loa loa filariasis ]]
 
*[[Loeffler endocarditis ]]
 
*[[L-Tryptophan use ]]
 
*[[Lymphatic filariasis ]]
 
*[[Lyphocin maolate ]]
 
*[[Magrassi- Leonardi syndrome  ]]
 
*[[Malaria ]]
 
*[[Mansonelliasis ]]
 
*[[Metagonimiasis ]]
 
*[[Micafungin ]]
 
*[[Milk protein allergy ]]
 
*[[Minocycline ]]
 
*[[Mycobacterium tuberculosis  ]]
 
*[[Nalidixic acid ]]
 
*[[Nitrofurantoin ]]
 
*[[Nortriptyline ]]
 
*[[Occupational lung diseases ]]   
 
*[[Olanzapine ]]
 
*[[Omenn syndrome ]]
 
*[[Onchocerciasis ]]
 
*[[Opisthorchiasis ]]
 
*[[Oxytetracycline]]
 
*[[Paragonimiasis ]]
 
*[[Pemphigus vulgaris ]]
 
*[[Pentostatin ]]
 
*[[Peritoneal dialysis ]]
 
*[[Pneumocystis jirovecii  infection ]]
 
*[[Polyarteritis nodosa ]]
 
*[[Polymyositis ]]
 
*[[Procarbazine ]]
 
*[[Progressive systemic  sclerosis (scleroderma) ]]
 
*[[Psoriasis ]]
 
*[[RA ]]
 
*[[Radiation therapy ]]
 
*[[Radiotherapy]]
 
*[[Renal cell carcinoma]]
 
*[[Sarcoidosis ]]
 
*[[Sarcomas and carcinomas of  Ovary/ Cervix Pancreas Lung, colon ]]
 
*[[Sarcoptes scabiei  ]]
 
*[[Scarlet fever ]]
 
*[[Schistosoma haematobium ]]
 
*[[Schistosoma mansoni ]]
 
*[[Severe congenital  Neutropenia ]]
 
*[[Shulman’s syndrome ]]
 
*[[Simple pulmonary  eosinophilia ]]
 
*[[Sjögren's syndrome ]]
 
*[[SLE ]]
 
*[[Stevens -  Johnson syndrome ]]
 
*[[Strongyloidiasis ]]
 
*[[Sulphonamides ]]
 
*[[Systemic lupus  erythematosus ]]
 
*[[TAR syndrome]]
 
*[[Thrombocytopenia with  absent radii]]
 
*[[Thrombotic thrombocytopenic  purpura ]]
 
*[[Tobacco smoking ]]
 
*[[Toxocariasis ]]
 
*[[Trichinella spiralis ]]
 
*[[Tropical pulmonary  eosinophilia ]]
 
*[[Tryptophan ]]
 
*[[Urticaria ]]
 
*[[Vancomycin Hydrochloride ]]
 
*[[Vancomycin]]
 
*[[Visceral larva migrans ]]
 
*[[Wiskott-Aldrich  syndrome  ]]


==Related Chapters==
==Related Chapters==
Line 494: Line 48:
*[[Monocytosis]]
*[[Monocytosis]]
*[[Lymphocytosis]]
*[[Lymphocytosis]]
== References ==
{{Reflist|2}}


[[Category:Laboratory Test]]
[[Category:Laboratory Test]]
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Infectious disease]]
 
[[Category:Blood tests]]
[[Category:Blood tests]]


Latest revision as of 17:41, 18 September 2017

Eosinophilia
DiseasesDB 4328

Eosinophilia Microchapters

Home

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Eosinophilia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X-Ray

CT

MRI

Other imaging findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Eosinophilia On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Eosinophilia

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Eosinophilia

CDC on Eosinophilia

Eosinophilia in the news

Blogs on Eosinophilia

Directions to Hospitals Treating Eosinophilia

Risk calculators and risk factors for Eosinophilia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2], George Leef MD

Synonyms and keywords: Eosinophil count raised (peripheral blood), hereditary eosinophilia

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Eosinophilia from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | CT | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Related Chapters


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